> I need help help me with what are the optimal drug therapy/good
> combination and how many agents, for uncontrolled hypertension,
> especially if the patient also has diabetes and is on insulin therapy.
>
> Thanks
You can view the ADA's guidelines here:
http://www.guideline.gov/summary/summary.aspx?doc_id=8621.
In summary, it suggests an ACE inhibitor or ARB first, adding a thiazide
diuretic, then beta-blocker, and/or calcium channel blocker if needed.
Optimal therapy depends upon individual patient response to the meds, as
well as other patient-specific details/comorbidities.