Yes, I know that patient was not on statins but was struck by some
interesting correlations.

One interesting piece I read was from Pollmacher. He demonstrated that
in a subset of schizophrenics there in neocortical inflammation prior
to the onset of psychosis. Another study I have read indicated a high
level of autoantibodies to hsp60 in the CSF of schizophrenics. This is
interesting because hsp 60 is a "danger signal" to the immune network.
At a stretch, what is of furthere interest here is:

Typical apds work by blocking DRD2 receptors, mainly located in the BG.
According to David Horrobin (excellent revew article on neuroimmune
effects in psychiatric illnesses) DRD2 occupation is the primary driver
of PLA2 synthesis. PLA2 is upstream of arachidonic acid, which has
significant inflammatory potential and if memory serves me well is also
involved in pge2 synthesis. Interestingly Horrobin cites one study
showing how an iv infusion of pge1 can quickly ameliorate depression.
Possibly because of a competitive interplay with pge 2 synthesis.
Interesting in light of the studies indicating that omega 3
supplementation, which promotes pge 1 synthesis, has proved beneficial
in depression and to a lesser extent in schizophrenia. You should dig
around for Andrew Stoll for some interesting work in that regard. He
has a text: The Omega 3 Connection, which summarises his findings.

At a stretch, the hsp 60 *might* be indicative of white matter
pathologies because oligodendrocytes constitutively express relatively
high levels of this "danger signal". I have also seen a study
indicating that rat ogs Toll receptors are constitutively expressed at
the cell surface. Now there is some research suggesting that hsp 60 can
act as "pseudo ligand" for Toll receptors, it seems that when
endocytosed hsp 60 sets of the second messengers involved. This is
partly why I suggested looking at white matter studies in relation to
schizophrenia might be useful.

It is also worth remembering that first apds had significant anti
histamine action ...

I'm not suggesting schizophrenia is the result of a dysfunctional
immune response. Although it is worth remembering that there is a faint
statistical association between sunlight during pregnancy and the
incidence of schizophrenia(you know, that vitamin D - MS thing). And
just week a report released indicated very high rates of coleiac
disease in schizophrenics and "leaky gut syndrome" definitely gets a
systemic inflammatory response on the go, thereby paving the way for
god knows all sorts of potential problems down the track.

My pont is this: in some cases a direct immune involvement could be
implicated but I suspect that mostly the immune abnormalities are
secondary phenomena.

All this is confounded by my view that schizophrenia as currently
diagnosed represents a possible number aetiologies and conditions and
so we are confronted with confusing data.

I do wish the psychiatric community would pay more attention to the
work of Hoffer, Horrobin, and Stoll. Sadly, the community seems wedded
to the "it's all above the neck" type of thinking and seem to forget
that the brain exists in a body. This bias is actually a ghost of
dualism. But don't tell them that, bods get very upset when you accuse
them of that ...

Hope this helps,

John.