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Medical Forum / General / Nutrition / December 2007

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If someone tells you to take "EFA" supplements...

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monty1945@lycos.com - 20 Dec 2007 23:39 GMT
...ask that person if he/she has read the following:

[Cancer Research 45, 1997-2001, May 1, 1985]

In an attempt to determine the requirement of essential fatty acid for
dimethylbenz(a)anthracene-induced mammary tumorigenesis, rats were fed
diets containing different levels of linoleate: 0.5, 1.1, 1.7, 2.2,
3.5, 4.4, 8.5, or 11.5%. Each diet contained 20% of fat by weight,
with varying amounts of coconut oil and corn oil added to achieve the
desired levels of linoleate. Mammary tumorigenesis was very sensitive
to linoleate intake and increased proportionately in the range of 0.5
to 4.4% of dietary linoleate. Regression analysis indicated that a
breakpoint occurred at 4.4%, beyond which there was a very poor linear
relationship, suggesting the possibility of a plateau. From the
intersection of the regression lines in both the upper and lower
ranges, the level of linoleate required to elicit the maximal
tumorigenic response was estimated to be around 4%. The differences in
tumor yield could not be correlated with changes in prostaglandin E
concentration in the mammary fat pads of normal animals maintained on
similar diets, suggesting that linoleate may act by some other
mechanism to stimulate mammary tumorigenesis.

http://cancerres.aacrjournals.org/cgi/content/abstract/45/5/1997
Taka - 21 Dec 2007 08:51 GMT
On Dec 21, 8:39 am, monty1...@lycos.com wrote:
> ...ask that person if he/she has read the following:
>
[quoted text clipped - 19 lines]
>
> http://cancerres.aacrjournals.org/cgi/content/abstract/45/5/1997

If that person is a health "expert" he/she would likely reply that the
effect was due to the very low Omega-3/Omega-6 ratio ...  It's hard to
make people realize that reducing the poison is better than beating it
with another poison.  But very nice paper indeed.  It's not only the
effect of dimethylbenz(a)anthracene, I guess if a global nuclear war
started the only winners could be the EFAD people.  Perhaps NASA may
take some interest in this since they are looking at ways to increase
people's resistance to space radiation when sending them to the Mars.

Taka
 
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