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Medical Forum / General / Pharmacy / July 2006

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Question for pharmacology folks...

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nef5ht2a@yahoo.com - 30 Jul 2006 09:22 GMT
Hi, a friend of mine asked me a question, and honestly I just don't
have time to figure out the answer, despite several internet searches.
The question is "What is the difference between propoxyphene
hydrochloride vs. propoxyphene napsylate, and what, if any, are the
clinical implications of this difference".  I realize it's not a great
drug in general, however I feel I should try to find out the answer, to
try to help this person who suffers from chronic pain likely due to an
autoimmune disorder.

Thanks in advance for any info that can be provided.

Gary
HankG - 30 Jul 2006 15:45 GMT
> Hi, a friend of mine asked me a question, and honestly I just don't
> have time to figure out the answer, despite several internet searches.
[quoted text clipped - 6 lines]
>
> Thanks in advance for any info that can be provided.

Many times products (as different salts) are produced by companies for
'marketing' purposes, e.g., Pfizer/Roerig (Roerig was a subsidiary
ompany)  --  Atarax (antihistamine) as the hydrochloride, Vistaryl
(tranquilizer) as the pamoate.  Same drug.

Other reasons might be for 'getting-around' other company's patents (can't
think of an example at the moment).

An excerpt from a website
(http://www.rxlist.com/cgi/generic3/propoxnap.htm ) states:  Propoxyphene
napsylate differs from propoxyphene hydrochloride in that it allows more
stable liquid dosage forms and tablet formulations. Because of differences
in molecular weight, a dose of 100 mg (176.8 µmol) of propoxyphene napsylate
is required to supply an amount of propoxyphene equivalent to that present
in 65 mg (172.9 µmol) of propoxyphene hydrochloride.

Again the same drug.  Therapeutically, I believe there is no significant
difference.

HankG
GFX - 31 Jul 2006 01:00 GMT
Thank you; that makes sense.  And I agree that there isn't any significant
difference in performance.  The drug almost seems to cause more adverse
effects than clinically desirable effects, from what I've observed over the
years.  Then again, some people think it's the best thing since chocolate
ice cream - go figure.  Anyway, thanks for the info.

Gary

>> Hi, a friend of mine asked me a question, and honestly I just don't
>> have time to figure out the answer, despite several internet searches.
[quoted text clipped - 28 lines]
>
> HankG
 
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