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Medical Forum / General / Pharmacy / March 2004Prednisone vs. Prednisolone
The vet has occasionally put my dog on Prednisone 20 mg. one twice daily for a short duration for a stiff neck/disc over the years. This last time it was Prednisolone 20 mg. but giving one and a half twice daily. What's the difference between the two and don't say the spelling. Thanks, Susan > The vet has occasionally put my dog on Prednisone 20 mg. one twice daily for > a short duration for a stiff neck/disc over the years. This last time it > was Prednisolone 20 mg. but giving one and a half twice daily. What's the > difference between the two and don't say the spelling. > Thanks, > Susan Prednisone is converted to prednisolone, the active form, in the human liver (apparently in dogs too, but I'm no veterinarian). Mg per mg, unless there are liver problems, they are essentially considered equivalent. Both Prednisone and Prednisolone are synthetic glucocorticoids that have short to medium acting anti-inflammatory properties. They differ in : 1. Chemical structure and molecular weight. 2. Prednisone is only administered orally. Prednisolone can be given orally, topically, or injected. 3. Prednisolone SLIGHTLY has a greater anti-inflammatory effect (not significant). Sam > The vet has occasionally put my dog on Prednisone 20 mg. one twice daily for > a short duration for a stiff neck/disc over the years. This last time it > was Prednisolone 20 mg. but giving one and a half twice daily. What's the > difference between the two and don't say the spelling. > Thanks, > Susan Thank you both for the information. The vet rattles things off so fast that sometimes it's hard to digest. Susan > Thank you both for the information. The vet rattles things off so fast that > sometimes it's hard to digest. > Susan > > 16 mg of prednisolone is equivalent in antiinflammatory activity to 20 mg of prednisone. 4 mg of prednisolone equiv to 5 mg of prednisone. Their chemical structures differ slightly, but each forms the other, and this reaction goes "back and forth." Scientifically, we would say they are "reversible metabolized to each other" As for dose, they are essentially equivalent.  SignatureHarold Boxenbaum, Ph.D. Pharmaceutical Consultant Arishel Inc. 14621 Settlers Landing Way North Potomac, MD 20878-4305 (P) 301-424-2806 (F) 301-424-8563 Email: harold@arishel.com Website: www.arishel.com > The vet has occasionally put my dog on Prednisone 20 mg. one twice daily for > a short duration for a stiff neck/disc over the years. This last time it > was Prednisolone 20 mg. but giving one and a half twice daily. What's the > difference between the two and don't say the spelling. > Thanks, > Susan |
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