allergy to opiates?

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adverse_reaction - 22 Jul 2006 19:17 GMT

looking 4 info. had joint replacement surgery monday-now typing 1-hand.
pls 4give no caps and abbrev.

was given 1 darvocet tab 4 pain post-recovery at surgery center. drs
were aware of codeine *allergy*. quickly experienced nausea, rapid
decrease in bp and heart rate, hypothermia, loss of consciousness.
revived, 2nd episode followed. revived again, sent 2 hosp via amb.
experienced no further symptoms, all completely normal since.

this is 2nd time, 1st was vicodin 15 yrs ago. 1 tab, same events, but
in hosp and immed iv flush done. do not know what treatment was, but
going 2 find out... anesthesiologist present insisted darvocet not the
cause. need 2 know what this is 2 avoid recurrence.

bp fell 2 60/40, heart rate fell 2 4 during 2nd occurrence.

amazingly, have had zero pain since, even tho bone removed and tendon
cut and inserted 2 make joint.

any professional ops on this greatly appreciated and further resources
4 info, as well.

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Dr. Wayne Simon - 23 Jul 2006 05:59 GMT

> looking 4 info. had joint replacement surgery monday-now typing 1-hand.
> pls 4give no caps and abbrev.
[quoted text clipped - 17 lines]
> any professional ops on this greatly appreciated and further resources
> 4 info, as well.

I don't know how he can be so sure?

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adverse_reaction - 23 Jul 2006 07:22 GMT

am convinced darvocet was cause but am told opiate toxidrome is
particular 2 addicts.
do u know anything about this? anesth is ignorant, arrogant. no idea
whom 2 ask or where 2 find clinical info.

> > looking 4 info. had joint replacement surgery monday-now typing 1-hand.
> > pls 4give no caps and abbrev.
[quoted text clipped - 19 lines]
>
> I don't know how he can be so sure?

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Dr. Wayne Simon - 24 Jul 2006 05:47 GMT

There is a term called idiosyncratic reactions. That is a reaction that is
very unusual, but happens in rare circumstances to very few people with a
particular medication. I have seen some very very weird drug reactions
over the years, and some recurred when the patient was willing for a
rechallenge. Although rechallenge today for a series reaction, is usually
considered somewhat unethical in most cases.

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adverse_reaction - 25 Jul 2006 20:33 GMT

had i realized that darvocet would behave like vicodin, i'd never have
taken it!

i have a whole long list of things to which i've had peculiar adverse
reactions, not the least of which is the goo they put under the
dressing under my splint/cast. i'm now on splint/cast #4 in a week,
with dry dressing and doing better. valium wires me, dexedrine puts me
to sleep in a few minutes, adhesive tapes and patches burn my skin.
caffiene has no effect at all. i'm afraid now to take or try anything
new. is there some way to find out what causes these idiosyncratic
reactions? how *rare* are they?

> There is a term called idiosyncratic reactions. That is a reaction that is
> very unusual, but happens in rare circumstances to very few people with a
> particular medication. I have seen some very very weird drug reactions
> over the years, and some recurred when the patient was willing for a
> rechallenge. Although rechallenge today for a series reaction, is usually
> considered somewhat unethical in most cases.

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