Should Odansetron (Zofran) IV liquid be given orally?

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Leo Freeman - 07 Feb 2007 00:08 GMT

My question is : Can odansetron (zofran) IV liquid be given orally?
If a patient has been prescribed odansetron 8mg orally, and the
tablets are not available, can the intravenous liquid be administered
orally instead? Also, if the patient receives an oral dose in the
morning, and an IV dose later on in the evening, is there any chance
of some sort of doubling-up effect as the slowly absorbed morning oral
dose catches up with the rapidly absorbed IV dose?

I'm asking this on behalf of a patient who was worried about this
issue.
Thank you,
Leo

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John Smith ® - 07 Feb 2007 15:53 GMT

> My question is : Can odansetron (zofran) IV liquid be given orally?
> If a patient has been prescribed odansetron 8mg orally, and the
[quoted text clipped - 8 lines]
> Thank you,
> Leo

I would think you could use the injection orally. The tablet and injection
are both the HCl salt. The ODTs are the base, so there may be some changes
in absorption. We give the IV up to every 4 hours, so if you are only
taking it morning and evening you shouldn't have any problems with taking
too much. When I was getting chemo they would push in 4 to 8 mg IV before
they pushed the chemo, then told me to take the ODT tabs every 4 hours as I
needed them. I never had any trouble with too much zofran - but the chemo
really sucked in any amount.

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Ruben Safir - 11 Feb 2007 06:51 GMT

> My question is : Can odansetron (zofran) IV liquid be given orally?

Yes - but consider the costs.

Ruben

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