Does anyone know if the mode of action of this drug IS .. iron binding /
chelation?

Title: Tamoxifen inhibits lipid peroxidation in cardiac microsomes. Comparison
with liver microsomes and potential relevance to the cardiovascular benefits
associated with cancer prevention and treatment by tamoxifen.
Author(s): Wiseman H; Cannon M; Arnstein HR; Halliwell B

Address: Biomedical Sciences Division, King's College London, Strand, U.K.

Source: Biochem Pharmacol 1993 May 5;45(9):1851-5

Abstract: Tamoxifen and 4-hydroxytamoxifen were both good inhibitors of
iron-dependent lipid peroxidation in rat cardiac microsomes. Tamoxifen was also
a good inhibitor of lipid peroxidation in liposomes prepared from the
phospholipid obtained from rat liver microsomes. In a modified rat liver
microsomal system containing a sufficiently low amount of peroxidizable
phospholipid to make it comparable with the rat cardiac microsomal system,
tamoxifen and 4-hydroxytamoxifen were of similar effectiveness as in the
cardiac system. Tamoxifen is known to lower serum cholesterol levels, and the
findings reported here indicate that the drug might also protect heart cell
membranes against peroxidative damage. Potential cardioprotective and
antiatherosclerotic benefits of tamoxifen are discussed in relation to the
drug's use in cancer prevention and treatment

Major Indexes:

Cardiovascular System [drug effects]
Heart [drug effects]
Lipid Peroxidation [drug effects]
Microsomes, Liver [drug effects]
Neoplasms [prevention & control]
Tamoxifen [pharmacology]
Minor Indexes:
Dose-Response Relationship, Drug
Iron [antagonists & inhibitors]
Liposomes
Microsomes, Liver [metabolism]
Microsomes [drug effects]
Phospholipids [metabolism]
Rats
Tamoxifen [analogs & derivatives] [therapeutic use]
Thiobarbituric Acid Reactive Substances [analysis]
Reagent Names:
0 (Liposomes)
0 (Phospholipids)
0 (Thiobarbituric Acid Reactive Substances)
10540-29-1 (Tamoxifen)
68392-35-8 (4-hydroxytamoxifen)
7439-89-6 (Iron)
Language: English
Periodical Type: JOURNAL ARTICLE

Who loves ya.
Tom