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Medical Forum / General / Pharmacy / February 2004

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How are Rx Drugs Manufactured in General?

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Bill - 04 Feb 2004 15:23 GMT
I've been wondering about the high cost of some prescription drugs. I
suppose some are more costly than gold...

...Which gets me to thinking about what is in these drugs exactly. Are
there rare plants, bark, etc. in some of these drugs which is costly to
find and extract certain ingredients?

Or is the manufacturing process very complex or labor intensive? What is
involved in making an Rx drug? (Just the basic process in general please. I
don't want to make any myself, just want to understand what all is involved
in the manufacturing process...)

Are there any web pages which explain how Rx drugs are manufactured (In
general)?
Bruce Wade Hughes - 04 Feb 2004 16:15 GMT
If you can get a Goodman and Gilmans reference book you'll get more info
than you seek.

> I've been wondering about the high cost of some prescription drugs. I
> suppose some are more costly than gold...
[quoted text clipped - 10 lines]
> Are there any web pages which explain how Rx drugs are manufactured (In
> general)?
Nigel - 04 Feb 2004 17:53 GMT
> I've been wondering about the high cost of some prescription drugs. I
> suppose some are more costly than gold...
[quoted text clipped - 10 lines]
> Are there any web pages which explain how Rx drugs are manufactured
> (In general)?

You seem to be laboring under the asssumption that the retail price of a
drug should be connected to the manufacturing cost.

The cost of selling a drug comes long before manufacturing.  The company
must discover a potentailly important chemical, then through animal
testing prove that it is unlikely to cause harm if administered to
humans.  The company can then carry out the testing on humans to
demonstrate that the drug is both safe and effective.

8-12 years and $500 million to $1 billion later, the company can gain
approval to sell the drug.  In selling the drug, the company must cover
the cost of developing it, plus the cost of developing the ones that
din't work before the patents run out and anyone can sell it.

If you want a comparable, consider the software industry.  How much does
it cost to burn and ship a CD.  And if the software is delivered over the
internet, the manufacturing cost is effeectively $0.  Copying software is
certainly not difficult or labor intensive, so why is it so expensive?  
Infact, on a weight basis, software is far more expensive than many
drugs.

If you are interested in what it takes to bring a drug to market, take a
look at the PhaRMA website.
None@None.None - 13 Feb 2004 01:12 GMT
>...Which gets me to thinking about what is in these drugs exactly. Are
>there rare plants, bark, etc. in some of these drugs which is costly to
>find and extract certain ingredients?

Some drugs are semi-synthetic; cafergot, an ergot alkaloid, is a
semi-synthetic.  Most, if not all, SSRIs are synthetic--very simple
chemistry.  The goal of the industrial chemist is to obtain a very
pure product with as few steps as possible.  No exotic reagents and no
lengthy steps in purification--if it can't be scaled up to plant
production, it isn't worth it.  If a bug can ferment something and
yield a precursor, start there.  The closer to the target, the better.

Marketing and trials are where the big bucks are spent.
 
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