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Medical Forum / General / Pharmacy / October 2005Long Term Storage of Tamiflu
Is there some form of Tamiflu that has a longer than one-year storage period? The prescriptions I have gotten for immediate use all have one-year expirations. I am reading various places that there are some Tamiflu boxes that are marked for three to five year expirations. Also, has anyone seen a table that suggests how long you might extend the storage lifetime of Tamiflu by storing near the bottom of its temperature range (59F) instead of the median 77F?  SignatureWill > Is there some form of Tamiflu that has a longer than one-year storage > period? The prescriptions I have gotten for immediate use all have > one-year expirations. I am reading various places that there are some > Tamiflu boxes that are marked for three to five year expirations. > Also, has anyone seen a table that suggests how long you might extend the > storage lifetime of Tamiflu by storing near the bottom of its temperature > range (59F) instead of the median 77F? I would think you can safely refrigerate just about any medication. The shelf life doubles with every 20C decrease in temperature. I have some prescription meds in a small tupperware container in my refrigerator. Andrew Apparently this is not true with Tamiflu. The recommended storage temperature is 77F and the lowest allowed storage is 59F. In a refrigerator you are going to have about 35F which is way outside the recommended range. SignatureWill > I would think you can safely refrigerate just about any medication. > The shelf life doubles with every 20C decrease in temperature. > I have some prescription meds in a small tupperware container in my > refrigerator. > > Andrew Where did you see that? One site I went to states http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a699040.html#storage-conditions What storage conditions are needed for this medicine? Keep this medicine in the container it came in and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. Another site http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/500062.html states: Storage To store this medicine: Keep out of the reach of children. Do not store the capsules in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down. Store the oral suspension at room temperature or in the refrigerator. However, keep the medicine from freezing. Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children >Apparently this is not true with Tamiflu. The recommended storage >temperature is 77F and the lowest allowed storage is 59F. In a >refrigerator you are going to have about 35F which is way outside the >recommended range. On Wed, 19 Oct 2005 00:43:09 +0000, nospam wrote: > Where did you see that? Manufacturer's Package Insert: For the capsules: Store the capsules at 25ºC (77ºF); excursions permitted to 15º to 30ºC (59º to 86ºF). [See USP Controlled Room Temperature] For the reconstitutable powder: Store dry powder at 25ºC (77ºF); excursions permitted to 15º to 30ºC (59º to 86ºF). [See USP Controlled Room Temperature] Store constituted suspension under refrigeration at 2º to 8ºC (36º to 46ºF). Do not freeze. > On Wed, 19 Oct 2005 00:43:09 +0000, nospam wrote: >> Where did you see that? > Manufacturer's Package Insert: > For the capsules: > Store the capsules at 25ºC (77ºF); excursions permitted to 15º to 30ºC > (59º to 86ºF). [See USP Controlled Room Temperature] > For the reconstitutable powder: > Store dry powder at 25ºC (77ºF); excursions permitted to 15º to 30ºC > (59º to 86ºF). [See USP Controlled Room Temperature] Store constituted > suspension under refrigeration at 2º to 8ºC (36º to 46ºF). Do not > freeze. Room temperature is good, below room temperature is better if long shelf life is an importatant consideration. The first dozen random drugs I perused at rxlist.com all called for storage at USP room temperature (25C +5C, -10C). There's nothing magical about this temperature range, nor is Tamiflu more or less suited to this range than any other drug. Higher temperatures result in more rapid degradation and lower temperatures are a storage burden. Andrew If Tamiflu were safe to store below 59F and could last longer between 33F and 59F, why does the manufacturer instruction label specifically exclude that temperature range? What does the temperature that different drugs are stored at have to do with anything? You can't extrapolate that information safely to different classes of drugs, unless it is on the basis of some chemistry or pharmaceutical properties that are common to some class of drugs, and even then you are speculating. SignatureWill > > On Wed, 19 Oct 2005 00:43:09 +0000, nospam wrote: > [quoted text clipped - 21 lines] > > Andrew |
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