half life vs time to peak

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Mtr - 31 Oct 2007 22:35 GMT

How does a drug's half life relate to its time to peak plasma
concentration? They would generally seem to be somewhat similar, with PPC
preceding the half life by some measure. Is that correct?

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Dr. Wayne Simon - 01 Nov 2007 01:52 GMT

> How does a drug's half life relate to its time to peak plasma
> concentration? They would generally seem to be somewhat similar, with
> PPC preceding the half life by some measure. Is that correct?

Time to peak is related to a drugs administration route, and or absorption,
while half life is related to its elimination rate. When a drug is rapidly
absorbed or injected directly into the circulatory system, halflife has very
little to do with time to peak, however is a drug is administered very
slowly, or has a very slow absorption rate, then there can be a
relationship.

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