Ibuprofen and Blood Pressure

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Fifty Hertz - 01 Jun 2004 10:07 GMT

In January, I was diagnosed with osteoarthritis of the hands, and put on the
maximum dose of Ibuprofen.

I monitored my blood pressure every week, starting in May, and found the
readings to be higher than my previous pattern: mid 140's/mid 90's, as
compared to low 120's/low 70's.

Very recently, I switched to AC&C for a back problem, and my blood pressure
dropped right back to the old values. I am going to switch to ASA.

Does Ibuprofen provoke higher blood pressure? There is no such warning on
the packaging.

Thanks,

C.

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Gregory Poon - 02 Jun 2004 04:38 GMT

> Does Ibuprofen provoke higher blood pressure? There is no such warning on
> the packaging.

Long-term use of any nonsteroidal anti-inflammatories can lead to
hypertension via an effect on the kidney's ability to control blood
pressure. There have been cases where people were not careful with this and
ended up with strokes and other cardiovascular incidents. The coxibs (e.g.,
Celebrex, Vioxx) are in principle safer in this respect but all
nonsteroidals should be considered suspect if the dose is high enough (and
used for long enough). The AC&C might have relieved this by reducing your
exposure to the ASA (with the added codeine).

Signature

Gregory M. K. Poon, Ph.D., R.Ph., B.Sc.Phm.
Departments of Pharmaceutical Sciences & Chemical Engineering and Applied
Chemistry
University of Toronto

> In January, I was diagnosed with osteoarthritis of the hands, and put on the
> maximum dose of Ibuprofen.
[quoted text clipped - 9 lines]
>
> C.

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Sam - 02 Jun 2004 04:40 GMT

"The popular pain relievers ibuprofen and acetaminophen, contained in scores
of over-the-counter remedies, may increase the risk of high blood pressure,
a study in women suggests."

http://www.smh.com.au/articles/2002/10/28/1035683359244.html

> In January, I was diagnosed with osteoarthritis of the hands, and put on the
> maximum dose of Ibuprofen.
[quoted text clipped - 12 lines]
>
> C.

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Fifty Hertz - 03 Jun 2004 01:23 GMT

> "The popular pain relievers ibuprofen and acetaminophen, contained in scores
> of over-the-counter remedies, may increase the risk of high blood pressure,
> a study in women suggests."
> http://www.smh.com.au/articles/2002/10/28/1035683359244.html

In my case, I find this to be an eerie parallel. My Pharmacist had no
information in this case at all.

All I can expect at this point is that I am a 'patient contributor' to the
study's findings.

C.

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