Why metoprolol with food?

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Salmon Egg - 18 May 2007 05:09 GMT

My metoprolol comes with an admonition to take with food. Why? Is it to slow
down absorption? Could food actually speed up absorption?

Bill
-- Fermez le Bush--about two years to go.

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HankG - 20 May 2007 14:24 GMT

> My metoprolol comes with an admonition to take with food. Why? Is it to slow
> down absorption? Could food actually speed up absorption?
[quoted text clipped - 3 lines]
>
> I find it quite irritating to my stomach if not followed with a small

snack. I'm on 2 a day. Take the first one immediately before breakfast;
the second usually in the 4 - 5 PM area with a slice of buttered bread and
some V8.

HankG

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Salmon Egg - 20 May 2007 19:42 GMT

On 5/20/07 6:24 AM, in article 8f6dndfr2eaf0c3bnZ2dnUVZ_gydnZ2d@comcast.com,

> I find it quite irritating to my stomach if not followed with a small
> snack. I'm on 2 a day. Take the first one immediately before breakfast;
> the second usually in the 4 - 5 PM area with a slice of buttered bread and
> some V8.
>
> HankG

That is subjective. Are there pharmaceutical reasons?

Bill
-- Fermez le Bush--about two years to go.

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marindi.irmelize@gmail.com - 25 May 2007 19:12 GMT

> On 5/20/07 6:24 AM, in article 8f6dndfr2eaf0c3bnZ2dnUVZ_gydn...@comcast.com,
>
[quoted text clipped - 9 lines]
> Bill
> -- Fermez le Bush--about two years to go.

Bill,

Metoprolol is lipid soluble, which are metabolized extensively to be
eliminated by the kidneys. They are subjective to hepatic "first
pass" metabolism after oral administration. The plasma concentration
of drugs subject to extensive hepatic first pass metabolism vary
greatly between subjects because the process is so much affected by
two highly variable factors,
(1) speed of absorption
(2) hepatic blood flow,
of which the latter is the rate-
limiting factor.

The bioavailability (availablity of the drug) may be increased by
ingestion of food and during long-term administration of the drug.

This is a pure pharmacological explanation.

Lizzy

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Salmon Egg - 25 May 2007 23:00 GMT

On 5/25/07 11:12 AM, in article
1180116763.026614.233600@k79g2000hse.googlegroups.com,

>> On 5/20/07 6:24 AM, in article 8f6dndfr2eaf0c3bnZ2dnUVZ_gydn...@comcast.com,
>>
[quoted text clipped - 29 lines]
>
> Lizzy

If I interpret this correctly using 5¢ as opposed to $1 words, you are
saying that:

1. Metoprolol is fat soluble so that fat in foods allows increased
absorption.

2. Metoprolol gets metabolized in the liver.

3. The rates for these processes can vary greatly from one person to the
next.

Am I interpreting your post correctly?

Do all beta blockers have these properties?

Bill
-- Fermez le Bush--less than two years to go.

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marindi.irmelize@gmail.com - 26 May 2007 13:25 GMT

> On 5/25/07 11:12 AM, in article
> 1180116763.026614.233...@k79g2000hse.googlegroups.com,
[quoted text clipped - 51 lines]
> Bill
> -- Fermez le Bush--less than two years to go.

Bill,

Yes, you are 100% correct.

There are slight differences between beta-blockers, but they are
modest and sometimes hardly worth mentioning.
The efficacy of beta-blockers differ between patients, so it is likely
that the one prescribed is often the best one for you.

The only difference that is worth mentioning is that some beta-
blockers are better suited to patients with type 1 diabetes,
chronic obstructive pulmonary disease and chronic smokers.

Lizzy

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