Extemporaneous Mefloquine Syrup Preparation

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robbie_c - 28 Dec 2004 23:41 GMT

I have to prepare a suitable dosage form of mefloquine to give 12
doses of 31.25 mg each (one-eighth of a 250 mg tablet) for a
two-year-old child.

I am proposing to crush one and one-half 250 mg tablets and suspend
them in 60 ml of cherry syrup, with instructions to refrigerate the
mixture and to shake well before pouring. This will provide twelve 5
ml doses each containing 31.25 mg of mefloquine.

I have contacted Barr Labs and inquired if they had any stability
studies for extemporaneous preparations of mefloquine. They did not.

Has anyone in this newsgroup had any experience with extemporaneous
preparations of this drug? Do you have any alternative suggestions for
preparation? Thanks.

rob carter

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who - 29 Dec 2004 05:21 GMT

We do them in powder papers. Weigh the 250mg tab to find out how much
powder will contain the correct dose. Grind the tab(s) to a fine
powder. Weigh out each dose and pack each dose in an individual folded
powder paper. Generally the rx's that we see for this are for 8 to 12
week supplies. Patients may not always have access to refrigeration. A
liquid formulation probably won't be stable long enough, with or without
refrigeration anyway. The powder papers don't require any special
measuring (you've already done it for them) or storage temperatures.

You can reach me at mlgarner @ netins . net if you have any
questions.

Lisa, RPh

> I have to prepare a suitable dosage form of mefloquine to give 12
> doses of 31.25 mg each (one-eighth of a 250 mg tablet) for a
[quoted text clipped - 13 lines]
>
> rob carter

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