High B6 dose / erythromelalgia / IV or IM or PO?

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devfendc@hotmail.com - 23 Aug 2007 19:58 GMT

I am researching the ideal dose and administration of Vitamin B6
(indeed, if anyone can advise regards which form of B6 would be best -
this would be most appreciated!).

I am assisting my father-in-law, who is suffering neuropathic pains
(amongst others), in a search for relief from his "burning foot pain".
It is not a classic erythromelalgia, the significant feature being the
burning sensations.

Thanks,

Devlin

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MarionCohen2332@gmail.com - 25 Aug 2007 15:31 GMT

On Aug 24, 4:58 am, devfe...@hotmail.com wrote:

> I am researching the ideal dose and administration of Vitamin B6
> (indeed, if anyone can advise regards which form of B6 would be best -
[quoted text clipped - 8 lines]
>
> Devlin

Hi Devlin,
I am a Registered Nurse in Australia and have never heard of using Vit
B as an aid for "burning foot pain".
I am interested in the route for administration - you said, I.V.,
I.M., or P.O.? What is P.O.?
I would be happy to research your request to help your father in law
if you wish? Let me know, please?
My uncle in law had the same condition, brought about by Parkinson's
Disease.
Regards,
Marion Cohen

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monty1945@lycos.com - 25 Aug 2007 22:23 GMT

Your claim, as the nurse pointed out, did not seem likely, so I
suggested something that is consistent with the molecular-level
mechanisms. It might take a couple of months to see results, but it's
the only thing that appears to be likely to help. Do as you wish.

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ironjustice@aol.com - 27 Aug 2007 07:09 GMT

>> On Aug 23, 11:58 am, devfe...@hotmail.com wrote:

I am researching the ideal dose and administration of Vitamin B6
(indeed, if anyone can advise regards which form of B6 would be best
-
this would be most appreciated!). <<

The Maillard Reaction: Chemistry at the Interface of Nutrition, Aging,
and Disease Volume 1043 published June 2005
Ann. N.Y. Acad. Sci. 1043: 807-816 (2005). doi: 10.1196/annals.
1333.093
Copyright ? 2005 by the New York Academy of Sciences

Pyridoxamine: The Many Virtues of a Maillard Reaction Inhibitor

PAUL A. VOZIYAN AND BILLY G. HUDSON

Division of Nephrology, Department of Medicine, Vanderbilt University
Medical Center, Nashville, Tennessee 37232, USA

Address for correspondence: Paul Voziyan and Billy Hudson, Division of
Nephrology, Vanderbilt University Medical Center, S-3223 MCN, 1161
21st Avenue South, Nashville, TN 37232-2372. Voice: 615-322-2089; fax:
615-343-7156. paul.voziyan@vanderbilt.edu billy.hudson@vanderbilt.edu

Pyridoxamine (PM) is one of three natural forms of vitamin B6. It is a
critical transient intermediate in catalysis of transamination
reactions by vitamin B6-dependent enzymes. The discovery eight years
ago that PM can inhibit the Maillard reaction stimulated new interest
in this B6 vitamer as a prospective pharmacological agent for
treatment of complications of diabetes. PM application in diabetic
nephropathy has now progressed to a phase III clinical trial.
Investigation of the PM mechanism of action demonstrated that PM
inhibits post-Amadori steps of the Maillard reaction by sequestering
catalytic metal ions and blocking oxidative degradation of Amadori
intermediate. PM also has the capacity to scavenge toxic carbonyl
products of sugar and lipid degradation, and to inhibit reactive
oxygen species. These multiple activities position PM as a promising
drug candidate for treatment of multifactorial chronic conditions in
which oxidative reactions and/or carbonyl compounds confer
pathogenicity.

Key Words: pyridoxamine ? advanced glycation end products ? reactive
carbonyl compounds ? reactive oxygen species ? diabetic complications
? kidney stones

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Tom

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