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Medical Forum / General / Pharmacy / April 2004

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Low HDL - Niacin - Gout?

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Sully - 20 Dec 2003 23:12 GMT
Hi All,

I have been on 2 g Niaspan daily for 2 years with an increase in HDL
from 32 to 48. Quarterly blood checks have shown no adverse effects.
Recently I have been diagnosed with Gout. I have discussed options
with my Physician but I believe in studying many opinions. What is
your opinion on treatment for the low HDL in view of the Gout, and
what treatment would you recommend for the Gout?

I appreciate the opinions.

Mike Sullivan
Patrick Blanchard MD - 29 Dec 2003 08:10 GMT
I believe niacin is a most important medication for proper lipid metabolism.
I have not seen niacin cause gout in over 10 years of practice, but perhaps
I simply have not recognized it. Niacin can cause some insulin resistance
however, and has a frustrating rash as a common side effect *blocked by
aspirin*. You might try your question to sci.med.cardiology, they can give
you some great references on niacin. My website also has some interesting
articles about niacin and lipid metabolism.

As to my opinion on the rx for low HDL, I think it very important. In view
of gout, if your niacin is causing gout, I would recommend you focus on your
priorities; is having gout worth the benefit of increased HDL? No one can
decide that for you.

If you are taking other medications, you should also focus on them as a
cause. As for rx, my preference is colchicine, 0.6 mg  daily, trying diet
changes first, for at least 6 weeks. Paraffin soaks also work wonders.

I would like to hear from others regarding this lady's problem.

Regards,
Patrick

~~~
Patrick Blanchard, M.D.
Board Certified in Family Medicine

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Michael F. Poellot - 04 Apr 2004 12:25 GMT
>. . . <snip> Niacin can cause some insulin resistance
>however, and has a frustrating rash as a common side effect *blocked by
>aspirin*. You might try your question to sci.med.cardiology, they can give
>you some great references on niacin. My website also has some interesting
>articles about niacin and lipid metabolism.

sci.med.cardiology is an excellent forum to ask questions like this,
however, the reader will see "flame wars" going on at smc at the
present time. I recommend to ignore them and to read the relevant
topics there.

Michael
 
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