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Medical Forum / General / Pharmacy / February 2007Problem with one generic and not another?
I have been taking 1.5 mg of Clonazapam (Klonopin) for about a year. I always get it from the same pharmacy and it always works ok. Recently, I started becoming very anxious and uncomfortable - more trouble sleeping, etc. I suddenly realized that this coincided with a change in the maker of the generic I received from the pharmacy. I verified this with the pharmacist who says that they "are the same". But my body doesn't seem to think they are "the same". How often does this happen and what might account for it? TIA Louise On 1/13/07 12:27 PM, in article 50stklF1hb0ntU1@mid.individual.net, "louise" > I have been taking 1.5 mg of Clonazapam (Klonopin) for about > a year. I always get it from the same pharmacy and it [quoted text clipped - 12 lines] > > Louise Maybe you have changed. Have you gone back to the old version? Bill -- Fermez le Bush > On 1/13/07 12:27 PM, in article 50stklF1hb0ntU1@mid.individual.net, "louise" > [quoted text clipped - 19 lines] > Bill > -- Fermez le Bush I can't get the old version - the pharmacy says this present generic is the one they are now getting from their warehouse and they don't have any of the other one. Louise > On 1/13/07 12:27 PM, in article 50stklF1hb0ntU1@mid.individual.net, > "louise" [quoted text clipped - 20 lines] > Bill > -- Fermez le Bush The active drug should be exactly the same, but there may be differences in the binders, fillers, etc. and these can change the way the tablets dissolve and thus are absorbed. These variations should be very minor. Remember almost all generics must have the same bioavailability as the original formulation. If you have been taking a benzo for a year you probably have a depencence and it may be that you have a tolarence and need to increase the dose to get the same effect as you once did. Either try another pharmacy (that has the old formulation) or check with the physician that prescribed it.  SignatureThere is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact. --Mark Twain >> On 1/13/07 12:27 PM, in article 50stklF1hb0ntU1@mid.individual.net, >> "louise" [quoted text clipped - 31 lines] > get the same effect as you once did. Either try another pharmacy (that > has the old formulation) or check with the physician that prescribed it. Maybe u can get the new drug analyzed. Maybe it is counterfeit. >>> On 1/13/07 12:27 PM, in article 50stklF1hb0ntU1@mid.individual.net, >>> "louise" [quoted text clipped - 31 lines] >> > Maybe u can get the new drug analyzed. Maybe it is counterfeit. I've been using this pharmacy for years and if the drug were actually "counterfeit", they would have other complaints and I trust they would have told me so. It seems to be something about how my body reacts to the particular binders, fillers etc. I'm now taking the brand and it seems ok. Louise >>>> On 1/13/07 12:27 PM, in article 50stklF1hb0ntU1@mid.individual.net, >>>> "louise" [quoted text clipped - 40 lines] > > Louise If a pharmacy were to get a batch of counterfeit drugs, and it does happen, then the reporting to the pharmacy of a lessenned effect by a small group of patients, and with possibly multiple pharmacists, is not well understood. A famous case with a large batch of counterfeit erythropoeitin was only found after one patient had a severe reaction to the counterfeit product, and not from the multiple patients who did not get the desired increase in red blood cells from the product. > I have been taking 1.5 mg of Clonazapam (Klonopin) for about >> a year. I always get it from the same pharmacy and it [quoted text clipped - 6 lines] >> pharmacist who says that they "are the same". But my body >> doesn't seem to think they are "the same". there is nearly zero chance that the drugs are clinically different. Ruben Signature__________________________ http://www.mrbrklyn.com http://www.nylxs.com - Leadership Development in Free Software So many immigrant groups have swept through our town that Brooklyn, like Atlantis, reaches mythological proportions in the mind of the world - RI Safir 1998 DRM is THEFT - We are the STAKEHOLDERS - RI Safir 2002 http://fairuse.nylxs.com "Yeah - I write Free Software...so SUE ME" "The tremendous problem we face is that we are becoming sharecroppers to our own cultural heritage -- we need the ability to participate in our own society." ------------------------------------------------- "> I'm an engineer. I choose the best tool for the job, politics be damned. You must be a stupid engineer then, because politcs and technology have been attacted at the hip since the 1st dynasty in Ancient Egypt. I guess you missed that one." > I have been taking 1.5 mg of Clonazapam (Klonopin) for about > a year. I always get it from the same pharmacy and it [quoted text clipped - 12 lines] > > Louise Ask your physician if you can increase the clonazapam dose to 2 mg or whatever until it works the same. You may need a slight dosage adjustment. Even each batch of Klonopin is slightly different from the previous one. Drugs have a certain range in which they can vary and still meet the requirements of the FDA. Are you certain that nothing has changed in your life that might make you more anxious? One of my kids takes clonazepam and he says he can tell the difference between the generic supplied from the VA from those obtained at a local pharmacy. I have better results or just the same from taking generic Coumadin (Warfarin) 2 mg. than I did when I was taking the brand name. |
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