CIALIS

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BIGAL052758 - 08 Mar 2004 20:45 GMT

I took cialis for the first time last week and have been experiencing seizures
since i took the first tablet. I experienced the first seizure about 30 hours
after taking and am wondering if this is a common side effect. I have not had
a seizure for years before this. I am no longer taking the drug. please write
me if you know anything about it. email address is huffmanskatecity@yahoo.com

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rastapasta - 08 Mar 2004 21:30 GMT

> I took cialis for the first time last week and have been experiencing seizures
> since i took the first tablet. I experienced the first seizure about 30 hours
> after taking and am wondering if this is a common side effect. I have not had
> a seizure for years before this. I am no longer taking the drug. please write
> me if you know anything about it. email address is huffmanskatecity@yahoo.com

Just a student here---not an expert, but I'll do some Googling here in a
bit, but is it a benzo (benzodiazepine), or what category drug is it?

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rastapasta - 08 Mar 2004 21:41 GMT

> > I took cialis for the first time last week and have been experiencing
> seizures
[quoted text clipped - 9 lines]
> Just a student here---not an expert, but I'll do some Googling here in a
> bit, but is it a benzo (benzodiazepine), or what category drug is it?

Well shoot. It looks like an ED treatment drug, but I also saw a link saying
it's a benzo, & it's another trade name for clonazepam, or Klonipin. Do you
have a Rx for it? Benzos are notorious for giving seizures, so I hear. I had
some myself while taking 2mg alprozolams. I'm sure someone else may jump in
on this one w/ some more info.

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Martin Maus - 09 Mar 2004 16:04 GMT

Hello,

sorry becouse of my bad english, I hope my explanation is understandable.

Cialis is not (if its the same as in Germany) a Benzodiazepine it is a
phosphodiesterase inhibitor and causes the venoles in the penis to
constrict. This causes an improved erection to people with erectyle
dysfunction.
Hence the excipiebt taldalafil in Cialis is a vasoconstriktor it is a
common side effect that your "blood pressure" may raise. If you are
vulnerable to seizures the higher pressure in your head may cause the
seizures.
It would be good if you tell this side effect to your medical doktor
who did the prescription.

I hope this answer helps you on.

Greetings Martin

>>Just a student here---not an expert, but I'll do some Googling here in a
>>bit, but is it a benzo (benzodiazepine), or what category drug is it?
[quoted text clipped - 4 lines]
> some myself while taking 2mg alprozolams. I'm sure someone else may jump in
> on this one w/ some more info.

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Me - 09 Mar 2004 20:28 GMT

> Hello,
>
[quoted text clipped - 13 lines]
>
> I hope this answer helps you on.

I agree that Cialis is not a benzodiazepine, but beg to differ on the
mechanism of action...

Cialis (tadalafil) is a vasodilator via PDE5 inhibition. It allows
increased flow into the penis, rather than limiting the flow out.

Rumor has it that the class (PDE5 inhibitors: Viagra, Levitra, Cialis) was
initially developed for use as antihypertensives.

Hypotension (LOW blood pressure), not hypertension, is likely the more
common side effect, especially when taken with nitrates (the combination
is contraindicated).

Having said that, hypertension is listed as a potential adverse reaction,
which I suppose is likely due to a rebound effect.

(Or maybe we're both right, and it simply works through different
mechanisms depending upon which side of the Atlantic you are on?)

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Jonathan Smith - 09 Mar 2004 23:37 GMT

> Hello,
>
> sorry becouse of my bad english, I hope my explanation is understandable.

It is inaccurate.

If you want prescribing information, I recommend

http://www.cialis.com/prescribe/index.jsp?location=prescribing

> Cialis is not (if its the same as in Germany) a Benzodiazepine

correct

> it is a
> phosphodiesterase inhibitor

a selective PDE5

> and causes the venoles in the penis to
> constrict.

wrong.

> This causes an improved erection to people with erectyle
> dysfunction.

Not likely. The mechanism of action is on arteriole dilatation and
relaxation of the corpus cavernosal smooth muscle through nitric
oxide release resulting in increased cGMP. In short - it lets the
blood go where it needs to go and in sufficient quantity.

> Hence the excipiebt taldalafil in Cialis is a vasoconstriktor it is a
> common side effect that your "blood pressure" may raise.

Wrong again. In fact, hypotension is likely and is a significant
potential problem in men taking nitrates for heart disease.

> If you are
> vulnerable to seizures the higher pressure in your head may cause the
> seizures.

wrong again.

> It would be good if you tell this side effect to your medical doktor
> who did the prescription.

No kidding.

Seizure disorder is not a recognized side effect of Cialis use. It has
not been documented in the medical literature, it is not listed in the
product insert.

> I hope this answer helps you on.

Now, perhaps.

js

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Martin Maus - 10 Mar 2004 08:26 GMT

Hello,

I'm sorry about my inaccurate explanation.

You are right, thank you for correction. The mechanism is the dilatation
and not the constriction of smooth muscle cells.

But I dont agree with you, that if there are no reported seizure
disorders in combination with the use of Cialis, that ther is in no way
a connection.

Cialis has as common reported side effects headache and nausea, which
are both coused within the nervous system. Also the described rebounce
effect of the hypotension (as you assumed I meant) could be the connection.

Side effects and are (on this side of the atlantic) also collected in
the as we call it Phase 4 of the registration progress of new medicines.
This is the period when the medicine is registered an sold, but not yet
improoved outside clinical trials. And many side effects did come
obvious whithin this period. ( Even a part of those side effects of
viagra like seeing the world in blue light. )

>>Hello,
>>
[quoted text clipped - 54 lines]
>
> js

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Jonathan Smith - 11 Mar 2004 15:27 GMT

> Hello,
>
> I'm sorry about my inaccurate explanation.

but you persist in doing it again - wieso?

> You are right, thank you for correction. The mechanism is the dilatation
> and not the constriction of smooth muscle cells.

The mechanism is PDE5 inhibition. The process includes increased
blood flow and relaxation of smooth muscle mediated through cGMP.
PDE5 enzyme inhibition slows the cGMP breakdown. So geht es.

> But I dont agree with you, that if there are no reported seizure
> disorders in combination with the use of Cialis, that ther is in no way
> a connection.

Das habe Ich aber nicht gesagt.

> Cialis has as common reported side effects headache and nausea, which
> are both coused within the nervous system. Also the described rebounce
> effect of the hypotension (as you assumed I meant) could be the connection.

Not necessarily - but if you want to argue b/b crossing, I won't
argue.

> Side effects and are (on this side of the atlantic) also collected in
> the as we call it Phase 4 of the registration progress of new medicines.
> This is the period when the medicine is registered an sold, but not yet
> improoved outside clinical trials. And many side effects did come
> obvious whithin this period. ( Even a part of those side effects of
> viagra like seeing the world in blue light. )

The above doesn't even warrant a reply other than to say - das is
saublod.

And visual effects are not CNS mediated, in case you were wondering.

js

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Martin Maus - 15 Mar 2004 11:58 GMT

Dear Mr. Smith,

Is it possible that you changed your e-mail adress?

Please contact me.

M.Maus

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Ron Peterson - 09 Mar 2004 20:28 GMT

I found the following comment in rxlist.com:
CIALIS(tm) (tadalafil), an oral treatment for erectile dysfunction, is
a selective inhibitor of cyclic guanosine monophosphate
(cGMP)-specific phosphodiesterase type 5 (PDE5). Tadalafil has the
empirical formula C22H19N3O4 representing a molecular weight of
389.41.

The chemical designation is
pyrazino[1¢,2¢:1,6]pyrido[3,4-b]indole-1,4-dione,
6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-,
(6R,12aR)-. It is a crystalline solid that is practically insoluble in
water and very slightly soluble in ethanol. CIALIS is available as
film-coated, almond-shaped tablets for oral administration. Each
tablet contains 5, 10, or 20 mg of tadalafil and the following
inactive ingredients: croscarmellose sodium, hydroxypropyl cellulose,
hypromellose, iron oxide, lactose monohydrate, magnesium stearate,
microcrystalline cellulose, sodium lauryl sulfate, talc, titanium
dioxide, and triacetin.

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Ron

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