Medical Forum / General / Pharmacy / July 2007
Autoimmune .. treatment ..?
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ironjustice - 06 Jul 2007 21:39 GMT Topically applied lecithin .. ?
MMP-1 is inhibited by lecithin / phytic acid ..
J Autoimmun 2002 Nov;19(3):161-8
These results indicated that the over-expression of MMP-1 in RA SF might be related to the activation of DDR2, and collagen II, act as DDR2 ligand, might be one of the stimulators of the over-expression of MMP-1 of RA SF.
PMID: 12419287, UI: 22307318
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This article specifically states .. MMP-1 is TOTALLY ABOLISHED by phytic acid.
<<snip>> Phytic acid, a naturally occurring compound present in food, is an anti-angiogenic compound because it inhibits the activation of pro- MMP-1 and the activity of MMP-1. <<snip>>
23 Interaction of metalloproteinase-1 (MMP-1) with phytic acid: Antiangiogenic activity of phytic acid R. R. BANSODE and J. N. Losso. Food Science, Louisiana State University, 111 Food Science Building, Louisiana State University, Baton Rouge, LA 70803
There is strong evidence that metalloproteinases (MMPs) participate in cardiovascular diseases, angiogenesis, tumor growth, and metastasis. Gelatinase I (MMP-1), is secreted as an inactive proenzyme (pro-MMP-1) and must be activated before it can act as a catalyst of collagen degradation. Activators of pro-MMP-1 include serine proteinases and prooxidants. In most chronic diseases, such as cancer, arthritis, inflammation, and diabetes, the concentration of endogenous inhibitors is often low to counteract the action of over expressed proteinases. Inhibitors of MMPs are thus attractive targets for degenerative disease prevention and possibly treatment. Phytic acid (myo-inositol hexaphosphate) is naturally occurring in dicotyledonous and monocotyledonous seeds. Although an inverse relationship between phytic acid concentration in the diet and cancer rate has been demonstrated, the mechanism by which phytic acid may reduce cancer has not been fully explained.
The objective of this research was to determine the ability and minimum concentration of phytic acid to inactivate the activation of pro-MMP1 in an effort to delay the onset and progression of basement degradation and the progression of angiogenesis.
The inhibition of pro-MMP-1 activation by phytic acid was investigated using biotinylated gelatin, gelatin zymography, electrophoresis with silver staining, and fluorescence quenched substrate hydrolysis. Phytic acid at concentration of 40 nM completely inhibited trypsin activation of pro-MMP-1. Quantitation of gelatinolytic activity of phytic acid -treated trypsin-activated pro- MMP-1 demonstrated the absence of gelatin degradation. Silver staining showed the pattern of BBI inactivation of pro-MMP-1 activation with increased concentration of phytic. Lower rate of substrate hydrolysis following quenched fluorescence substrate hydrolysis was inversely proportional to the concentration of phytic acid present in the reaction medium.
Phytic acid, a naturally occurring compound present in food, is an anti-angiogenic compound because it inhibits the activation of pro- MMP-1 and the activity of MMP-1.
Session 6, Biotechnology 8:30 AM - 12:00 PM, 2002-06-18 -------------------------------------------------------
There was a question as to whether topically applied lecithin would be efficacious ..
The article shows it .. is ..
This article ALSO shows it / oil crosses the skin / epidermis.
http://www.indianpediatrics.net/oct2005/oct-998-1005.htm
Indian Pediatrics 2005; 42:998-1005
Transcutaneous Absorption of Topically Massaged Oil in Neonates
Kirti Solanki, Manoj Matnani, +Mrudula Kale, +Kalpana Joshi, Ashish Bavdekar, Sheila Bhave and Anand Pandit
>From the *Department of Pediatrics, KEM Hospital, Pune 411 011, India and +School of Health Sciences, University of Pune, Pune 411 007, India.
Address for Correspondence : Dr. Sheila Bhave, Department of Pediatrics, KEM Hospital, Pune 411 011, India. E-mail: kem...@vsnl.com
Abstract
Objective: To study the transcutaneous absorption of traditionally massaged oil in newborns and to specifically compare the effects of (i) essential fatty acid (EFA) rich - safflower oil and (ii) saturated fat rich coconut oil, on fatty acid profiles of massaged babies. Design: A short term randomised controlled study. Setting: Tertiary care NICU of a large teaching hospital and a research laboratory of a University complex. Methods: 120 study babies were randomly assigned to three oil groups (i) safflower oil (n = 40) (ii) coconut oil (n = 40) and (iii) no oil controls (n = 40). In each group, babies were selected in three subsets as per their gestational ages viz., (a) <34weeks, (b) 34-37 weeks, (c) > 37 weeks. 5 mL of the designated oil was massaged four times a day (6hrly) for five days under controlled conditions of temperature and feeding. Pre and post oil massage samples of blood were analysed for triglycerides and fatty acid profiles using gas chromatography. Results: Post oil triglyceride values were significantly raised in both the oil groups and also in controls. However, the quantum of rise was significantly higher in oil groups as compared to controls (p <0.05). Fatty acid profiles (gas chromatography) showed significant rise in EFAs (linolenic acid and arachidonic acid) in safflower oil group and saturated fats in coconut oil group (p <0.05). Changes were more evident in term babies. There were no side effects associated with the massage. Conclusion: This study shows that topically applied oil can be absorbed in neonates and is probably available for nutritional purposes. The fatty acid constituents of the oil can influence the changes in the fatty acid profiles of the massaged babies.
Key words: Fatty acid profile, Topical absorption, Traditional oil .
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Who loves ya. Tom
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Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Joe_Z - 07 Jul 2007 00:18 GMT IJ, they say they have cured cancer but no one was watching, I believe it was a vitamin or mineral they used, got any info? just a thought...Hoping_Joe
> Topically applied lecithin .. ? > [quoted text clipped - 178 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk ironjustice - 07 Jul 2007 19:02 GMT >> On Jul 6, 4:18 pm, "Joe_Z" <J...@botkiller.com> wrote: IJ, they say they have cured cancer but no one was watching, I believe it was a vitamin or mineral they used, got any info? just a thought...Hoping_Joe <<
Actually .. Joe .. using science .. the lecithin .. topical lecithin .. is what you might be talking about .. the "they say they have cured cancer but no one was watching" .. part of your .. post.
Lecithin according to chemists is one and the same as .. unleavened bread / phytic acid.
The chemical 'constituents' .. IE: phosphate groups.
Sooo .. as the study shows the topical application of .. oil .. causes the lipids in the body to .. change .. therefore giving conclusive evidence / along with the hairless mouse studies .. THAT the constituents / phosphates .. ARE .. crossing the epidermis .. and since phytic acid medical studies concerning its' .. efficaciousness / curing ability .. ARE .. numerous .. ?
The lecithin it seems delivers the SAME 'constituents' INTO the body .. compared to taking phytic acid / IP6 by mouth or theoretically even .. intravenously.
It is the dose which they suspect is not 'equivalent' to these high doses used in studies.
But theoretically ..
>From http://ip-6.net/HomePage.html "Dr. AbulKalam M. Shamsuddin MD, PhD, is Professor of Pathology at the University of Maryland School of Medicine in Baltimore. Since 1975, he has been researching the processes of cancer formation, cancer prevention and cancer treatment. Inventor of a rapid, simple and inexpensive screening test for cancer [US Patent #5,348,860] he is also the pioneering scientist to demonstrate the immune enhancing and anti-cancer actions of IP-6 & Inositol, for which he was awarded the US patent #5,082,833; European Patent # 0 422 109; Japanese Patent #3188897."
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
> > Topically applied lecithin .. ? > [quoted text clipped - 180 lines] > > - Show quoted text - ironjustice - 07 Jul 2007 19:13 GMT <<snip>> IP6 deserves further study in the treatment of oral cavity squamous cell carcinoma <<snip>>
Laryngoscope. 2007 Jun 29; [Epub ahead of print] Links Inositol Hexaphosphate and Paclitaxel: Symbiotic Treatment of Oral Cavity Squamous Cell Carcinoma. Janus SC, Weurtz B, Ondrey FG.
>From the Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, U.S.A.
OBJECTIVES/HYPOTHESIS:: Nuclear factor (NF)-kappaB is an early response gene that has been associated with head and neck squamous cell cancer (HNSCC) progression. NF-kappaB activation is induced by some chemotherapy agents, including paclitaxel. The activation of this gene can be correlated with apoptosis resistance. Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate. NF-kappaB levels were evaluated in oral cavity HNSCC lines after treatment with paclitaxel and IP6, alone and in combination. Resulting levels of cell death and apoptosis were assessed, and conclusions are drawn regarding a possible synergistic relationship between paclitaxel and IP6. METHODS:: NF-kappaB activation in cancer cells treated with paclitaxel and IP6, alone and in combination, was measured by transient transfection, and results were interpreted by luminometry. Cell proliferation of treated cells was measured by MTT assay. Cell viability and apoptosis of cancer cells treated with paclitaxel and IP6 combinations were quantitated by trypan blue staining and Caspase-Glo 3/7 assay, respectively. RESULTS:: IP6 was observed to significantly downregulate NF-kappaB activation in both NA and CA-9-22 oral cavity HNSCC cell lines. Paclitaxel treatments caused increased NF-kappaB activation in the same cell lines. IP6 was observed to mitigate paclitaxel-induced NF- kappaB activation in the CA-9-22 cell line. IP6, when combined with paclitaxel, reduces CA-9-22 cell proliferation, increases cell death, and increases apoptosis, when compared with treatment with paclitaxel alone. CONCLUSIONS:: IP6 reduces paclitaxel induced NF-kappaB activation and increases paclitaxel-mediated cell killing and apoptosis. As a well-tolerated and safe supplement, IP6 deserves further study in the treatment of oral cavity squamous cell carcinoma.
PMID: 17607147 [PubMed - as supplied by publisher]
ironjustice - 07 Jul 2007 19:25 GMT <<snip>> Lots of phosphates in lecithin <<snip>>
http://forum.bodybuilding.com/showthread.php?t=629544
What Is It?
Lecithin is a fatty substance manufactured in the body and widely found in many animal- and plant-based foods, including eggs, liver, peanuts, soybeans, and wheat germ. Lecithin is often used as an additive in such processed foods as ice cream, margarine, and salad dressings, because it helps blend (or emulsify) fats with water. Lecithin is also available in supplement form.
Lecithin is considered an excellent source of choline, one of the B vitamins. Once in the body, a key component of lecithin-- phosphatidylcholine--breaks down into choline. Now available in dietary supplement form, phosphatidylcholine (PC) might be thought of as a purified extract of lecithin. It is commonly recommended for treating liver, nerve, and a variety of other conditions, including multiple sclerosis and memory loss.
Although dietary lecithin is the primary source of choline, this nutrient is also available through food; it appears in high concentrations in liver, egg yolks, peanuts, cauliflower, soybeans, grape juice, and cabbage. Choline is also present in concentrated form in various B-complex vitamins.
Most North Americans get enough lecithin and choline in their daily diets, and deficiencies are rare. That's fortunate because every cell in the human body needs these nutrients to function properly.
Health Benefits
Lecithin and choline help form cell membranes and transport fats and nutrients into and out of cells. They are also involved in human reproduction and fetal and infant development. In fact, choline must be included in all FDA-approved infant formulas.
These nutrients also play a vital role in keeping the nervous system healthy.
Specifically, phosphatidylcholine, and in some cases lecithin or choline alone, may help to:
Treat memory loss or impairment. Many nutritionally oriented doctors consider phosphatidylcholine a valuable nerve-building nutrient that might be able to help slow or reverse memory loss. As a phospholipid-- a fat-soluble substance--this nutrient serves as a major structural component of brain cells.
Perhaps even more important, phosphatidylcholine plays a key role in supplying sufficient choline to the brain, where it's used to manufacture the neurotransmitter acetylcholine. Levels of acetylcholine are known to dwindle with age and this decline is associated with age-related memory impairment.
In one study involving rats, mothers given extra choline produced offspring with memory and learning skills superior to the offspring of those rats on a regular diet. And the offspring of mothers whose diet was deficient in choline performed poorly on memory tests. There have been no human trials to test phosphatidylcholine's effectiveness for memory or nerve problems in humans, however.
Protect the liver from alcohol abuse and hepatitis. Phosphatidylcholine is believed to speed the flow of fats and cholesterol through the liver, prevent the buildup of fats within the liver, and assist the liver in eliminating dangerous toxins from the body.
A 10-year study of baboons found that lecithin prevents two serious side effects of alcohol abuse: severe liver scarring and cirrhosis. Other research suggests that it may also be suitable for liver problems caused by hepatitis. There are no human studies so far, however.
Choline is frequently found in combination with such liver- strengthening ingredients as the B vitamin inositol, the amino acid methionine, and the herbs dandelion and milk thistle in preparations called lipotropic combinations.
Prevent gallstones. Low levels of lecithin, an important constituent of the fat-digesting substance known as bile, may promote gallstones. That's why taking lecithin supplements (or its purified extract, phosphatidylcholine) may help to avert often painful gallstones.
Recommended Intake
There are no RDAs for these nutrients, but scientists have established an Adequate Intake for choline: 550 mg a day for men and 425 mg for women.
If You Get Too Little
Lecithin and choline deficiencies are rare.
If You Get Too Much
High doses of lecithin and choline can produce such side effects as sweating, nausea, vomiting, bloating, and diarrhea. Extremely large doses of choline (10 grams a day) can cause a fishy body odor or a heart-rhythm abnormality.
General Dosage Information
Most Americans get enough of these nutrients in their daily diet-- about 6 grams of lecithin and up to 1 gram of choline.
Guidelines for Use Although both lecithin and choline are available as individual supplements, the most effective way to elevate choline levels in the body is to take phosphatidylcholine. (Another reason not to take individual choline supplements is that large amounts have been known to produce a fishlike smell in the user.) To enhance absorption, take phosphatidylcholine with meals. Consider sprinkling granular lecithin over foods or adding it to drinks. It has a nutty flavor.
General Interaction
There are no known drug or nutrient interactions associated with lecithin, choline, or phosphatidylcholine taken in commonly recommended dosages.
Cautions Because individual phosphatidylcholine, lecithin, or choline supplements can increase levels of acetylcholine, they should not be used by individuals who are suffering from bipolar disorder. High levels of acetylcholine can worsen the "depressive" phase of this condition. Consult your doctor before taking phosphatidylcholine if you suffer from depression; it may worsen your condition. __________________ MET-Rx Board Rep
*Disclaimer: My thoughts and opinions do not reflect MET-Rx as a company. I am not employed by them, I am simply here to answer questions regarding their products.*
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Joe_Z - 08 Jul 2007 13:45 GMT I took lecithin for close to a year in the early 80's cuz I got it real cheap and the wife was into that scene at the time, it seemed to help but it was a long time ago...Joe
> <<snip>> > Lots of phosphates in lecithin [quoted text clipped - 147 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk Joe_Z - 08 Jul 2007 13:49 GMT Thanks, great info and we will be real suprised when it's shown what natural treatment can do in the future IMHO...Joe
>>> On Jul 6, 4:18 pm, "Joe_Z" <J...@botkiller.com> wrote: > IJ, they say they have cured cancer but no one was watching, I [quoted text clipped - 236 lines] >> >> - Show quoted text -
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