Lipids. 1997 May;32(5):535-41.

Lipid peroxidation during n-3 fatty acid and vitamin E supplementation
in humans.

Allard JP, Kurian R, Aghdassi E, Muggli R, Royall D.
Department of Medicine, University of Toronto, Ontario, Canada.

The purpose of this study was to investigate in healthy humans the
effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)
intake, alone or in combination with dL-alpha-tocopherol acetate
(vitamin E) supplements on lipid peroxidation. Eighty men were
randomly assigned in a double-blind fashion to take daily for 6 wk
either menhaden oil (6.26 g, n-3 fatty acids) or olive oil supplements
with either vitamin E (900 IU) or its placebo. Antioxidant vitamins,
phospholipid composition, malondialdehyde (MDA), and lipid peroxides
were measured in the plasma at baseline and week 6. At the same time,
breath alkane output was measured. Plasma alpha-tocopherol
concentration increased in those receiving vitamin E (P < 0.0001). In
those supplemented with n-3 fatty acids, EPA and DHA increased in
plasma phospholipids (P < 0.0001) and plasma MDA and lipid peroxides
increased (P < 0.001 and P < 0.05, respectively). Breath alkane output
did not change significantly and vitamin E intake did not prevent the
increase in lipid peroxidation during menhaden oil supplementation.
The results demonstrate that supplementing the diet with n-3 fatty
acids resulted in an increase in lipid peroxidation, as measured by
plasma MDA release and lipid peroxide products, which was not
suppressed by vitamin E supplementation.
PMID: 9168460

neither statins will save you - even this Pharma-sponsored study
admires that fish oil creates more peroxides:

Eur J Clin Nutr. 2003 Jun;57(6):793-800.

Increased lipid peroxidation during long-term intervention with high
doses of n-3 fatty acids (PUFAs) following an acute myocardial
infarction.

Grundt H, Nilsen DW, Mansoor MA, Nordøy A.
Department of Clinical Chemistry, Central Hospital in Rogaland, POB
8100, 4068 Stavanger, Norway.

OBJECTIVE: To assess the oxidative burden of a highly concentrated
compound of n-3 PUFAs as compared to corn oil by measuring
thiobarbituric acid-malondialdehyde complex (TBA-MDA) by HPLC. We also
studied the influence on TBA-MDA of statins combined with n-3 PUFAs or
corn oil. DESIGN: A prospective, randomised, double-blind, controlled
study. SETTING: One hospital centre in Stavanger, Norway. SUBJECTS: A
total of 300 subjects with an acute myocardial infarction (MI).
INTERVENTIONS: Gelatine capsules, containing 850-882 mg EPA and DHA as
concentrated ethylesters, or 1 g of corn oil, were ingested in a dose
of two capsules twice a day for at least 1 y. Alpha-tocopherol (4 mg)
was added to all capsules to protect the PUFAs against oxidation.
RESULTS: After 1 y TBA-MDA increased modestly in the n-3 PUFA group
(n=125), as compared to the corn oil group (n=130), P=0.027. Multiple
linear regression analyses of fatty acids in serum total phospholipids
(n=56) on TBA-MDA measured after 12 months intervention, showed no
dependency. Performing best subsets regression, serum phospholipid
concentration of arachidonic acid (20:4 n-6 PUFA) was identified as a
predictor of TBA-MDA at 12 months follow-up, P=0.004.We found no
impact of statins on TBA-MDA. CONCLUSION: TBA-MDA increased modestly
after long-term intervention with n-3 PUFAs compared to corn oil post-
MI, suggesting biological changes induced by n-3 PUFAs, rather than
simply reflecting their concentration differences. The peroxidative
potential of n-3 PUFAs was not modified by statin treatment.
SPONSORSHIP:: Pharmacia A/S and Pronova A/S, Norway.
PMID: 12792664

The only thing which greatly boosts the antioxidant defenses and can
protect you is CR or the low carb regime.

Taka