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Medical Forum / General / Nutrition / August 2007

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Alpha Lipoic Acid and Blood Sugar

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Nick Chan - 22 Aug 2007 03:30 GMT
hello, i've been getting very good sleep when taking alpha lipoic
acid. Then I found out that it may cause low blood sugar, which in
excessive level may cause serious health problems. How much ALA is too
much?
Ron Peterson - 22 Aug 2007 16:19 GMT
> hello, i've been getting very good sleep when taking alpha lipoic
> acid. Then I found out that it may cause low blood sugar, which in
> excessive level may cause serious health problems. How much ALA is too
> much?

http://lpi.oregonstate.edu/infocenter/othernuts/la/ says:
"f you choose to take LA supplements, the Linus Pauling Institute
recommends a daily dose of 200-400 mg/day of racemic LA for generally
healthy people."

--
 Ron
trigonometry1972@gmail.com - 23 Aug 2007 05:41 GMT
Are you monitoring your blood sugar? There are rather nice
units available these days that do better and with much less pain
than in the past. Are you on some med for high blood sugar?
The local drug source or big box store will have an assortment
of units. It is cheaper than an appointment with the Doctor.
And is vastly better than worrying about some risk that
may or may not be real for you.

I've been considering doing this myself even though as far as I
know I from labs of several years ago I was in the normal range.
It seems to me most middle aged persons likely would
do well to monitor both blood pressure and blood sugar
levels as abnormality creeps in and maybe preventable
or at least subject to being slowed down.

Since you have lipoic acid in your regimen, I hope you also take
biotin. If you're having problem with blood sugar level i.e.
syndrome X, type 2 diabetes, biotin also has benefits.
Biotin and lipoic acid are said to compete for absorption
out of the GI tract. Given that I am middle aged and
now overweight, I've started taking a larger dose of biotin of
around 9 milligrams per day.

I'd also consider taking potassium salt of r-alpha lipoic acid instead
of the racemic
stuff. I recently placed my order for my first bottle of the improved
version. I tried the bulk racemic powder, it is nasty. I had to put it
in
capsules. Just having a potassium salt form appeals to me as a result
of that experience.
Nick Chan - 23 Aug 2007 07:52 GMT
i think i have the 200mg LA capsule
initially i take em everyday without biotin, then realize it causes
hair loss
and have very good sleep
i have normal sugar level
i take LA for my 'careful' believe in alternative (and also
mainstream) hiv/aids theory because of my seropositivity. currently i
only have 2mg biotin capsule, which i thought was a lot. do u think i
should take more?

now im just taking 100mg LA which also causes extremely good sleep
even if taken with 2mg biotin. the only cause i could think of is LA
causes lowering of sugar in blood. should I be concerned since i have
normal blood sugar ? or is it practically harmless? (my carbo intake
is typical asian, rice,meat,fish,veggies,tea)

On Aug 23, 12:41 pm, trigonometry1...@gmail.com wrote:
> Are you monitoring your blood sugar? There are rather nice
> units available these days that do better and with much less pain
[quoted text clipped - 26 lines]
> capsules. Just having a potassium salt form appeals to me as a result
> of that experience.
trigonometry1972@gmail.com - 24 Aug 2007 08:52 GMT
Well, I believe the HIV virus is the primary cause of AIDs though I
think associated viruses often contacted the same way worsen
the situation.

As the biotin, I think 2 milligrams is pretty good dose. Anyway
vastly better than the 30 micrograms one sees in some
vitamin formulas. A lack of biotin can cause a loss of hair
as I recall. I've seen some work that used more but this
is an abstract I could find without a search and they
used 2 milligrams.

For sleep, a 500 mg GABA supplement will put me out
especially with melatonin.

I am not sure what the ideal dose of biotin in the context
of lipoic acid supplementation. Given the value of biotin
I'd not want to get too little.

=====================================

Diabetes Metab Res Rev. 2007 May 16; [Epub ahead of print]

Chromium picolinate and biotin combination improves glucose metabolism
in
treated, uncontrolled overweight to obese patients with type 2
diabetes.

Albarracin CA, Fuqua BC, Evans JL, Goldfine ID.

Alpha Therapy Center, 4626 Weber Road, Suite 100, Corpus Christi, TX
78411;
361.852.0600 (voice), USA.

BACKGROUND: Chromium and biotin play essential roles in regulating
carbohydrate
metabolism. This randomized, double-blind, placebo-controlled study
evaluated
the efficacy and safety of the combination of chromium picolinate and
biotin on
glycaemic control. METHODS: Four hundred and forty-seven subjects with
poorly
controlled type 2 diabetes (HbA(1c) >/= 7.0%) were enrolled and
received either
chromium picolinate (600 microg Cr(+3)) with biotin (2 mg), or
matching placebo,
for 90 days in combination with stable oral anti-diabetic agents
(OADs). Major
endpoints were reductions in HbA(1c), fasting glucose, and lipids.
Safety and
tolerability were assessed. RESULTS: Change in HbA(1c) was
significantly
different between treatment groups (p = 0.03). HbA(1c) in the chromium
picolinate/biotin group decreased 0.54%. The decrease in HbA(1c) was
most
pronounced in chromium picolinate/biotin subjects whose baseline
HbA(1c) >/=
10%, and highly significant when compared with placebo (-1.76% vs -
0.68%; p =
0.005). Fasting glucose levels were reduced in the entire chromium
picolinate/biotin group versus placebo (-9.8 mg/dL vs 0.7 mg/dL; p =
0.02).
Reductions in fasting glucose were also most marked in those subjects
whose
baseline HbA(1c) >/= 10.0%, and significant when compared to placebo
(-35.8
mg/dL vs. 16.2 mg/dL; p = 0.01). Treatment was well tolerated with no
adverse
effects dissimilar from placebo. CONCLUSIONS: These results suggest
that the
chromium picolinate/biotin combination, administered as an adjuvant to
current
prescription anti-diabetic medication, can improve glycaemic control
in
overweight to obese individuals with type 2 diabetes; especially those
patients
with poor glycaemic control on oral therapy. Copyright (c) 2007 John
Wiley &
Sons, Ltd.

PMID: 17506119

I recall a very obese friend who was on diabetes meds, who
could not get it thru his head that he needed to cut his meds and
monitor
his blood sugar if he was going to take a high potency
vitamin mineral supplement containing high dose biotin and chromium.
He was shocked that his was light headed from apparently too little
sugar, what did he expect or want? The idea is to reduce ones need for
meds
or to get off them. Now he is ever more obese and sickly.
 
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