> What would make more sense to me than the current flap over naproxen and
> other NSAIDS causing heart attack and stroke would be a comparison of risk
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> Bill
> Although I find the data on the cox 2 inhibitors quite believable, I would
like to see a lot more data proving that the nsaids cause this problem too.
Maybe in patients with renal problems, etc. but old time data seems to
suggest a decrease in MI's in patients taking nsaids. Cox II's probably
elevate blood pressure even in healthy patients and thus there is a direct
correlation with elevating BP and MI. Also cox II's may selectively
increase endothelial stickiness without causing platelet anti-sticking
effects, while the NSAID's may cause an increase in endothelial sensitivity,
they probably decrease platelet adhesion.