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Medical Forum / General / Pharmacy / March 2004Tetracycline and DMSO
I suffer from mild(ish) acne rosacea and have been prescribed a mixture of tetracyclines under the name of Deteclo. After a 6 week course the rosacea disappears to gradually reappear after about the same length of time. The implication is that if I want to be free of it I have to spend half my life on antibiotics, which doesn't seem a good idea. Anyway, why dose the whole body when only a small patch of skin needs the antibiotic? (BTW, tried metrogel and it only sems to make thinsg worse). So I have just started to use a couple of Deteclo tablets crushed and dissolved in 50% DMSO/Water soln at around 3% strength in order to deliver the antibiotic striaght through the skin. Previously I have tested DMSO soln on the skin to see what effects it had. Briefly, it pretty much eliminated the swelling and inflamation associated with the condition, but did nothing for the underlying condition or colouration. It's too soon to report any effects from the latest effort, but I would appreciate any comments on this combination eg synergies if they exist, whether this has been tried before etc  SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org If you can stand the bad breath and the carrier method works, you don't expect the 'new' treatment to have a long-term effect, do you? Hopefully you don't suffer the same fate at the Toxic Lady. ;-) >I suffer from mild(ish) acne rosacea and have been prescribed a mixture of >tetracyclines under the name of Deteclo. [quoted text clipped - 17 lines] >appreciate any comments on this combination eg synergies if they exist, >whether this has been tried before etc > >I suffer from mild(ish) acne rosacea and have been prescribed a mixture of > >tetracyclines under the name of Deteclo. [quoted text clipped - 17 lines] > >appreciate any comments on this combination eg synergies if they exist, > >whether this has been tried before etc > If you can stand the bad breath and the carrier method works, you > don't expect the 'new' treatment to have a long-term effect, do you? > Hopefully you don't suffer the same fate at the Toxic Lady. ;-) The bad breath is not a problem given the very small amounts of DMSO being used. 30ml lasts for about 2 weeks, with the average application being around 1ml As for long term, anything is better than dosing my whole body on a perpetual basis. The wholebody dose from this method is probably <2% than swallowing tablets. Only one problem so far, and it is that the tablets are yellow inside and the soln appears to be staining my face. Not forever I hope... Also got around to trying DMSO 70% approx on muscle/tendon injury - it's a miracle doctor! Really works well. SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org >The bad breath is not a problem given the very small amounts of DMSO being >used. [quoted text clipped - 6 lines] >the soln appears to be staining my face. >Not forever I hope... Yikes. I was thinking that you're taking the pure drug. So you realize that not only is the tetracycline but also binders/excipients passing through your skin. >Also got around to trying DMSO 70% approx on muscle/tendon injury - it's a >miracle doctor! I use a 90% gel for acute serious muslce injuries. You're in good company with veterinarians and UK neurosurgeons. I'd still try to stay away from the non-medicinal ingredients in the tablets. >Really works well. > >The bad breath is not a problem given the very small amounts of DMSO being > >used. [quoted text clipped - 10 lines] > realize that not only is the tetracycline but also binders/excipients > passing through your skin. Not a problem apparently, since there appears to be a major insoluble component which I assume is the bulk of the above.. Besides, no reaction on a bit of skin I tried earlier (a scrap I didn't mind losing). > >Also got around to trying DMSO 70% approx on muscle/tendon injury - it's a > >miracle doctor! > > I use a 90% gel for acute serious muslce injuries. You're in good Don't you find that it stings rather a lot at that concentration? I couldn't tolerate anything >60% on my face. > company with veterinarians and UK neurosurgeons. I'd still try to > stay away from the non-medicinal ingredients in the tablets. Perhaps, but the ingredients are self evidently non toxic at least orally. > >Really works well. SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org >> I use a 90% gel for acute serious muslce injuries. You're in good > >Don't you find that it stings rather a lot at that concentration? >I couldn't tolerate anything >60% on my face. It is medical grade so maybe that plays a role; however, I seem to recall a little itching on occasion. Keep us updated! Darryl. Have you considered using some (commercial) antibiotic preparation for external use? (In Spain Wyeth Farma markets one named LEDER PAX (r), moisten towelettes with erythromycin) Is the DMSO you're using pharmaceutical grade? > I suffer from mild(ish) acne rosacea and have been prescribed a mixture of > tetracyclines under the name of Deteclo. [quoted text clipped - 17 lines] > appreciate any comments on this combination eg synergies if they exist, > whether this has been tried before etc > Have you considered using some (commercial) antibiotic preparation for > external use? (In Spain Wyeth Farma markets one named LEDER PAX (r), moisten > towelettes with erythromycin) Did not know such existed. I have used metrogel but that made things worse. The nice thing with DMSO is that it actually gets the active ingredients *through* the skin in significant quantities. For example, why does the whole body have to be dosed with something as nasty as Accutane rather than using a DMSO mix at 1% of normal dose? > Is the DMSO you're using pharmaceutical grade? Not in the sense you mean. It's certified for use in the production of pharmaceuticals and is 99.97% according to the data sheet. BTW, it's day 3 of the homemade treatment and already there is quite a noticeable improvement. A comparable stage with oral tetracyclines would (IIRC) require about 2 weeks, so I'm pretty optimistic at present. SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org |
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