some kinetics

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Greg Hansen - 07 Apr 2007 02:34 GMT

Does exercise increase the metabolism of a drug? I thought it might
because it raises the heart rate and moves the blood through the liver
faster.

Does exercise sober you up? They say it doesn't. But they also say
that alcohol is lost in your breath. And it's soluble in water, so I
have to think it comes out in your sweat.

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Gregory Poon - 08 Apr 2007 22:22 GMT

> Does exercise increase the metabolism of a drug? I thought it might
> because it raises the heart rate and moves the blood through the liver
> faster.

It should only be the case if metabolism is perfusion-limited (i.e., not
limited by the intrinsic rate of the metabolizing enzyme), which will
obviously depend on what drug you're talking about. Even then, I doubt
it would make a significant difference, because metabolism typically
occurs intracellularly, and exchange into interstitial spaces and across
the plasma membrane would likely not change very much due to a change in
flow in the vascular space.

> Does exercise sober you up? They say it doesn't. But they also say
> that alcohol is lost in your breath. And it's soluble in water, so I
> have to think it comes out in your sweat.

My guess would be no, since ethanol is primarily cleared by metabolism.

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