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Medical Forum / General / Pharmacy / March 2004question about low-molecular-weight heparins
I'm feeling more and more like a tired dumb pharmacist. I was asked today "why lovenox?" "are low molecular weight heparins better than regular weight heparins?" "I'm pregnant and they put me on this, do you know why?". Sigh. I was so tired I couldn't think straight and told her I would call her tomorrow. ummm. What should I tell her? a helpful site here, found by typing on google: heparins molecular weight http://www.4um.com/tutorial/currents/lmwh.htm good luck ref > I'm feeling more and more like a tired dumb pharmacist. > I was asked today "why lovenox?" "are low molecular weight heparins [quoted text clipped - 6 lines] > > ummm. What should I tell her? Trust a pharmacist... lol... jks Don't ask me why, but I'm under the impression that- LMW Heparin probably causes less osteoporosis and thrombocytopenia than UF Heparin Also, LMWH isn't needed to be monitored as carfully as far as plasma concs go. and of course, they can't have warfarin because it crosses the placenta. > I'm feeling more and more like a tired dumb pharmacist. > I was asked today "why lovenox?" "are low molecular weight heparins [quoted text clipped - 28 lines] > > ------=_NextPart_000_00F1_01C40170.002F95E0-- I'm feeling more and more like a tired dumb pharmacist. I was asked today "why lovenox?" "are low molecular weight heparins better than regular weight heparins?" "I'm pregnant and they put me on this, do you know why?". for one LMWH are used in the outpatient setting because they have longer T1/2 and don't require continuous IV infusion and hospital admission, does she want to stay in the hospital? Sigh. I was so tired I couldn't think straight and told her I would call her tomorrow. ummm. What should I tell her? gotcha. Thanks. "skippercats" <none@nowhere.com> wrote in message news:4046a43c_3@127.0.0.1... I'm feeling more and more like a tired dumb pharmacist. I was asked today "why lovenox?" "are low molecular weight heparins better than regular weight heparins?" "I'm pregnant and they put me on this, do you know why?". >> for one LMWH are used in the outpatient setting because they have longer T1/2 and don't require continuous IV infusion and hospital admission, does she want to stay in the hospital? Sigh. I was so tired I couldn't think straight and told her I would call her tomorrow. ummm. What should I tell her? The low molecular weight heparins have several distinct adavatages. 1st, they do not require regular monitoring of INR, PTT, or aPTT if dosed per kg. Second, they can be administered OD deep s.c., or BID, depending on the indication. There is some evidence that the LMWH may be somewhat better in prevention or treatment of DVT, PE, and in the treatment of ACS. The fact that they do not need regular monitoring of aPTT or INR makes it easier to use in an outpatient setting. I don't think any of the heparins would be transferred in mothers-milk, as they are still significantly large structures, so that seems appropriate. LMWH - the low weight dose not refer to the weight of the vial or anything, just that they have taken heparin and seperated it into fractions, keeping the most active fractions and discarding the rest. This may in the end help to decrease the incidence of bleeding and other side effects. Outpatient administration of heparin requires regular monitoring of aPTT values and constant dosage adjustments. while the LMWH can be dosed without these tests. I'm feeling more and more like a tired dumb pharmacist. I was asked today "why lovenox?" "are low molecular weight heparins better than regular weight heparins?" "I'm pregnant and they put me on this, do you know why?". Sigh. I was so tired I couldn't think straight and told her I would call her tomorrow. ummm. What should I tell her? thanks The low molecular weight heparins have several distinct adavatages. 1st, they do not require regular monitoring of INR, PTT, or aPTT if dosed per kg. Second, they can be administered OD deep s.c., or BID, depending on the indication. There is some evidence that the LMWH may be somewhat better in prevention or treatment of DVT, PE, and in the treatment of ACS. The fact that they do not need regular monitoring of aPTT or INR makes it easier to use in an outpatient setting. I don't think any of the heparins would be transferred in mothers-milk, as they are still significantly large structures, so that seems appropriate. LMWH - the low weight dose not refer to the weight of the vial or anything, just that they have taken heparin and seperated it into fractions, keeping the most active fractions and discarding the rest. This may in the end help to decrease the incidence of bleeding and other side effects. Outpatient administration of heparin requires regular monitoring of aPTT values and constant dosage adjustments. while the LMWH can be dosed without these tests. "skippercats" <none@nowhere.com> wrote in message news:4046a43c_3@127.0.0.1... I'm feeling more and more like a tired dumb pharmacist. I was asked today "why lovenox?" "are low molecular weight heparins better than regular weight heparins?" "I'm pregnant and they put me on this, do you know why?". Sigh. I was so tired I couldn't think straight and told her I would call her tomorrow. ummm. What should I tell her? |
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