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Medical Forum / General / Nutrition / December 2006Bioperine vs. Pepper
According to Sabinsa that makes Bioperine: "Bioperine is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent of piperine. Bioperine may be co-administered with various nutrients for both human and animal health." http://www.bioperine.com/what_is_it.htm Piperine is especially useful for enhancing the absorption of curcumin, which it increases 2000%. http://pmid.us/9619120 The question is, why not just use black pepper? Which is cheaper? To answer that we need to know how much piperine is in black pepper... "However, Kindell (1984) did report an average daily consumption of 359 mg of black pepper daily in the United States. Given that the content of piperine in black pepper varies between 5 and 9%, this would suggest a daily consumption of approximately 60 to 110 µmol of piperine." http://pmid.us/full:12130727 "The natural concentration of piperine in black pepper is around 5-9%." http://www.nutricentre.com/questhealthlibrary/herbs/piperine.aspx "Piperine should be present in from 5.5 to 9 per cent. in good black pepper." http://www.henriettesherbal.com/eclectic/usdisp/piper.html "White pepper has a higher content of piperine (C17H19NO3) and consequently has a hotter taste than black pepper. Fresh peppercorns contain approx. 5 - 9% piperine." http://www.tis-gdv.de/tis_e/ware/gewuerze/pfeffer/pfeffer.htm According to Sabinsa: "...if one believes that since Bioperine is sourced out of black pepper, all one need to do is increase the consumption of black pepper. Again you have gone wrong, for the direct intake of black pepper will not help achieve enhanced nutrient absorption. According to clinical reports, having Bioperine® in the "right place at the right time" in the digestive tract with supplemented nutrient results in enhanced absorption. So Bioperine when taken during illness will have the best nutrient absorption. Besides if piperine were to remain captive in the form of raw black pepper, it will take time for its bioavailability enhancing property to be released. Therefore, a purified extract of piperine is necessary to get the increased absorption." http://www.bioperine.com/black_pepper.htm If we say pepper contains 5% piperine, and we want 20mg piperine, then we need 400mg of pepper. Bioperine powder from BAC costs $2.50 for 1 gram ($2.50/gm). Ground black pepper from bulkfoods.com costs $25.44 for 5 pounds (2270 grams). At 5% piperine, that's 113.5 grams of piperine ($0.224/gm). That's about 1/10th the cost of Bioperine. Taking 20mg Bioperine per day would cost $1.50 per month. Taking 20mg piperine as 400mg pepper per day would cost $0.13 per month. If we say pepper contains 7% piperine, then only need 286mg pepper to get 20mg piperine. Taking that per day would cost $0.09 per month. From the web page -- http://alzheimer.neurology.ucla.edu/diet.html If your physician agrees with the addition of curcumin and DHA along with the main treatment program, we think that Alzheimer patients might want to try the combination of curcumin and dha (should be taken together, because curcumin is not absorbed well unless it is dissolved). Lecithin appears to improve absorption because it is an emusifier. +++++++++++++++ What's implied above is that taking curcumin with an oil and an emusifier (lecithin) will increase absorption. >According to Sabinsa that makes Bioperine: >"Bioperine is a standardized extract from the fruit of Piper nigrum L [quoted text clipped - 57 lines] >If we say pepper contains 7% piperine, then only need 286mg pepper to >get 20mg piperine. Taking that per day would cost $0.09 per month. > From the web page -- > http://alzheimer.neurology.ucla.edu/diet.html [quoted text clipped - 9 lines] > What's implied above is that taking curcumin with an oil and an > emusifier (lecithin) will increase absorption. Yes, other fats too, like fish oil. Bromalin is another one that is often mentioned to increase absorption of curcumin. Though, none are likely to increase it 2000% percent as with piperine. There's negative data on piperine too. From the PDR: "On the negative side, piperine has shown some evidence of being mutagenic and potentially carcinogenic under some circumstances. It has reportedly given rise to mutagenic products on reaction with nitrites. This causes concern since nitrites and piperine may be consumed simultaneously. Risk might increase with high-dose piperine supplementation. In another study, piperine appeared to enhance the bioavailability of aflatoxin B1 in rat tissues. And in yet another study, piperine was found to be cytotoxic to cultured brain neurons. Piperine was said to be non-mutagenic, however, in a study examining effects of the substance on the germ cells of Swiss albino mice. In a recent study utilizing albino rats, piperine, given at doses of 5 and 10 mg/kg body weight for 30 days, resulted (at the 10-mg/kg dose level) in significant reduction in the weights of testes and accessory sex organs as well as severe damage to seminiferous tubules. The 5-mg/kg dose resulted in partial degeneration of germ cells. Decreased mating performance, decreased fertility and anti-implantation activity, along with some other adverse reproductive events, were observed in mice given very high doses of piperine." http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/pip_0322.sh tml But, with an average consumption of 359 mg per person in the US every day, and having been consumed for however many hundreds (thousands?) of years, it's toxic and mutagenic potential seems low at reasonable doses. It's odd that Sabinsa warns not to use more than 20mg of piperine per day, when that's around the average dose per person in the country. > >According to Sabinsa that makes Bioperine: > >"Bioperine is a standardized extract from the fruit of Piper nigrum L [quoted text clipped - 57 lines] > >If we say pepper contains 7% piperine, then only need 286mg pepper to > >get 20mg piperine. Taking that per day would cost $0.09 per month. > > From the web page -- > > http://alzheimer.neurology.ucla.edu/diet.html [quoted text clipped - 11 lines] > > Yes, other fats too, like fish oil. Oops, I read your post earlier and then didn't read it again when I replied. Of course DHA is in fish oil. Bob |
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