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Medical Forum / General / Pharmacy / September 20075HTP - amino acid?
I just saw a blurb in a magazine about 5HTP - "an amino acid metabolite". (Brain converts it to seretonin --- and it's supposedly good for other ailments.) Anyone have any thoughts on this? Here is a site I found on Google which pretty well describes it. http://www.5htp.com/ I'm curious and would appreciate any feedback......... Thanks. 5-HTP is indeed converted into serotonin, and will definatly increase the amount of serotonin in your body. The problem is, it won't be limited just to your brain, and serotonin will form through out your body. This can effect several organ systems. Its worth a try for depression, but don't try taking more than the recomended dose. berryremove@ix.netcom.com (berry) wrote in news:3f7627ff.1144406 @news.west.earthlink.net: > I just saw a blurb in a magazine about 5HTP - "an amino acid > metabolite". (Brain converts it to seretonin --- and it's supposedly [quoted text clipped - 5 lines] > > I'm curious and would appreciate any feedback......... Thanks. That's another thing I'm not clear on, the conversion of 5-HTP to serotonin. Is there a specific enzyme that is involved or is it another promiscuase? I read somewhere that the enzyme was a HydroxySynonymousTransferase that catalyzes the interconversion between two identical molecules with different names. Okay, so you're telling us that if we orally ingest 5-HTP (a molecule with a pKa of about 6) it will be absorbed from the gastric environment intact and undergo the renaming process you mentioned. Once the 5-HT has been renamed some will go to the brain and some will go to the "several organ systems" you alluded to (often abbreviated as the 'S.O.S.'). I know that the animus is one of the S.O.S. but what are the others? And too much serotonin in the S.O.S. can cause serotoninism? Or is serotoninism due to high concentrations of serotonin in the brain? Help me out here you guys, this is really confusing and the boards are coming up in March!! -- my first name must appear in the subject line of all email messages sent to this account or they are autodeleted at the server. Thank you. > 5-HTP is indeed converted into serotonin, and will definatly increase the > amount of serotonin in your body. The problem is, it won't be limited [quoted text clipped - 16 lines] > > > > I'm curious and would appreciate any feedback......... Thanks. Yes, the specific enzyme which converts 5-HTP to 5-HT is called a couple of names, but is generally refereed to as aromactic amino acid decarboxylase. When you eat 5-HTP I assume it gets treated rather like when you eat L- DOPA... you loose a lot in the stomch, then you loose a lot in the blood, and then in the end about 1% gets to the brain. What the crap are you talking about... the animus? Places where serotonin will effect you peripherally are primarily vascular smooth muscle, but also the enteric plexus. I'm not sure whether serotonin syndrome is primarily a central, or peripheral problem... I assume its too much 5-HT in both areas. > That's another thing I'm not clear on, the conversion of 5-HTP to > serotonin. Is there a specific enzyme that is involved or is it [quoted text clipped - 39 lines] >> > >> > I'm curious and would appreciate any feedback......... Thanks. Serotonin syndrome is primarily a problem of CNS overserotonization (my word). Obviously, dramatic changes in serotonergic activity in the CNS translates in to widespread changes in the peripheral systems as the brain has great output to the body (i.e. think thermoregulartory system, vagus nerve, etc etc). Taking a supplement that will end up increasing serotonin levels in the body, will, by itself, probably not result in serotonin syndrome, but in combination with a drug, or drugs, that has activity on the serotonergic systems of the central nervous systems, may. > Yes, the specific enzyme which converts 5-HTP to 5-HT is called a couple > of names, but is generally refereed to as aromactic amino acid [quoted text clipped - 54 lines] > >> > > >> > I'm curious and would appreciate any feedback......... Thanks. >What the crap are you talking about... the animus? Places where serotonin >will effect you peripherally are primarily vascular smooth muscle, but >also the enteric plexus. He's pulling our collective legs. By the way, it's die-clo-fen-ac >> I read somewhere that the enzyme was a >> HydroxySynonymousTransferase that catalyzes the interconversion >> between two identical molecules with different names. Brilliant! >> Okay, so you're telling us that if we orally ingest 5-HTP (a molecule >> with a pKa of about 6) it will be absorbed from the gastric [quoted text clipped - 5 lines] >> serotoninism? Or is serotoninism due to high concentrations of >> serotonin in the brain? I've gotta tape this to the door at the lab. hello you are right > That's another thing I'm not clear on, the conversion of 5-HTP to serotonin. > Is there a specific enzyme that is involved or is it another promiscuase? I [quoted text clipped - 37 lines] > > > > > > I'm curious and would appreciate any feedback......... Thanks. >5-HTP is indeed converted into serotonin, and will definatly increase the >amount of serotonin in your body. The problem is, it won't be limited [quoted text clipped - 12 lines] >> >> I'm curious and would appreciate any feedback......... Thanks. I agree with him about 5 htp. You can find more information at http://www.herbmark.com/5-htp.html >5-HTP is indeed converted into serotonin, and will definatly increase the >amount of serotonin in your body. The problem is, it won't be limited [quoted text clipped - 10 lines] >> metabolite". (Brain converts it to seretonin --- and it's supposedly >[quoted text clipped - 5 lines] Yes its right 4 more info visit : http://www.getnutri.com/5-htp.html >> I'm curious and would appreciate any feedback......... Thanks. |
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