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Medical Forum / General / Pharmacy / November 2006

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Spironolactone

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P T - 04 Nov 2006 04:46 GMT
Do they add that minty odor to Sp. tablets, or is that the smell of the
medicine?
Jason Johnson - 04 Nov 2006 07:20 GMT
Do they add that minty odor to Sp. tablets, or is that the smell of the
medicine?

~~~~~~~~~~~~~~~~~~~~~~~~

I don't know about the odors. If you take that medication, make sure that
you have your potassium levels checked periodically. That medication can
raise your potassium levels esp. if you combine it with an ACE inhibitor.
Pumbaa - 05 Nov 2006 15:27 GMT
> Do they add that minty odor to Sp. tablets, or is that the smell of the
> medicine?

I found this information:
"Spironolactone is practically insoluble in water, soluble in alcohol, and
freely soluble in benzene and in chloroform. Inactive ingredients include
calcium sulfate, corn starch, flavor, hydroxypropyl methylcellulose, iron
oxide, magnesium stearate, polyethylene glycol, povidone, and titanium
dioxide."

This is the on-line Britannica definition of a lactone: "any of a class of
cyclic organic esters, usually formed by reaction of a carboxylic acid group
with a hydroxyl group or halogen atom present in the same molecule.
Commercially important lactones include diketene and -propiolactone used in
the synthesis of acetoacetic acid derivatives and b-substituted propionic
acids, respectively; the perfume ingredients pentadecanolide."

Don't organic esters all have odors?  They are used in perfumes.  However
apparently spironolactone is also flavored.  Have you ever tried chewing the
tablet to see if it tastes awful?
Thomas - 30 Nov 2006 16:18 GMT
It's added ... pure spironolactone smells like manure.

Pharmacist

> Do they add that minty odor to Sp. tablets, or is that the smell of the
> medicine?
John Smith ® - 30 Nov 2006 21:55 GMT
> It's added ... pure spironolactone smells like manure.
>
> Pharmacist
>
>> Do they add that minty odor to Sp. tablets, or is that the smell of the
>> medicine?

I always thought it had sort of a skunk/quart amine odor - so I guess that
is somewhat like manure.

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