intravenous hydrogen peroxide

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Paul Trusten - 08 Aug 2003 12:29 GMT

(Posted on the sci.med.pharmacy newsgroup).

At my workout this morning, my trainer happened to mention that he had just
gotten a treatment of IV hydrogen peroxide to help him heal his leg
abrasion. My jaw dropped; I had never heard of such therapy, and surmised
that it is part of alternative medicine. A peek at the web this morning
confirmed this for me. What I was looking for, out of curiosity, was the
typical formulation of such an IV product. Would it be prepared from topical
H2O2 using a Millipore filter? Does anyone on this newsgroup have any
experience either receiving this therapy or, among pharmacists, dispensing
it? Is it commercially available as a sterile product? Is it used at all at
one or more university health science centers? I'm frustrated by the web
info because it seems to talk about it in terms of alternative medicine
"speak" without getting down to specific formulations.

Signature

Paul Trusten, R.Ph.
3609 Caldera Boulevard, Apartment 122
Midland TX 79707-2872 USA
432-694-6208
ptrusten@cox.net

American measurement is hard by the yard,
but it will be neater by the meter.

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HankG - 08 Aug 2003 14:16 GMT

> (Posted on the sci.med.pharmacy newsgroup).
>
[quoted text clipped - 5 lines]
> typical formulation of such an IV product. Would it be prepared from topical
> H2O2 using a Millipore filter?

<snip>

As I recall, H202 was made with a small amount of acetanilid (somewhat like
phenacetin) as a stabilizer. Acetanilid was contained in Bromo-Seltzer, was
later banned. Although the amount in H202 is small, it could be a problem
if given I.V.

Would you have any idea as to the dose/volume of solution administered as a
treatment? If a small
amount (%) of peroxide, most likely given as an additive, and probably
prepared by 'sterile' filtration, since a stabilizer-free solution of
peroxide might not handle the stress of terminal sterilization. This might
rule out that the peroxide was prepared as a large volume parenteral, which
are terminally sterilized.

HankG

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Paul Trusten - 08 Aug 2003 19:13 GMT

This is the very thing I was curious about, and hopeful that someone on this
NG could tell us. My friend said that it was a small volume (sounds like 100
ml) given over 90 minutes. I was just curious as to the amount or percent of
H2O2, the diluent, and the method of manufacture or acquisition. It was
administered under a physician's supervision, but at a location at which
other alternative methods are used, e.g. UV irradiation and
re-administration of an autologous blood donation (!).

Signature

Paul Trusten, R.Ph.
3609 Caldera Boulevard, Apartment 122
Midland TX 79707-2872 USA
432-694-6208
ptrusten@cox.net

American measurement is hard by the yard,
but it will be neater by the meter.

>
> > (Posted on the sci.med.pharmacy newsgroup).
[quoted text clipped - 25 lines]
>
> HankG

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wc - 09 Aug 2003 05:05 GMT

> Is it used at all at
> one or more university health science centers?

Yes and no. I have seen a plastic surgeon clean a wound he was about to
debride, or perform surgery on the area . . . but not intervenously,
perish the thought! I do believe I would have called for the chief of
surgery to STOP it, or better yet, the Head Nurse of Surgery from my
humble seat and status at the anesthesia machine.

Will, crna

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