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Medical Forum / General / Pharmacy / April 2004DMSO
Why is this not widely used as a drug delivery system, esp for things like skin?  SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org >Why is this not widely used as a drug delivery system, esp for things like >skin? I'd guess bad breath, concerns over toxicity, and reactions between the drug and carrier. Doing a lot of guess work this morning ;-) Darryl. > >Why is this not widely used as a drug delivery system, esp for things like > >skin? > > I'd guess bad breath, concerns over toxicity, and reactions between > the drug and carrier. Doing a lot of guess work this morning ;-) I'd say that there is very little reaction since DMSO is a solvent widely used in the preparation of pharmaceuticals (but is generally not itself a feedstock). Bad breath is really only a problem if you bath in the stuff. A mL or so on the skin is barely detectable. SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org >> I'd guess bad breath, concerns over toxicity, and reactions between >> the drug and carrier. Doing a lot of guess work this morning ;-) > >I'd say that there is very little reaction since DMSO is a solvent widely >used in the preparation of pharmaceuticals (but is generally not itself a >feedstock). DMSO-d6 has great use as a NMR solvent; however, non-deuterated DMSO finds little use during synthetic work due to its high boiling point and the fact that it dissolves almost everything! Darryl. > >> I'd guess bad breath, concerns over toxicity, and reactions between > >> the drug and carrier. Doing a lot of guess work this morning ;-) [quoted text clipped - 6 lines] > finds little use during synthetic work due to its high boiling point > and the fact that it dissolves almost everything! It really is an amazing chemical once you start to look into its properties. SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org In fact, it is used as "active excipient" or absorption promoter (rather than "drug delivery system") in some proprietary medicinal products. I only know about Spanish products containing DMSO, but I suppose similar products could be found in other EU member States or third countries such as USA. As an example, VIRHERPES, a idoxuridine solution for topical use. You can notice DMSO smell, but you can stand it. > Why is this not widely used as a drug delivery system, esp for things like > skin? > Why is this not widely used as a drug delivery system, esp for things like > skin? It's widely used in bodybuilding circles for anabolic delivery. Problem is, it irritates skin, burns like fire, and makes your breath awful. Check out the dmso blister pic at www.Finaderm.com . I think I'll pass on dmso. Anything with 'pyrogenic' on the label has got to be left alone. > > Why is this not widely used as a drug delivery system, esp for things like > > skin? [quoted text clipped - 3 lines] > the dmso blister pic at www.Finaderm.com . I think I'll pass on dmso. > Anything with 'pyrogenic' on the label has got to be left alone. Pure DMSO *will* blister the skin. IIRC that's one of the reasons vets sometimes use the pure stuff. Ironically, a 90% soln will not, but is even better at delivering drugs than the 100% I suggest that the bodybuilders who use the 100% are morons. I've been using 80-90% on my face for a few weeks. It does no more than sting slightly, no worse than some aftershave, and not a trace of blister. SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org > Why is this not widely used as a drug delivery system, esp for things > like skin? Probably for some of the reasons mentioned (bad breath, etc.), though I do know that the product Pennsaid (diclofenac solution) contains DMSO. > > Why is this not widely used as a drug delivery system, esp for things > > like skin? > > Probably for some of the reasons mentioned (bad breath, etc.), though I do I had thought that bad breath was no problem until I was informed my breath smelled like a skunk died in there. Seems I rapidly got used to it and not noticed - I though the smell had gone away for some reason.. > know that the product Pennsaid (diclofenac solution) contains DMSO. What is it used for? Topical? SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org > > > Why is this not widely used as a drug delivery system, esp for things > > > like skin? [quoted text clipped - 10 lines] > What is it used for? > Topical? Got it. http://www.dimethaid.com/products/pennsaid.asp Now I can make my own up if needed! Although I have not noticed any side effects with diclofenac anyway, so it's a bit pointless. SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org > > > > Why is this not widely used as a drug delivery system, esp for things > > > > like skin? [quoted text clipped - 19 lines] > Although I have not noticed any side effects with diclofenac anyway, so it's > a bit pointless. BTW, is there data anywhere on the efficiency with which DMSO transports various drugs through the skin? SignatureDirk The Consensus:- The political party for the new millennium http://www.theconsensus.org > BTW, is there data anywhere on the efficiency with which DMSO > transports various drugs through the skin? I haven't seen any, sorry, though I'd expect it to vary widely depending on the drug. In any case, Pennsaid contains 1.5% diclofenac, and seems to get at least as good as, if not better results than 5% diclofenac compounded into Phlogel. >>BTW, is there data anywhere on the efficiency with which DMSO >>transports various drugs through the skin? [quoted text clipped - 4 lines] > at least as good as, if not better results than 5% diclofenac compounded > into Phlogel. Yesterday I came across some info on penetration efficiency. http://www.gaylordchemical.com/bulletins/Bulletin%20124%20USP%20Grade%20DMSO.pdf SignatureDirk The Consensus:- The political party for the new millenium http://www.theconsensus.org |
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