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Medical Forum / General / Pharmacy / January 2005What liquid can be used to dissolve Oxycontin for Intravenous Use?
What solvent dissolves the pill, oxycontin, into a liquid for safe intravenous use? I have heard many different answers to this question and do not think any of these solvents are safe for intravenous injection. (ie. vinegar, alcohol ect...) I find many oxymorons in your question. First of all if you are going to experiment illegally with this drug which is obviously what is going to happen then there is no safe way to inject this drug. That is why it comes as a tablet so that it can be swallowed whole without crushing, chewing, snorting or injecting which can lead to overdose or death. Oxycontin (oxycodone) comes in tablets, oral liquid and suppositories. So to answer your question, there is no answer since it is a moot point. > What solvent dissolves the pill, oxycontin, into a liquid for safe > intravenous use? I have heard many different answers to this question > and do not think any of these solvents are safe for intravenous > injection. (ie. vinegar, alcohol ect...) Yet people will still try to "suspend" the tablets in something and inject it ... and end up in the ER with endocarditis. Or clogging up something else and get an infarct. Just great. > I find many oxymorons in your question. First of all if you are going to > experiment illegally with this drug which is obviously what is going to [quoted text clipped - 10 lines] > > and do not think any of these solvents are safe for intravenous > > injection. (ie. vinegar, alcohol ect...) The waxy polymer used in OxyContin's and MS Contin's require mixed solvent systems, the best ones being 80-85% mineral spirits and 15-20% toluene. These should be boiled with the crushed up pills. Then an aqueous phase needs to be mixed into the solvent system. For MS Contin's it is best to convert the Morphine Sulphate into Morphine HCl which is more soluble in water. Oxycodone is already the HCl so this is not necessary. After the mixture is allowed to seperate into an organic layer and an aquous layer, the aqueous layer should be drawn off the bottom using a syringe, leaving the organic layer in tact. More water should then be added to the organic layer and the extraction should be repeated. The excess water should then be evaporated or rotovaped until a managable amount is left. The pH should then be adjusted to about 5.5 to 6.0, otherwise the shot will burn. Note that this is not a simple procedure and should only be done with proper lab setup. You do not want to use an open flame or a stove. Also, make sure you remove the outer coating of the pills with water and a Q tip. MobiusDick (SynthesisDick) wrote >...The excess water should then > be evaporated or rotovaped... Hint to the original poster: Start scrounging garage sales - within a few Saturday afternoons you should be able to find a decent used rotovap for ~$10. >...Note that this is not > a simple procedure... Don't know why you'd say that: I understood everything you said. > (SynthesisDick) wrote > >...The excess water should then [quoted text clipped - 9 lines] > Don't know why you'd say that: > I understood everything you said. Note to P T: I want to live in YOUR neighborhood, where used rotovaps are available at discount prices at GARAGE sales! Any used GC-MSs available? LOL! Dr. P. > (SynthesisDick) wrote > >...The excess water should then [quoted text clipped - 9 lines] > Don't know why you'd say that: > I understood everything you said. The solvent isn't the issue, the issue is the particulate matter that is going to be present when you crush this pill up. Make this a habit and you'll end up with nasty abcesses and destroyed veins if not worse. Not that Oxycodone is all that kind to veins either. But if you insist on injecting this, at least run it though a .2 micron filter first to rid most of the particulate and just use normal sterile saline solution. It's still risky, but far less likely to destroy your veins. > What solvent dissolves the pill, oxycontin, into a liquid for safe > intravenous use? I have heard many different answers to this question > and do not think any of these solvents are safe for intravenous > injection. (ie. vinegar, alcohol ect...) If oxycodone hydrochloride were meant for intravenous use then it would be manufactured that way. For many reasons it is not. #1) there are many other IV opiates that are more efficacious when given IV, #2) Oxycodone Hcl as such is pretty damned acidic and if not buffered it is going to be very nasty on the veins and cause damage if not maybe even a clot. If you want to die of a pulmonary embolism, go ahead, not a fun way to die btw. -- Patrick H. Mason M.S. OHST, EMT-I > The solvent isn't the issue, the issue is the particulate matter that is > going to be present when you crush this pill up. Make this a habit and [quoted text clipped - 10 lines] > > and do not think any of these solvents are safe for intravenous > > injection. (ie. vinegar, alcohol ect...) computernewby wrote: > I find many oxymorons in your question. Lead with an insult. That's a good tactic if you have nothing to say. Way to go. > First of all if you are going to > experiment illegally with this drug which is obviously what is going to > happen then there is no safe way to inject this drug. Follow up the insult with a sentence with no subject and no verb. Now your audience is totally confused. I presume that's exactly where you wanted him, right? > That is why it comes > as a tablet so that it can be swallowed whole without crushing, chewing, > snorting or injecting which can lead to overdose or death. Follow the sentence fragment with a run-on sentence. The reader is reeling from the dizziness, totally in awe of your syntactical brilliance. Furthermore, he's waiting in breathless anticipation of the "many oxymorons" you found, not one of which has yet been mentioned. > Oxycontin (oxycodone) comes in tablets, oral liquid and suppositories. Now you switch gears entirely and state the obvious. The reader is now wondering whether you've led him on by mentioning the oxymorons. But at least he's comforted by a sentence which is actually grammatically correct. > So to answer your question, there is no answer since it is a moot point. And here's the coup de grace. You had nothing to say to begin with! What a finish! > If oxycodone hydrochloride were meant for intravenous use then it would > be manufactured that way. For many reasons it is not. #1) there are many > other IV opiates that are more efficacious when given IV... Patrick, perhaps you failed to infer that the original poster is a drug abuser and doesn't have legal access to intravenous narcotics. Not that all drug abusers do not have access to intravenous narcotics. I once knew an IV dilaudid-using pharmacist, who needless to say had no supply problem. The Internet is such an interesting place, not least because it brings together people who would normally have no opportunity to communicate. I don't think someone who is addicted to narcotics is going to let the risk to his own life stop him from using an unsafe preparation. After all, addicts are not in control of their actions by definition. The drug is in charge, not the drug addict. That's why they can't quit without help. Well put! -- Patrick H. Mason M.S. OHST, EMT-I > > If oxycodone hydrochloride were meant for intravenous use then it > would [quoted text clipped - 17 lines] > drug is in charge, not the drug addict. That's why they can't quit > without help. |
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