EFAD for TREGs, proper immune tolerance

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Taka - 31 May 2008 09:03 GMT

Read in the following article for yourself:

http://www.pasteur.fr/applications/euroconf/nutrition/3_Strandvik_abstract.pdf

EFAD was as effective as Omega-3 in inducing oral tolerance via active
suppression mechanism. The worst was the Omega-6/Omega-3 combination
in the proper politically correct ratio ! What's puzzling is the
finding that the Omega-6 supercharged diet also induced oral tolerance
via a different mechanism, i.e. anergy.

Taka

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Taka - 31 May 2008 09:46 GMT

And another "sick logic" paper: EFAD decreases delayed
hypersensitivity (reminds me IgG food allergies so common these days)
but high PUFA diet "doesn't have adverse effects" because 50% corn oil
has the same effect as 13% corn oil.

J Nutr. 1981 Nov;111(11):2039-43.

Effects of dietary fatty acids on delayed-type hypersensitivity in
mice.

Dewille JW, Fraker PJ, Romsos DR.

Effects of an essential fatty acid deficient (EFAD) [0% corn oil (CO)]
diet and a diet high in polyunsaturated fatty acids [PUFA (50% CO)] on
one aspect of in vivo T cell function [delayed-type hypersensitivity
(DTH)] were assessed. After a 70-day feeding trial, DTH was reduced by
30% in mice fed the EFAD diet, but the response of mice fed the high
PUFA diet equaled that of control mice fed a diet containing 13% CO.
The time required for the EFAD diet to reduce DTH was 42 days.
Although consumption of the EFAD diet reduced DTH, this reduction was
rapidly reversed, within 7 days, by switching the EFAD mice to the
control diet. These results indicate that :1) consumption of the EFAD
diet reduces one aspect of in vivo T cell function (DTH), but the
effect can be reversed by refeeding the control diet; and 2) a high
PUFA diet does not adversely affect DTH.

PMID: 6975360

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Taka - 31 May 2008 10:23 GMT

Also on the allergy topic Th2/Th1:

DIFFERENT N-6 POLYUNSATURATED FATTY ACID COMPOSITION OF MILK FROM
ALLERGICAND NON-ALLERGIC MOTHERS

C. Beermann, A. Möller, J. Jelinek, G. Boehm, Numico Research,
Friedrichsdorf, Germany

Conclusion: The reduced gamma-linolenic and dihomo-gamma-linolenic
acid content of breast milk from allergic mothers but did not differed
in arachidonic acid content. The correlation of linoleic to gamma-
linolenic (a p=0.0019) Background: Polyunsaturated fatty acids (PUFA)
serve as precursors for prostaglandines and connecting fat metabolism
and immune system. Prostaglandines are responsible for balancing
cytolytic (Th1) and humoral (Th2) immune response. According to the
immune type paradigm Th2 is correlated to allergy. The arachidonic
acid (20:4n6) dependent PGE2 suppress Th1, the dihomo-gamma-linolenic
acid (20:3n6) dependent PGE1 suppress immunoglobuline E mediated
reactions. Neonates are dominated by Th2 during the prenatal phase.
The developing immune competence of infants after delivery might be
influenced by PUFA. Methods: The fatty acid composition of breast milk
obtained at week 1-8 from type I allergic (n=9) and non- allergic
mothers (n=10) was analysed relatively (r) and absolutely (a).
Results: Breast milk of allergic mothers showed less linoleic acid
(18:2n6) (a p=0.0152; r p=0.0582), gamma-linolenic (18:3n-6) (a
p=0.0604; r p=0.0308), and dihomo-gamma-linolenic acid (a p=0.0488)
compared to milk of non-allergic and dihomo-gamma-linolenic acid (a
p=0.0007) indicates a substrate to product dependency. The fat content
from milk of allergic mothers is 21% (although not significant
p=0.152) less and correlates to the gamma-linolenic acid content (a
p=0.0004; r p=0.0082). mothers reflects the linoleic acid availability
depending on the fat content. Whether the fat content is associated to
allergy needs further investigations.

SOURCE: http://www.issfal.org.uk/index.php?option=com_content&task=view&id=81&Itemid=113%20

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