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Medical Forum / General / Nutrition / November 2007Wrong form of vitamin D used again resulting in another failure
What are these people thinking? Vitamin D2 is know to much less effective and to have a shorter biological half life and yet they chose to use it instead of vitamin D3. It seems they are seeking to fail!! Anyway this should be another nail in the coffin of the ergocalciferol as an acceptable vitamin form. ============================= Rheumatology (Oxford). 2007 Nov 12; [Epub ahead of print] Effect of annual intramuscular vitamin D on fracture risk in elderly men and women a population-based, randomized, double-blind, placebo-controlled trial. Smith H, Anderson F, Raphael H, Maslin P, Crozier S, Cooper C. Department of Primary Care, Division of Community-based Clinical Sciences, Geriatric Medicine Group and MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. Objectives. Low trauma fractures in older people incur enormous physical, social and economic costs. Previous research indicates that an annual intramuscular injection of vitamin D may reduce fracture rates in this group. This strategy requires validation in a population setting. Methods. Randomized, double-blind, placebo-controlled trial of 300 000 IU intramuscular (i.m.) vitamin D(2) (ergocalciferol) injection or matching placebo every autumn over 3 years. 9440 people (4354 men and 5086 women) aged 75 yrs and over were recruited from general practice registers in Wessex, England. Primary outcome measure was all non-vertebral fracture. Secondary outcomes were hip and wrist fractures, and all falls. Results. 585 subjects had incident non-spine fractures (hip 110, wrist 116, ankle 37). Hazard ratios (HRs) for fracture in the vitamin D group were: 1.09 [95% confidence interval (CI) 0.93-1.28, P = 0.29] for any first fracture, 1.49 (95% CI 1.02-2.18, P = 0.04) for hip and 1.22 (95% CI 0.85-1.76, P = 0.28) for wrist. There was no effect on falls: HR 0.98 (0.93-1.04). No protective effect was observed in any subgroup when the cohort was stratified by sex, age, previous fracture or mobility. Conclusions. An annual i.m. injection of 300 000 IU vitamin D(2) is not effective in preventing non-vertebral fractures among elderly men and women resident in the general population. PMID: 17998225 On Nov 19, 5:05 am, trigonometry1...@gmail.com wrote: SEEMS RATHER A STUDY DESIGNED TO GENERATE NEGATIVE HEADLINES. > Conclusions. > An annual i.m. injection of 300 000 IU vitamin D(2) > is not effective in preventing non-vertebral fractures among > elderly men and women resident in the general population. > > PMID: 17998225 What does it mean probably nothing .An comparable study on food consumption would be .People overfed for 2 weeks then not fed the rest of the year show no health benefit . Tha real guestion is why was this study even done? Thanks Vince > On Nov 19, 5:05 am, trigonometry1...@gmail.com wrote: > [quoted text clipped - 11 lines] > of the year show no health benefit . Tha real guestion is why was this > study even done? Probably because there is previous study showing that a high dose oral supplementation of vitamin D three times a year was very effective in reducing facture rate. I agree with the original poster's interpretation. The main problem was the form of vitamin D, not vitamin D itself.  SignatureJuhana > On Nov 19, 5:05 am, trigonometry1...@gmail.com wrote: > > An annual i.m. injection of 300 000 IU vitamin D(2) > > is not effective in preventing non-vertebral fractures among > > elderly men and women resident in the general population. > What does it mean probably nothing .An comparable study on food > consumption would be .People overfed for 2 weeks then not fed the rest > of the year show no health benefit . Tha real guestion is why was this > study even done? Vitamin D has a long half-life in the body, so if vitamin D can be injected when flu shots are administered, the subjects can be assured of having adequate vitamin D levels. The test might have been done without supplemental calcium to test the efficacy of vitamin D alone. And, the experiment might have been done before there were doubts about the efficacy of vitamin D2 versus vitamin D3. Since oral vitamin D3 has been shown to reduce bone fractures at doses equivalent to 800 IU, further experiments need to be done to optimize the dose with respect to other nutrients such as calcium, vitamin K, and protein. -- Ron > > On Nov 19, 5:05 am, trigonometry1...@gmail.com wrote: > > > An annual i.m. injection of 300 000 IU vitamin D(2) [quoted text clipped - 8 lines] > injected when flu shots are administered, the subjects can be assured > of having adequate vitamin D levels. Vitamin D2 has a relatively short half-life compared to vitamin D3 which is and has been the primary form in humans since the beginning. As I dimly recall a bolus dose of 40 000 IU of vitamin D2 resulted in the serum level of 25 OH vitamin D being lower than the time prior to the bolus dose at the end of just two weeks!! Apparently this form of D in bolus dosing regimen increases the metabolism of the vitamin. Better results come with the use of vitamin D3 according to serum levels even with bolus dosing regimens. > The test might have been done without supplemental calcium to test the > efficacy of vitamin D alone. And, the experiment might have been done > before there were doubts about the efficacy of vitamin D2 versus > vitamin D3. There have been doubts about D2 for decades. You clearly have a more charitable spirit than I do. Some have an emotional investment in D2 in that is what they've used for "large doses" for decades. > Since oral vitamin D3 has been shown to reduce bone fractures at doses > equivalent to 800 IU, further experiments need to be done to optimize > the dose with respect to other nutrients such as calcium, vitamin K, > and protein. Yes, I agree. 800 IU is a minimal dose and the other factors you mention are important. And Vitamin K is another vitamin in which the levels are low over the bulk of the population. > -- > Ron On Nov 19, 3:05 am, trigonometry1...@gmail.com wrote: > What are these people thinking? Vitamin D2 is know to much less > effective and to have a shorter biological half life and yet > they chose to use it instead of vitamin D3. It seems > they are seeking to fail!! T, I believe that your comments at the beginning, "they are seeking to fail," is correct. Someday soon, someone is going to uncover evidence that large pharmaceutical companies are out there planning some of this negative PR about supplements, including trying to counter all the positives about Vitamin D in the press. Call me a conspiracy theorist, but it just happens all too often . . . Dave |
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