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Medical Forum / General / Pharmacy / April 2004

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Question on Blood Levels: Pamelor, Midrin

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MaryJoKopechne - 08 Apr 2004 21:52 GMT
For almost 2 years my husband has been taking 2 drugs for a head injury and
headaches:

Nortriptyline (aka: Pamelor)     50 mg    1 at night
Migrazone   (aka: Midrin)                      3 pills a day

Is there a way of testing to see what his blood level is of these med's? What
should that blood level be? If he stops these meds and goes to another
painreliever, how long before he no longer has a blood level of these 2
medications?

Thanks, for your help!
Gregory Poon - 09 Apr 2004 00:00 GMT
Hospital people correct me if I'm wrong, but I don't think people routinely
take levels of these meds.  Tricyclics like nortriptyline might be screened
for in emergent situations (e.g., overdose).  I think the question is,
whether it's necessary in cases like yours to measure the levels, since
one's usually really interested (with these drugs) in the clinical response
(reduction of severity of pain, frequency, side effects, etc.) and not the
levels per se.  As for washout periods, it depends on what drug he's being
switched to, but neither of the drugs mention sound like major concerns to
me.

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Gregory M. K. Poon, Ph.D., R.Ph., B.Sc.Phm.
Departments of Pharmaceutical Sciences and Chemical Engineering
University of Toronto
Toronto, Ontario

> For almost 2 years my husband has been taking 2 drugs for a head injury and
> headaches:
[quoted text clipped - 8 lines]
>
> Thanks, for your help!
MaryJoKopechne - 09 Apr 2004 22:08 GMT
Hospital people correct me if I'm wrong, but I don't think people routinely
take levels of these meds.  Tricyclics like nortriptyline might be screened
for in emergent situations (e.g., overdose).  I think the question is,
whether it's necessary in cases like yours to measure the levels, since
one's usually really interested (with these drugs) in the clinical response
(reduction of severity of pain, frequency, side effects, etc.) and not the
levels per se.  As for washout periods, it depends on what drug he's being
switched to, but neither of the drugs mention sound like major concerns to
me.

Signature

Gregory M. K. Poon, Ph.D., R.Ph., B.Sc.Phm.>>

Thanks for your considered opinion. We're debating what med he may want to
switch to.

 
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