Respirology. 2004 Mar;9(1):38-42.  Links

The effects of antioxidants on exercise-induced lipid peroxidation in patients
with COPD.

Agacdiken A, Basyigit I, Ozden M, Yildiz F, Ural D, Maral H, Boyaci H, Ilgazli
A, Komsuoglu B.

Department of Cardiology, University Faculty of Medicine, Kocaeli, Turkey.

The effects of antioxidants on exercise-induced lipid peroxidation in patients
with COPD AGACDIKEN A, BASYIGIT I, OZDEN M, YILDIZ F, URAL D, MARAL H, BOYACI
H, ILGAZLI A, KOMSUOGLU B. Respirology 2004; 9: 38-42Objective: The
oxidant-antioxidant balance plays an important role in the pathogenesis of
COPD. The aim of the present study was to evaluate the effects of exercise, as
an oxidative stress factor on the oxidant-antioxidant balance and to
investigate whether short-term antioxidant treatment affects lipid peroxidation
products. Methodology: Twenty-one stable COPD patients and 10 control subjects
were included in the study. Symptom-limited exercise tests were performed by
all subjects. Blood was collected before and 1 h after exercise in control
subjects and before, 1 and 3 h after exercise in COPD patients, for analysis of
malondialdehyde (MDA), reduced glutathione (GSH) and vitamin E (VE) levels. VE
and vitamin C treatments were added to the regular bronchodilator therapy in 10
COPD patients for 1 month. After the treatment period, an exercise test was
performed and blood was collected again for MDA, GSH and VE levels. Results:
Baseline GSH and VE levels were significantly lower in the COPD group when
compared with the control subjects. There was no statistically significant
difference in MDA levels between the two groups. In the COPD group, MDA levels
3 h after exercise were significantly higher than at baseline. In contrast
there were no significant differences in MDA, VE and GSH levels in the control
group after exercise. VE and MDA levels increased significantly after exercise
in COPD patients but there was no difference in GSH levels. Baseline exercise
time was significantly lower in the COPD group than in the controls. In 10 COPD
patients who were given antioxidant therapy, their exercise time increased
significantly and there was no increase in MDA and VE levels after the repeated
exercise test. Conclusions: Antioxidant levels were significantly lower in COPD
patients than in control subjects. In these patients, exercise results in more
significant oxidative stress and lipid peroxidation than in control subjects
and antioxidant therapy may decrease lipid peroxidation following exercise and
improve exercise capacity.

PMID: 14982600 [PubMed - in process]

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