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Medical Forum / General / Pharmacy / October 2003Brand vs Generic
No- But your replies aree misleading. There is a BIG difference bewteen Brand and generic And some generics are better than the Brand. I agree- that the amount of drug in the brand closely matches that in the generic. HOWEVER - the bioavailabilty does not!! A generic can be 80 to 120% of the bio-availabilty of the original trade name product. The excipients can be different. Classic example - Roxane made a generic Lomotil and used sorbitol as excipient. The drug CAUSED diarrhea, because of the excipient. Good pharmacists push the generics to help patients save money. This is nice. But please study the science behind this effort. What is patently worse issue is switching between generics. One drug could be 120% of original whereas the other 80% - big difference. Or move to japan. They only allow 90-110 variability. Please explain what is bioavailablility and what effects it. Thank you, Ken > No- But your replies aree misleading. There is a BIG difference > bewteen Brand and generic [quoted text clipped - 17 lines] > > Or move to japan. They only allow 90-110 variability. bioavailability refers to the amount of the active ingredient which is absorbed into systemic circulation. Some drugs undergo major metabolism by the liver into inactive metabolites which do no good when absorbed--- however some drugs are totally absorbed free of metabolism. 100% bioavailability would mean that the amount of drug which passes into the circulation as active drug is equal to the amount if it were intravenously injected (in which case 100% would pass into the circulation). Hope that helps. Joe -- Mass R.Ph. > Please explain what is bioavailablility and what effects it. > [quoted text clipped - 20 lines] > > > > Or move to japan. They only allow 90-110 variability. finally a good reply--- I totally agree ken!! Joe-- Mass R.Ph. > No- But your replies aree misleading. There is a BIG difference > bewteen Brand and generic [quoted text clipped - 17 lines] > > Or move to japan. They only allow 90-110 variability. > No- But your replies aree misleading. There is a BIG difference > bewteen Brand and generic [quoted text clipped - 17 lines] > > Or move to japan. They only allow 90-110 variability. I don't think that the amount of sorbitol (granulating agent) per tablet would cause diarrhea. HankG > No- But your replies aree misleading. There is a BIG difference > bewteen Brand and generic > And some generics are better than the Brand. The BIg difference isa in the cost...NOT the effectiveness... > I agree- that the amount of drug in the brand closely matches that in > the generic. > HOWEVER - the bioavailabilty does not!! Bull ... ! > A generic can be 80 to 120% of the bio-availabilty of the original > trade name product. The excipients can be different. Check your references... the same standards apply to each and every individual lot of both Brand and generics.. the variances apply to both! > Classic example - Roxane made a generic Lomotil and used sorbitol as > excipient. The drug CAUSED diarrhea, because of the excipient. In Theory it very well may cause this problem...BUT I kind of doubt that there is enough sorbitol present in 100 tablets to even approach the amount needed to cause diarrhea...I honestly have to admit I do not have an answer to this statement other then I have my doubts.. > Good pharmacists push the generics to help patients save money. This > is nice. But please study the science behind this effort. Since when is saving "my" patients" some money rocket science... > What is patently worse issue is switching between generics. One drug > could be 120% of original whereas the other 80% - big difference. Come on...the same variances apply to brands also... lot "a" of the brand can vary this same amount as lot "b" of the brand.... > Or move to japan. They only allow 90-110 variability. Too expensive to live in Japan...too crowded ..and I do not like their under powered cars... This afternoon I received a call from a woman who wanted to know if we carried Keflex brand cephalexin. I told her we did not. Exasperated she asked if I knew of anyone in town who carried it. She had called several stores and no one had it. I told her that I did not know of anyone. It was really too expensive to sit on the shelf and collect dust. She then told me that she didn't like cephalexin because the last time it did not work as good as Keflex. I explained to her that maybe when she took the cephalexin the bacteria were resistant to it. In that case Keflex would not have made a difference. "Oh" she said. I never really thought about that before > This afternoon I received a call from a woman who wanted to know if we > carried Keflex brand cephalexin. I told her we did not. [quoted text clipped - 11 lines] > > "Oh" she said. I never really thought about that before She's probably allergic to genetics. HankG WHATS generic got to do with efficacy? jp rph > WHATS generic got to do with efficacy? > jp rph > > Well, it depends on the particular brand of generic. I guess you've never seen dusty, crumbly tablets, smelly vitamins, or aspirin tablets that reek from acetic acid and are covered with needle-like crystals of salicylic acid. That aside, I can't believe that you've never been fed this line by someone 'demanding' the brand where not specified. HankG oH, i HAVE been fed the line but I choose the generics I dispense. Again, another reason to be in the independent world jp rph > oH, i HAVE been fed the line but I choose the > generics I dispense. Again, another reason > to be in the independent world > jp rph I worked for a lot of 'independents' since the 50's. Most generics (as they weren't referred to in those days) were manufactured or repackaged by local companies. Price was invariably the overriding factor. HankG > The BIg difference isa in the cost...NOT the effectiveness... And your proof is? Look at an ANDA - the form used to qualify a drug as a generic. Look at the FDA website and look at the stipulations for a approved generic. You have no clue what you are saying - you have never read this stuff. Telling patients that generics save money without looking at the differences > Check your references... the same standards apply to each and every > individual lot of both Brand and generics.. the variances apply to both! > > NO - the rules for NDA and ANDA are different. Varience between lots is different that bio-availability - the fraction absorbed. > > Classic example - Roxane made a generic Lomotil and used sorbitol as > > excipient. The drug CAUSED diarrhea, because of the excipient. This was the liquid formulation - not the tablet - Tablets dont contain sorbitol - what pharmacy school did you study in that thinks sorbitol is an excipient used in tablet formulations. I graduated from BCP! We learned about excipients there. Read the USP You guys are more quacks than some of the doc |
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