Hello:
I'm 43-years old and just started (about three weeks ago) taking
10 mg of Norvasc daily for hypertension. I take it at night along
with 100 mg of Nortriptilyn for depression.
I've been very active in the last few years--I run several times
a week, play a form of "aerobic paintball" on the weekends for
exercise. Up to this point I've been in very good shape.
It seems that after I started taking the Norvasc a few weeks ago
my stamina has gone all to hell. I get winded much more quickly
and my muscles begin aching after just a few minutes of some
activity that before I could have handled with ease. Further,
when I'm merely at rest, it seems that my pulse rate has
increased dramatically, and--this is gonna sound weird--my heart
seems to be working much harder than it used to. I never used to
notice my heart beat when just sitting but now I do. All in all
the net effect is to make me feel about 20 years older than I am.
Question: could this be the result of the Norvasc?
My blood pressure hasn't really responded all that well to the
Norvasc, and so if the symptoms above are a result of that drug,
it ain't worth it. I have an appointment in a few days to discuss
these things with my doctor, but I thought I'd ask here whether
these are typical symptoms or not.
Thanks!
Gregory Poon - 25 Jun 2004 17:42 GMT
Norvasc (amlodipine) reduces blood pressure by dilating peripheral blood
vessels. One result of this is a reflex to increase heart rate to
compensate, which is consistent with your experience. It may be wise to
back off on the dose (say 5 mg per day) for a short period just to
"acclimatize" yourself to the drug. Hypertension should be aggressively
controlled and yes there are plenty of other antihypertensives but they all
have their own set of side effects and amlodipine isn't terrible.

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Gregory M. K. Poon, Ph.D., R.Ph., B.Sc.Phm.
Departments of Pharmaceutical Sciences and Chemical Engineering
University of Toronto
410-19 Russell Street
Toronto, Ontario
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Voice: (416) 978-5291
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> Hello:
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> Thanks!