Dosage and Race

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Fuli Chang - 04 Mar 2004 00:01 GMT

I've heard that due to various reasons, dosage proper for white and
black people can be too much for Asians such as Chinese. I have
following questions:

1. Is the above statement right?

2. If yes, what are the reasons?

3. Where can I find literature on this issue?

4. If not, is there any research? Where can I find it?

Thanks.

Fuli Chang

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Darryl - 04 Mar 2004 02:38 GMT

>I've heard that due to various reasons, dosage proper for white and
>black people can be too much for Asians such as Chinese. I have
>following questions:
>
>1. Is the above statement right?

Not absolutely. Go to google and enter "alcohol dehydrogenase asian"
for an example.

>2. If yes, what are the reasons?
>
>3. Where can I find literature on this issue?
>
>4. If not, is there any research? Where can I find it?

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BilZ0r - 04 Mar 2004 04:04 GMT

> I've heard that due to various reasons, dosage proper for white and
> black people can be too much for Asians such as Chinese. I have
> following questions:
>
> 1. Is the above statement right?

Its is correct. Although it's phrased really badly.

> 2. If yes, what are the reasons?

Just as people can have different genes that code for different eye
colors, or hieght or anything physical, people can have different genes
that code of enzymes that degrade drugs.

> 3. Where can I find literature on this issue?

I don't know any good books of the top of my head. The issue is called
"pharmacogenomics"

> 4. If not, is there any research? Where can I find it?

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed

The enzyme that springs into mind is one called CYP2D6, it is responsible
for the metabolism of many drugs, and varies extremely between people.

The point you need to be awear of, is that just because someone is of
asian decent dosn't mean that have the poor metabolizing version of the
CYP2D6 gene, or just because someone is caucasian, dosn't mean they have
the extensive metabolizing version of the gene... it just alters the
probability of having those genes.

In the future, it may be possible to test someones genetics to see what
enzymes they have, but right now it isn't possible.

> Thanks.
>
> Fuli Chang

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PsychopharmINFO - 22 Mar 2004 00:46 GMT

...

> In the future, it may be possible to test someones genetics to see what
> enzymes they have, but right now it isn't possible.

Actually, it is possible now. Companies like Signature Genetics and a
few others will do this with a cheek swab or blood test. Some require
that your physician order it and interpret it for you (this is
preferred, as it is not such a ::black and white:: issue).

Steve Daviss MD
www.psychopharminfo.com

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BilZ0r - 22 Mar 2004 04:01 GMT

I ment as a prerequisite to prescription.

>> In the future, it may be possible to test someones genetics to see
>> what enzymes they have, but right now it isn't possible.
[quoted text clipped - 6 lines]
> Steve Daviss MD
> www.psychopharminfo.com

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