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Medical Forum / General / Nutrition / September 2007suppression of acid may facilitate the colonization of small intestine result in malabsorption
Best Pract Res Clin Gastroenterol. 2001 Jun;15(3):511-21. Occurrence and significance of gastric colonization during acid- inhibitory therapy. Williams C. Royal Alexandra Hospital, Paisley, PA2 9PN, Scotland, UK. There are now a wide variety of drugs available that are able profoundly to reduce the production of gastric acid. These drugs are currently widely prescribed for the treatment of peptic ulceration and gastro- oesophageal reflux disease. One of the main functions of gastric acid is to kill ingested bacteria. Colonization of the gastric lumen occurs in patients on anti-secretory medication, the degree of bacterial overgrowth depending upon the degree of elevation of the pH. There have been concerns that these bacteria may produce carcinogenic nitrosamines and increase the risk of gastric cancer, but there is at present no definitive evidence in support of this. A profound suppression of gastric acid may also facilitate the colonization of the upper small intestine, leading to deconjugation of the bile salts and malabsorption. There is some evidence that profound gastric acid suppression may decrease the number of ingested pathogens required to produce enteric disease. This chapter discusses these potential bacterial complications of therapeutic acid suppression and the evidence for them. PMID: 11403543 Yes, I learned this lesson the "hard way." From what I've seen, there are quite a few people who are deficient in stomach acid, and yet you probably won't find any doctor in the USA who even suggests stomach acid supplements to his/her patients. In fact, when I told a gastroenterologist about Betaine HCl, he had no idea what it was. On Sep 14, 1:40 am, monty1...@lycos.com wrote: > Yes, I learned this lesson the "hard way." From what I've seen, there > are quite a few people who are deficient in stomach acid, and yet you > probably won't find any doctor in the USA who even suggests stomach > acid supplements to his/her patients. In fact, when I told a > gastroenterologist about Betaine HCl, he had no idea what it was. What about probiotics to colonize good bacteria. Do you think that might work as well as pills of HCL? Dolores > On Sep 14, 1:40 am, monty1...@lycos.com wrote: > [quoted text clipped - 7 lines] > might work as well as pills of HCL? > Dolores Logically probiotics should help with a gut flora problem not reflux. In really old circa 1965 Merck manual the Docs were advised to use limburger cheese to reinoculate people with healthy flora after heavy rounds of antibiotics. If one taking an acid suppressor med, the probiotics would logically need to be a steady habit and even then such a situation would be less than ideal. The only thing I've use is live culture yogurt but I have nothing against the idea. Understand I don't think they help the reflux much but they would make one healthier, IMO. In short, betaine HCl does one thing and probiotics do another so the answer is No. On Sep 13, 10:40 pm, monty1...@lycos.com wrote: > Yes, I learned this lesson the "hard way." From what I've seen, there > are quite a few people who are deficient in stomach acid, and yet you > probably won't find any doctor in the USA who even suggests stomach > acid supplements to his/her patients. In fact, when I told a > gastroenterologist about Betaine HCl, he had no idea what it was. While there are Doctors that recommend it, they are few and far between. And they are exiles on the edge of medicine though sometimes what is in my opinion one of the leading edges. And I completely agree about the so-called specialists as too often they blinders on even in what should be their field of expertise. Just do a bit of lurking in the Yahoo hypogonadal group, some of those guys have a better understanding of the in and out in that range of dysfunctions and its tx than do the most of the endos. On Sep 13, 8:59 pm, trigonometry1...@gmail.com wrote: > Best Pract Res Clin Gastroenterol. 2001 Jun;15(3):511-21. > [quoted text clipped - 36 lines] > > PMID: 11403543 Last year I was on PPI's for months, and I went to mexico. My DH got violently ill while we were there. We ate the same food, shared the same bathroom, etc. I did NOT get ill. Actually this was the first time I've been to mexico and haven't gotten violently ill. Go figure. However, while on the PPI's I did gain 25 lbs - without changing my diet. I don't know if you've seen the recent research about how bacteria in the gut can influence metabolism. I have to wonder if the PPI's somehow wiped out the speedy-metabolism bacteria and made room for a colony of sluggish-metabolism bacteria. This time around, I've gained no weight. But I'm also eating 1 cup of active culture yogurt every day. I have mixed feelings about whether the yogurt helps with my issues or not: there are times where I get reflux/dyspepsia right after eating the yogurt. But it might not be the yogurt - it might be the banana I eat with it. Bananas sometimes don't sit well with me! As for the malabsorption issue, I had my blood tested for a variety of nutrients and my results were quite stellar, so no worries there. jen It gets easy when you think in terms of restoring natural biochemistry. When you take drugs you disrupt that, and that's not even considering the long-term consequences. "Good bacteria" can exist in the gut with normal stomach acid production, so I suggest trying the stomach acid test because it is cheap and you can do it yourself without knowing much of anything. Of the people I've mentioned this to, most of those who got back to me on it appeared to be deficient to some degree. One person who was thin put on about 20 pounds after a month or so taking the betaine HCl. On Sep 15, 3:05 pm, monty1...@lycos.com wrote: > It gets easy when you think in terms of restoring natural > biochemistry. When you take drugs you disrupt that, and that's not [quoted text clipped - 5 lines] > be deficient to some degree. One person who was thin put on about 20 > pounds after a month or so taking the betaine HCl. what is this somach acid test called? tks in advance? |
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