http://www.healthsentinel.com/news.php?event=news_print_list_item&id=828

"Study: Anti-depressants can cause internal bleeding", Reuters, May 16,
2005,
Link:
http://www.reuters.com/newsArticle.jhtml;jsessionid=CFOBVSCA3L320CRBAELCFEY?type
=healthNews&storyID=8507568

Some popular anti-depressant drugs can cause internal bleeding similar
to that triggered by aspirin and related painkillers, researchers said
on Monday.

The anti-depressants involved are Prozac-type selective serotonin
re-uptake inhibitors, or SSRIs, the report from the Northwestern
University Medical School said.

A review of the medical records of 549 patients admitted to hospitals
for acute gastrointestinal bleeding found that ongoing use of such
anti-depressants caused a risk of bleeding similar to that caused by
the regular use of non-steroidal anti-inflammatory drugs, or NSAIDs,
such as aspirin, ibuprofen and naproxen.

"While more research needs to be conducted ... physicians must closely
monitor for this serious adverse event, especially in patients who are
taking both SSRIs and NSAIDs," said Michael Jones, a physician who was
the report's chief author.

"This is a potent example of the need for doctors to be particularly
conscious about potential side effects when prescribing multiple
medications for their patients," he added.

The study was released in Chicago during an annual meeting of
gastrointestinal experts. It was sponsored by TAP Pharmaceuticals, a
U.S. joint venture of Japan's Takeda Pharmaceutical Co. Ltd. and Abbott
Laboratories Inc. The company makes Prevacid, a heartburn drug.

Eli Lilly and Co., which makes Prozac, said the possibility of bleeding
was already listed as a potential side effect of the drug and users
were cautioned about it in information provided with the product.
Monday's study named no specific brands.

Gastrointestinal bleeding from NSAIDS has been blamed for 16,000 deaths
a year in the United States, and that problem helped spur the
development of COX-2 drugs, which were designed to be a safer
replacement.

But the COX-2 drugs were found to raise the risk of heart attacks and
strokes. Two -- Pfizer Inc.'s Bextra and Merck & Co.'s Vioxx -- have
been pulled from the market.

The U.S. Food and Drug Administration also asked Pfizer to include a
strong "black box" warning for its COX-2 Celebrex.