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Medical Forum / General / Pharmacy / July 2007

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Autoimmune .. treatment ..?

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ironjustice - 06 Jul 2007 21:39 GMT
Topically applied lecithin .. ?

MMP-1 is inhibited by lecithin / phytic acid ..

J Autoimmun 2002 Nov;19(3):161-8

These results indicated that the over-expression of MMP-1 in RA SF
might be
related to the activation of DDR2, and collagen II, act as DDR2
ligand, might
be one of the stimulators of the over-expression of MMP-1 of RA SF.

PMID: 12419287, UI: 22307318

--------------------------------------------------------------------------
------

This article specifically states .. MMP-1 is TOTALLY ABOLISHED by
phytic acid.

<<snip>>
Phytic acid, a naturally occurring compound present in food, is an
anti-angiogenic compound because it inhibits the activation of pro-
MMP-1 and
the activity of MMP-1.
<<snip>>

23
Interaction of metalloproteinase-1 (MMP-1) with phytic acid:
Antiangiogenic
activity of phytic acid
R. R. BANSODE and J. N. Losso. Food Science, Louisiana State
University, 111
Food Science Building, Louisiana State University, Baton Rouge, LA
70803

There is strong evidence that metalloproteinases (MMPs) participate
in
cardiovascular diseases, angiogenesis, tumor growth, and metastasis.
Gelatinase
I (MMP-1), is secreted as an inactive proenzyme (pro-MMP-1) and must
be
activated before it can act as a catalyst of collagen degradation.
Activators
of pro-MMP-1 include serine proteinases and prooxidants. In most
chronic
diseases, such as cancer, arthritis, inflammation, and diabetes, the
concentration of endogenous inhibitors is often low to counteract the
action of
over expressed proteinases. Inhibitors of MMPs are thus attractive
targets for
degenerative disease prevention and possibly treatment. Phytic acid
(myo-inositol hexaphosphate) is naturally occurring in dicotyledonous
and
monocotyledonous seeds. Although an inverse relationship between
phytic acid
concentration in the diet and cancer rate has been demonstrated, the
mechanism
by which phytic acid may reduce cancer has not been fully explained.

The objective of this research was to determine the ability and
minimum
concentration of phytic acid to inactivate the activation of pro-MMP1
in an
effort to delay the onset and progression of basement degradation and
the
progression of angiogenesis.

The inhibition of pro-MMP-1 activation by phytic acid was investigated
using
biotinylated gelatin, gelatin zymography, electrophoresis with silver
staining,
and fluorescence quenched substrate hydrolysis. Phytic acid at
concentration of
40 nM completely inhibited trypsin activation of pro-MMP-1.
Quantitation of
gelatinolytic activity of phytic acid -treated trypsin-activated pro-
MMP-1
demonstrated the absence of gelatin degradation. Silver staining
showed the
pattern of BBI inactivation of pro-MMP-1 activation with increased
concentration of phytic. Lower rate of substrate hydrolysis following
quenched
fluorescence substrate hydrolysis was inversely proportional to the
concentration of phytic acid present in the reaction medium.

Phytic acid, a naturally occurring compound present in food, is an
anti-angiogenic compound because it inhibits the activation of pro-
MMP-1 and
the activity of MMP-1.

Session 6, Biotechnology
8:30 AM - 12:00 PM, 2002-06-18
-------------------------------------------------------

There was a question as to whether topically applied lecithin would
be
efficacious ..

The article shows it .. is ..

This article ALSO shows it / oil crosses the skin / epidermis.

http://www.indianpediatrics.net/oct2005/oct-998-1005.htm

Indian Pediatrics 2005; 42:998-1005

Transcutaneous Absorption of Topically Massaged Oil in Neonates

Kirti Solanki, Manoj Matnani, +Mrudula Kale, +Kalpana Joshi, Ashish
Bavdekar, Sheila Bhave and Anand Pandit

>From the *Department of Pediatrics, KEM Hospital, Pune 411 011, India

and +School of Health Sciences, University of Pune, Pune 411 007,
India.

Address for Correspondence : Dr. Sheila Bhave, Department of
Pediatrics, KEM Hospital, Pune 411 011, India. E-mail:
kem...@vsnl.com

Abstract

Objective:
To study the transcutaneous absorption of traditionally
massaged oil in newborns and to specifically compare the effects of
(i)
essential fatty acid (EFA) rich - safflower oil and (ii) saturated
fat
rich coconut oil, on fatty acid profiles of massaged babies. Design:
A
short term randomised controlled study.
Setting:
Tertiary care NICU of a large teaching hospital and a research
laboratory
of a University complex.
Methods:
120 study babies were randomly assigned to three oil
groups (i) safflower oil (n = 40) (ii) coconut oil (n = 40) and (iii)
no oil controls (n = 40). In each group, babies were selected in
three
subsets as per their gestational ages viz., (a) <34weeks, (b) 34-37
weeks, (c) > 37 weeks. 5 mL of the designated oil was massaged four
times a day (6hrly) for five days under controlled conditions of
temperature and feeding. Pre and post oil massage samples of blood
were
analysed for triglycerides and fatty acid profiles using gas
chromatography.
Results:
Post oil triglyceride values were significantly raised in both the oil
groups
and also in controls.
However, the quantum of rise was significantly higher in oil groups
as
compared to controls (p <0.05). Fatty acid profiles (gas
chromatography) showed significant rise in EFAs (linolenic acid and
arachidonic acid) in safflower oil group and saturated fats in
coconut
oil group (p <0.05). Changes were more evident in term babies. There
were no side effects associated with the massage.
Conclusion:
This study shows that topically applied oil can be absorbed in
neonates and
is probably available for nutritional purposes. The fatty acid
constituents of the oil can influence the changes in the fatty acid
profiles of the massaged babies.

Key words: Fatty acid profile, Topical absorption, Traditional oil .

-----------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Joe_Z - 07 Jul 2007 00:18 GMT
IJ, they say they have cured cancer but no one was watching, I believe it
was a vitamin or mineral they used, got any info? just a
thought...Hoping_Joe

> Topically applied lecithin .. ?
>
[quoted text clipped - 178 lines]
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
ironjustice - 07 Jul 2007 19:02 GMT
>> On Jul 6, 4:18 pm, "Joe_Z" <J...@botkiller.com> wrote:
IJ, they say they have cured cancer but no one was watching, I
believe it
was a vitamin or mineral they used, got any info? just a
thought...Hoping_Joe <<

Actually .. Joe .. using science .. the lecithin .. topical
lecithin .. is what you might be talking about .. the "they say they
have cured cancer but no one was watching" .. part of your .. post.

Lecithin according to chemists is one and the same as .. unleavened
bread / phytic acid.

The chemical 'constituents' .. IE: phosphate groups.

Sooo .. as the study shows the topical application of .. oil .. causes
the lipids in the body to .. change .. therefore giving conclusive
evidence / along with the hairless mouse studies .. THAT the
constituents / phosphates .. ARE .. crossing the epidermis .. and
since phytic acid medical studies concerning its' .. efficaciousness /
curing ability ..  ARE .. numerous .. ?

The lecithin it seems delivers the SAME 'constituents' INTO the
body .. compared to taking phytic acid / IP6 by mouth or theoretically
even .. intravenously.

It is the dose which they suspect is not 'equivalent' to these high
doses used in studies.

But theoretically ..

>From http://ip-6.net/HomePage.html
"Dr. AbulKalam M. Shamsuddin MD, PhD, is Professor of Pathology at
the
University of Maryland School of Medicine in Baltimore. Since 1975,
he
has been researching the processes of cancer formation, cancer
prevention and cancer treatment. Inventor of a rapid, simple and
inexpensive screening test for cancer [US Patent #5,348,860] he is
also the pioneering scientist to demonstrate the immune enhancing and
anti-cancer actions of IP-6 & Inositol, for which he was awarded the
US patent #5,082,833; European Patent # 0 422 109; Japanese Patent
#3188897."

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

> > Topically applied lecithin .. ?
>
[quoted text clipped - 180 lines]
>
> - Show quoted text -
ironjustice - 07 Jul 2007 19:13 GMT
<<snip>>
IP6 deserves further study in the treatment of oral cavity squamous
cell carcinoma
<<snip>>

Laryngoscope. 2007 Jun 29; [Epub ahead of print] Links
Inositol Hexaphosphate and Paclitaxel: Symbiotic Treatment of Oral
Cavity Squamous Cell Carcinoma.
Janus SC, Weurtz B, Ondrey FG.
>From the Department of Otolaryngology, University of Minnesota,
Minneapolis, Minnesota, U.S.A.

OBJECTIVES/HYPOTHESIS:: Nuclear factor (NF)-kappaB is an early
response gene that has been associated with head and neck squamous
cell cancer (HNSCC) progression. NF-kappaB activation is induced by
some chemotherapy agents, including paclitaxel. The activation of this
gene can be correlated with apoptosis resistance. Inositol
hexaphosphate (IP6) is a naturally occurring polyphosphorylated
carbohydrate. NF-kappaB levels were evaluated in oral cavity HNSCC
lines after treatment with paclitaxel and IP6, alone and in
combination. Resulting levels of cell death and apoptosis were
assessed, and conclusions are drawn regarding a possible synergistic
relationship between paclitaxel and IP6. METHODS:: NF-kappaB
activation in cancer cells treated with paclitaxel and IP6, alone and
in combination, was measured by transient transfection, and results
were interpreted by luminometry. Cell proliferation of treated cells
was measured by MTT assay. Cell viability and apoptosis of cancer
cells treated with paclitaxel and IP6 combinations were quantitated by
trypan blue staining and Caspase-Glo 3/7 assay, respectively.
RESULTS:: IP6 was observed to significantly downregulate NF-kappaB
activation in both NA and CA-9-22 oral cavity HNSCC cell lines.
Paclitaxel treatments caused increased NF-kappaB activation in the
same cell lines. IP6 was observed to mitigate paclitaxel-induced NF-
kappaB activation in the CA-9-22 cell line. IP6, when combined with
paclitaxel, reduces CA-9-22 cell proliferation, increases cell death,
and increases apoptosis, when compared with treatment with paclitaxel
alone. CONCLUSIONS:: IP6 reduces paclitaxel induced NF-kappaB
activation and increases paclitaxel-mediated cell killing and
apoptosis. As a well-tolerated and safe supplement, IP6 deserves
further study in the treatment of oral cavity squamous cell carcinoma.

PMID: 17607147 [PubMed - as supplied by publisher]
ironjustice - 07 Jul 2007 19:25 GMT
<<snip>>
Lots of phosphates in lecithin
<<snip>>

http://forum.bodybuilding.com/showthread.php?t=629544

What Is It?

Lecithin is a fatty substance manufactured in the body and widely
found in many animal- and plant-based foods, including eggs, liver,
peanuts, soybeans, and wheat germ. Lecithin is often used as an
additive in such processed foods as ice cream, margarine, and salad
dressings, because it helps blend (or emulsify) fats with water.
Lecithin is also available in supplement form.

Lecithin is considered an excellent source of choline, one of the B
vitamins. Once in the body, a key component of lecithin--
phosphatidylcholine--breaks down into choline. Now available in
dietary supplement form, phosphatidylcholine (PC) might be thought of
as a purified extract of lecithin. It is commonly recommended for
treating liver, nerve, and a variety of other conditions, including
multiple sclerosis and memory loss.

Although dietary lecithin is the primary source of choline, this
nutrient is also available through food; it appears in high
concentrations in liver, egg yolks, peanuts, cauliflower, soybeans,
grape juice, and cabbage. Choline is also present in concentrated form
in various B-complex vitamins.

Most North Americans get enough lecithin and choline in their daily
diets, and deficiencies are rare. That's fortunate because every cell
in the human body needs these nutrients to function properly.

Health Benefits

Lecithin and choline help form cell membranes and transport fats and
nutrients into and out of cells. They are also involved in human
reproduction and fetal and infant development. In fact, choline must
be included in all FDA-approved infant formulas.

These nutrients also play a vital role in keeping the nervous system
healthy.

Specifically, phosphatidylcholine, and in some cases lecithin or
choline alone, may help to:

Treat memory loss or impairment. Many nutritionally oriented doctors
consider phosphatidylcholine a valuable nerve-building nutrient that
might be able to help slow or reverse memory loss. As a phospholipid--
a fat-soluble substance--this nutrient serves as a major structural
component of brain cells.

Perhaps even more important, phosphatidylcholine plays a key role in
supplying sufficient choline to the brain, where it's used to
manufacture the neurotransmitter acetylcholine. Levels of
acetylcholine are known to dwindle with age and this decline is
associated with age-related memory impairment.

In one study involving rats, mothers given extra choline produced
offspring with memory and learning skills superior to the offspring of
those rats on a regular diet. And the offspring of mothers whose diet
was deficient in choline performed poorly on memory tests. There have
been no human trials to test phosphatidylcholine's effectiveness for
memory or nerve problems in humans, however.

Protect the liver from alcohol abuse and hepatitis.
Phosphatidylcholine is believed to speed the flow of fats and
cholesterol through the liver, prevent the buildup of fats within the
liver, and assist the liver in eliminating dangerous toxins from the
body.

A 10-year study of baboons found that lecithin prevents two serious
side effects of alcohol abuse: severe liver scarring and cirrhosis.
Other research suggests that it may also be suitable for liver
problems caused by hepatitis. There are no human studies so far,
however.

Choline is frequently found in combination with such liver-
strengthening ingredients as the B vitamin inositol, the amino acid
methionine, and the herbs dandelion and milk thistle in preparations
called lipotropic combinations.

Prevent gallstones. Low levels of lecithin, an important constituent
of the fat-digesting substance known as bile, may promote gallstones.
That's why taking lecithin supplements (or its purified extract,
phosphatidylcholine) may help to avert often painful gallstones.

Recommended Intake

There are no RDAs for these nutrients, but scientists have established
an Adequate Intake for choline: 550 mg a day for men and 425 mg for
women.

If You Get Too Little

Lecithin and choline deficiencies are rare.

If You Get Too Much

High doses of lecithin and choline can produce such side effects as
sweating, nausea, vomiting, bloating, and diarrhea. Extremely large
doses of choline (10 grams a day) can cause a fishy body odor or a
heart-rhythm abnormality.

General Dosage Information

Most Americans get enough of these nutrients in their daily diet--
about 6 grams of lecithin and up to 1 gram of choline.

Guidelines for Use
Although both lecithin and choline are available as individual
supplements, the most effective way to elevate choline levels in the
body is to take phosphatidylcholine. (Another reason not to take
individual choline supplements is that large amounts have been known
to produce a fishlike smell in the user.)
To enhance absorption, take phosphatidylcholine with meals.
Consider sprinkling granular lecithin over foods or adding it to
drinks. It has a nutty flavor.

General Interaction

There are no known drug or nutrient interactions associated with
lecithin, choline, or phosphatidylcholine taken in commonly
recommended dosages.

Cautions
Because individual phosphatidylcholine, lecithin, or choline
supplements can increase levels of acetylcholine, they should not be
used by individuals who are suffering from bipolar disorder. High
levels of acetylcholine can worsen the "depressive" phase of this
condition.
Consult your doctor before taking phosphatidylcholine if you suffer
from depression; it may worsen your condition.
__________________
MET-Rx Board Rep

*Disclaimer: My thoughts and opinions do not reflect MET-Rx as a
company. I am not employed by them, I am simply here to answer
questions regarding their products.*

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Joe_Z - 08 Jul 2007 13:45 GMT
I took lecithin for close to a year in the early 80's cuz I got it real
cheap and the wife was into that scene at the time, it seemed to help but it
was a long time ago...Joe

> <<snip>>
> Lots of phosphates in lecithin
[quoted text clipped - 147 lines]
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
Joe_Z - 08 Jul 2007 13:49 GMT
Thanks, great info and we will be real suprised when it's shown what natural
treatment can do in the future IMHO...Joe

>>> On Jul 6, 4:18 pm, "Joe_Z" <J...@botkiller.com> wrote:
> IJ, they say they have cured cancer but no one was watching, I
[quoted text clipped - 236 lines]
>>
>> - Show quoted text -
 
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