There is a public propelled movement going on to get products
containing ma huang (ephedra) or ephedrine products (e.g., ephedrine
hydrochloride [HCL]) off the market. In part this is understandable
only in regard to the fact the Drug Enforcement Agency (DEA) has
determined that ephedrine is a precursor of methamphetamine (speed),
meaning that large quantities of the substance ephedrine are used by
people running illegal laboratories to make illegal substances like
methamphetamine for sale and personal gain. The DEA has declared the
sale of large quantities of unadulterated ephedrine illegal,
quantities which are many times larger than one person could
legitimately consume in a month (or even longer). I support this
regulation and fully approve of the DEA's efforts to keep amphetamines
off the streets and out of any child's possession.
I will not speak of ma huang (ephedra) because I do not use it; for my
needs it does not work.
I am only writing to speak of ephedrine hlc and the fact many states
are banning the drug.
I suspect the federal government will follow suit as well within the
next five years.
Why are they trying to ban it? It is not because kids are trying to
make methamphetamine in their basement --- the allowable quantities
for sale are far too small for that sort of thing. The reason is
because ephedrine has very strong stimulant effects, almost as strong
as amphetamine (in those with zero tolerance of the drug). If people
do not read the instructions on the label (one 25mg tablet every four
hours, not to exceed six tablets in 24 hours) and if they take excess
amounts to realize the potent stimulant effects of the drug doing
this, and not following the instructions can kill people with
defective cardiovascular physiology. This has happened in the United
States and other countries a very small number of times, but every
time this happens the news media (ala Don Henley's "Dirty Laundry")
creates huge media publicity and as a result many people incorrectly
assume that ephedrine is even more toxic than nicotine (one of the
most toxic poisons around), or for that matter, aspirin.
If people do not read the instructions on any medicine bottle,
regardless of whether it is a prescription drug or OTC (over the
counter) serious adverse effects can and do occur.
For example, the Uchee Pines Institute
(http://www.ucheepines.org/pain_and_fever.htm) says:
Aspirin is a major cause of death in children up to 6 years of age,
accounting for more than 500 deaths from overdoses each year.
About 10,000 Americans each year lose their lives because of taking
aspirin. These deaths are entirely separate from accidental overdose
in children.
The Pittsburgh Post-Gazette (http://www.post-gazette.com/healthscience
/20030422hpainpills1.asp) states:
McNeil officials testified that Tylenol and other forms of
acetaminophen are safe if used as directed. They noted that about 100
deaths from accidental acetaminophen overdose are reported annually.
The Post-Gazette also reports that when all OTC pain killers including
aspirin are considered:
[A]n estimated 160,000 Americans end up in hospital emergency rooms
and about 16,000 die from complications related to the use of OTC
painkillers.
On the other hand a law related website
http://www.ephedrine-ephedra.com/ states [in the entire history of the
marketing of ephedrine or ephedrine-based products]:
The FDA believes that ephedra may be related to more than 50 deaths.
Most of the serious injuries involve high blood pressure that can
cause bleeding in the brain, a stroke or a heart attack.
What they fail to mention is the fact the drugs are taken in excess of
the directions on the label; they are also taken by people with weak
hearts.
Why is this of any concern to me? It is of concern to me for the very
reason stated on the bottle of "Mini-thins" sitting on my desk:
[Ephedrine] is a bronchodilator and it helps breathing without
drowsiness.
Why should this be of any concern to me?
I was a smoker from age 13 to age 34. Smoking had affected my
breathing drastically and I was on the verge of developing emphysema.
Even after I quit smoking, from age 34 until my present age of 52, I
have a lot of trouble breathing on high ozone days which frequently
occur on hot days in the summer. Lacking health insurance and
distaining public health clinics, I try to self-medicate whenever the
medications to do so are available over the counter.
One day I was in a convenience store and I saw a display of Mini-Thins
(ephedrine HCL 25mg. tablets) for sale. I read on the package "helps
breathing without drowsiness," and decided to try it. It worked. It
still works. It is wonderful and I can breathe easily and I have
avoided a $120 initial visit doctor bill as well as expensive
prescription medications.
I have been taking ephedrine regularly, AS DIRECTED, for almost two
decades with no adverse effects. Not only that, but heart disease runs
in the families of some painters and those who are heavy smokers with
bad diets. My grandfather painted with lead-based paints and he died
of a heart attack at age 43. My dad smoked four packs of cigarettes
per day and ate a diet rich in animal fats and he died at 47. I have
tried in every respect to avoid a toxic occupation and/or bad diet and
despite a history of heart disease in my family and despite my use of
ephedrine for nearly twenty years, I am in good physical health at age
fifty-two and it is my considered belief that my use of ephedrine
products, taken as directed, do not cause any harm whatsoever.
Abuse any drug and you may suffer negative consequences be it
aspirin, other OTC pain killers, or even ephedrine but do not punish
the educated and well-read on account of the misinformed and/or
illiterates. An illiterate cannot read "Walk / Don't Walk" signs
either, yet we do not put a uniformed police officer on every corner.
Educate yourself before you attempt to pass laws and ban products
without any conception of what you are doing or why you are doing it.
Aspirin killed many more children last year than ephedrine did in the
entire course of recent history.
Why don't you work to ban aspirin?
Why? Because you like it and it helps you?
Well, did you ever stop to consider ephedrine may help some people
too?
Think about it and let me know your thoughts on this. I am interested
in hearing what intelligent informed people have to say on this
subject.
Tony Safina
Louisville, Kentucky (vicinity)
tony@igloo.com
Change igloo to iglou to email me directly (and help keep spam out of
my mailbox)
Thanks.
Mxsmanic - 28 Jul 2003 11:05 GMT
> Think about it and let me know your thoughts on this. I am interested
> in hearing what intelligent informed people have to say on this
> subject.
I agree with everything you say, but I've never favored banning
ephedrine, anyway. In fact, I don't believe in banning or restricting
any drug, but my opinion is not widely held.

Signature
Transpose hotmail and mxsmanic in my e-mail address to reach me directly.
BilZ0r - 28 Jul 2003 23:59 GMT
> Why are they trying to ban it? It is not because kids are trying to
> make methamphetamine in their basement --- the allowable quantities
> for sale are far too small for that sort of thing. The reason is
> because ephedrine has very strong stimulant effects, almost as strong
> as amphetamine (in those with zero tolerance of the drug).
No, Most methamphetamine is made from (psuedo)ephidrine extracted from cold
pills. It is not as strong as amphetamine, as it has very little tyramine
like action. There is no reason for large amounts of ephidrine to be sold.
Mixing it with APAP and getting a better filler than just chalk should help
stop clandestine use.
Nomen Nescio - 29 Jul 2003 02:51 GMT
: No, Most methamphetamine is made from (psuedo)ephidrine extracted from cold
: pills. It is not as strong as amphetamine, as it has very little tyramine
: like action. There is no reason for large amounts of ephidrine to be sold.
: Mixing it with APAP and getting a better filler than just chalk should help
: stop clandestine use.
Pseudoephedrine is just as effetive as ephedrine in making "speed". The
two are basically interchangeable.
Darryl - 31 Jul 2003 13:29 GMT
>: No, Most methamphetamine is made from (psuedo)ephidrine extracted from cold
>: pills. It is not as strong as amphetamine, as it has very little tyramine
[quoted text clipped - 4 lines]
>Pseudoephedrine is just as effetive as ephedrine in making "speed". The
>two are basically interchangeable.
It's all about stereochemistry; when you lose the benzyllic alcohol in
(pseudo)-ephedrine, you'll end up with methamphetamine which, as other
posters have indicated, is more 'potent' than amphetamine. Moreover,
the procedure to convert ephedrine is quick and dirty and I would
guess that it's the favorite of all the local biker clubs. Therefore,
OTC ephedrine is probably the major source of precursor.
Darryl - 31 Jul 2003 13:30 GMT
>>: No, Most methamphetamine is made from (psuedo)ephidrine extracted from cold
>>: pills. It is not as strong as amphetamine, as it has very little tyramine
[quoted text clipped - 11 lines]
>guess that it's the favorite of all the local biker clubs. Therefore,
>OTC ephedrine is probably the major source of precursor.
p.s., if users stuck to the recommended dosage, ephedrine might be
considered safe, but I think even at those low levels, serious cardiac
effects are still a concern (as with any stimulant).
Tony Safina - 03 Aug 2003 08:30 GMT
> p.s., if users stuck to the recommended dosage, ephedrine might be
> considered safe, but I think even at those low levels, serious cardiac
> effects are still a concern (as with any stimulant).
So the FDA should ban coffee, chocolate, and tobacco? Do people
REALLY need protection from their own assinine behaviors? Far more
people die from abuses of some of these substances AND AS A RESULT OF
SERIOUS CARDIAC EFFECTS than have ever died from ephedrine use or
abuse.
Doesn't tobacco kill something close to 400,000 people per year?
Compare that to the 800 or fewer who have been adversely affected by
ephedrine (not even killed by it). In my opinion it is mostly a matter
of jobs, money, and politics as to why tobacco is still around in all
50 states and about 12 states have already banned ephedrine.
- Tony
Asger B - 31 Jul 2003 11:10 GMT
> > Why are they trying to ban it? It is not because kids are trying to
> > make methamphetamine in their basement --- the allowable quantities
[quoted text clipped - 5 lines]
> pills. It is not as strong as amphetamine, as it has very little tyramine
> like action.
Methamphetamine is stronger than amphetamine! It has longer period of
action, and is far more potent than amphetamine.
Furhtermore: Why not just make it a prescribtioned drug?? Ephedrine is a
powerful stimulant itself, as you have mentioned, and in several countries
in Europe, it is considered a serious drug, which is only sold Rx, actually
for weight loss (20 mg ephedrine/ 200 mg caffeine)
> Mixing it with APAP and getting a better filler than just chalk should help
> stop clandestine use.