My husband has been taking Lisinopril for about four months. It made
him extremely tired. So much so that he was quite depressed.
The doctor has suggested he try Valsartan.
Can someone tell me the difference between the two. From what I've
read, fatigue is a common side effect of this drug so I'm not too
hopeful.
Also - the doctor is giving him these meds because there is protein in
his urine. She says that these drugs will improve his kidney function
and protect him from kidney failure. This also sounds strange since
possible side effects of both drugs are kidney problems.
I'm confused.
I want him to take what he needs to be healthy but he was so fatigued
that life was just no fun for him.
sudarshanpandit@gmail.com - 12 Jun 2008 16:47 GMT
> My husband has been taking Lisinopril for about four months. It made
> him extremely tired. So much so that he was quite depressed.
>
> The doctor has suggested he try Valsartan.
Find All information regarding Durgs on
>1. www.rxlist.com
2. www.drugs.com
3. try www.webmd.com
> Can someone tell me the difference between the two. From what I've
> read, fatigue is a common side effect of this drug so I'm not too
[quoted text clipped - 9 lines]
> I want him to take what he needs to be healthy but he was so fatigued
> that life was just no fun for him.
chorleydnc@gmail.com - 14 Jul 2008 14:28 GMT
> My husband has been taking Lisinopril for about four months. It made
> him extremely tired. So much so that he was quite depressed.
[quoted text clipped - 14 lines]
> I want him to take what he needs to be healthy but he was so fatigued
> that life was just no fun for him.
Valsartan is a good drug for this purpose, it has much lower side
effect profile than Lisinopril, but Lisinopril is much cheaper so the
doc was right to choose it first.
The fundamental reason both drugs reduce proteinuria is that they
reduce the pressure in the efferent renal arteriole, after the
glomerulus. Think of the glomerulus as a sponge filter, soccer ball
shaped, with an outlet for the clear fluid which eventually becomes
urine, and an outlet which contains the "good stuff" RBCs and proteins
etc.(that is the efferent arteriole) If you can open up the efferent
arteriole, then pressure across the filter in the glomerulus is
reduced and it doesn't get eroded. Therefore proteins do not slip into
the tubules that form the urine. If Proteins fill up the tubules, they
set up like jell-o and shut down your kidneys.
You can add Verapamil and it has a synergistic effect.
The doctor should have done a 24 hour urinary protein, Renal
ultrasounds, probably a biopsy and a mag-3 scan (which is a
radionucleotide scan that looks at perfusion and secretion).
It goes without saying that Smoking cessation, blood glucose control
and general blood pressure control is of absolute importance. If
autoimmune diseases have not been thought of, a rheumatological work
up would be necessary.
David