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oxidative stress may offer a common explanation
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Prostaglandins Leukot Essent Fatty Acids. 2004 Sep;71(3):181-3.  Related
Articles, Links  

In vivo magnetic resonance spectroscopy in chronic fatigue syndrome.

Chaudhuri A, Behan PO.

Division of Clinical Neurosciences, Institute of Neurological Sciences,
Southern General Hospital, University of Glasgow, 1345 Govan Road, Glasgow G51
4TF, UK.

The pathogenic mechanisms of chronic fatigue syndrome (CFS) are not clearly
known. Fatigue, poor short-term memory and muscle pain are the most disabling
symptoms in CFS. Research data on magnetic resonance spectroscopy (MRS) of
muscles and brain in CFS patients suggest a cellular metabolic abnormality in
some cases. (31)P MRS of skeletal muscles in a subset of patients indicate
early intracellular acidosis in the exercising muscles. (1)H MRS of the
regional brain areas in CFS have shown increased peaks of choline derived from
the cell membrane phospholipids. Cell membrane oxidative stress may offer a
common explanation for the observed MRS changes in the muscles and brain of CFS
patients and this may have important therapeutic implications. As a research
tool, MRS may be used as an objective outcome measure in the intervention
studies. In addition, regional brain (1)H MRS has the potential for wider use
to substantiate a clinical diagnosis of CFS from other disorders of unexplained
chronic fatigue.

PMID: 15253888 [PubMed - in process]

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