 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / General / Pharmacy / September 2006Tobramycin inhalation for Cystic Fibrosis
I am looking for information on Tobramycin Sulfate for IV/IM use in inhalation therapy. If I am giving a 320mg dose, which is 8cc's of 40mg/ml 2cc vials, do I need to dilute this further in the nebulizer? Thanks Kevin Can't help much, but isn't there a commercial preparation? Tobinebs or something like that? (Maybe this is what you're talking about) HTH > Can't help much, but isn't there a commercial preparation? Tobinebs or > something like that? (Maybe this is what you're talking about) HTH Yes. Tobi, from Chiron. 300mg/5ml, salinity (1/4 NS) and pH adjusted. Insanely expensive, but the FDA frowns upon compounding of procucts that are commercially available, and Chiron has sued at least one compounding pharmacy in the past. >> Can't help much, but isn't there a commercial preparation? Tobinebs or >> something like that? (Maybe this is what you're talking about) HTH [quoted text clipped - 6 lines] > procucts that are commercially available, and Chiron has sued > at least one compounding pharmacy in the past. Does not a pharmacy license allow a pharmacist to compound medication. If not, why can't the physician just dispense everything? It is my understanding, and correct me if I am wrong, that a pharmacy can compound medications for patients when there is a medical need for such. If there is dye in a commercial product, and a dye free version is not available, the pharmacy can compound a dye free version to serve a medical need, allergy to the dye. Compounding to avoid using an FDA approved product is not a medical need, purely economic, and is frowned upon. I don't know if it is illegal or not. I am waitting for a response from the FDA. I still don't know if I need to dilute this preparation or not or is it is even advisable to give this. 320mg of tobramycin undiluted in a nebulizer 40mg/ml in 2 cc vials which includes preservatives phenol and metabisulfites. The bulk preservative free powder would be better suited but then it has to be diluted to 20mg/ml solution in half normal saline and given by ultrasonic nebulizer. This was shown in clinical trials to have efficacy but not acceptable to take on a regular basis. Took too long and too combersome. 320mg of tobramycin undiluted in a nebulizer 40mg/ml in 2 cc vials which includes preservatives phenol and metabisulfites, is it ok to give diluted or undiluted? Does anyone have an answer. > >> Can't help much, but isn't there a commercial preparation? Tobinebs or > >> something like that? (Maybe this is what you're talking about) HTH [quoted text clipped - 9 lines] > Does not a pharmacy license allow a pharmacist to compound medication. If > not, why can't the physician just dispense everything? Even using the TOBI product it strikes me that the patient won't get nearly the dose prescribed. Most people get mighty tired after inhaling 2-3ml of solution from a traditional nebulizer setup. If the patient is otherwise fit it might happen but I doubt if a healthy adult would need tobramycin. Is this a CF patient? Richard Molitor, R.Ph. http://www.angelfire.com/wa/pharmacist > It is my understanding, and correct me if I am wrong, that a pharmacy > can compound medications for patients when there is a medical need for [quoted text clipped - 30 lines] > > Does not a pharmacy license allow a pharmacist to compound medication. If > > not, why can't the physician just dispense everything? The patient has Bronchiectasis with Chronic Pseudomonas infection to the lung. > Even using the TOBI product it strikes me that the patient won't get nearly > the dose prescribed. Most people get mighty tired after inhaling 2-3ml of [quoted text clipped - 25 lines] > > which includes preservatives phenol and metabisulfites, is it ok to > > give diluted or undiluted? Does anyone have an answer. Check your math !! >I am looking for information on Tobramycin Sulfate for IV/IM use in > inhalation therapy. If I am giving a 320mg dose, which is 8cc's of > 40mg/ml 2cc vials, do I need to dilute this further in the nebulizer? > Thanks Kevin "Apothecon" <apothecon1-news@yahoo.com> wrote in news:69fKg.144$RW2.78 @trndny04: > Check your math !! >>I am looking for information on Tobramycin Sulfate for IV/IM use in >> inhalation therapy. If I am giving a 320mg dose, which is 8cc's of >> 40mg/ml 2cc vials, do I need to dilute this further in the nebulizer? >> Thanks Kevin Last I knew 8 x 40 =320 But here is a link to an article comparing Tobi with injectable tobramycin http://www.uri.edu/pharmacy/humc/TOBIvsInhaledIVTobramycin2.pdf#search=% 22injectable%20tobramycin%20inhalation%22 |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.