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Medical Forum / General / Nutrition / December 2006Fish Oil: Quality and Potency
Hello. I recently purchased a different type of fish oil called "Krill" and noticed a huge difference in the amount of EPA and DHA. Although the amount was significantly less than in other fish oil formulations, they still claimed it to be "high potency". Is it wrong of me to assume that DHA is DHA is DHA and same for EPA? Or is there a difference depending on source? Here are the numbers... Swanson Super EFA: 1 Gelcap: (Recommended serving) 300 MG EPA 200 MG DHA 50 MG Other omega-3 NSI KriaXanthin Antarctic Krill Oil: 2 Gelcaps: (Recommended serving) 50 MG EPA 20 MG DHA 20 MG Omega-6 1.5 MG Astaxanthin Also, how important is the astaxanthin? One more thing: The Krill oil, despite it's low numbers, was significantly more expensive than most other fish oils. Thanks. Sincerly, Something's fish around here! -<[JD]>- "I would never do crack... I would never do a drug named after a part of my own a.s, okay?" - Denis Leary. > Is it wrong of me to assume > that DHA is DHA is DHA and same for EPA? Or is there a difference > depending on source? nope. important is what else is in there besides the EPA, DHA and (not shure in krill oil) DPA :-) i.e. quality of product. > Also, how important is the astaxanthin? astaxanthin is quite important and may well account for the pricetag asit is not exactly cheap. 2-4mg for cardivascular protection is a good idea in my book. Regards Curious  Signature"I don't wanna die, there's no future in it!" -Curly Howard Before you decide to ingest this toxic stuff, I suggest you read: http://groups.msn.com/TheScientificDebateForum-/fishoilquotesyoushouldread.msnw You will find other information there, including some othing things about fish oil, that you may wish you knew long ago. http://groups.msn.com/TheScientificDebateForum- I've talked to several "fish oil victims" lately, so before you become one yourself, at least acquaint yourself with the actual evidence. On Nov 30, 11:17 am, monty1...@lycos.com wrote: > Before you decide to ingest this toxic stuff, I suggest you read: > [quoted text clipped - 7 lines] > I've talked to several "fish oil victims" lately, so before you become > one yourself, at least acquaint yourself with the actual evidence. Nutritional theories never cease to amaze me. I'm sure there are arguments that can be found about the health risks of distilled water. Admittedly, it's interesting, but cutting omega-3's out of your diet based on a few published studies is a bit extreme, don't you think? Oh and I'm sorry about your fish oil victims, but I'm sure there are many people that were saved by the stuff as well. Since there clearly MANY more articles to the contrary of what you've posted, it seems logical to me to go with the vast majority. I was going to post a few references but hell, go to www.pubmed.com and type "fish oil" for the search. You'll see over 500 articles and after skimming the first few pages, I did not find a single negative article. Some of the studies found no benefit for very specific ailments, but no benefit is obviously not going to cause another "fish oil victim" Here are some random quotes I picked up in three minutes on the page, just as you included in your page: 1) source: Curr Opin Gastroenterol. 2007 Jan;23(1):48-54. SUMMARY: The consumption of dietary fish oil may prove to be an effective adjuvant therapy in colon cancer. 2) J Nutr. 2006 Dec;136(12):2965-9.Click here to read These results demonstrate that DHA may exert its antiobesity effect by inhibiting differentiation to adipocytes, inducing apoptosis in postconfluent preadipocytes and promoting lipolysis. 3) Oh and while your sources cite the possibility of developing macular degeneration by taking fish oil, most of the studies I read on PUBMED had similar conculsions to the following - that it was suspected fish oils would be HELPFUL for AMD (age-related macular degen) but more studies are needed: Efficacy of omega-3 fatty acids in preventing age-related macular degeneration: a systematic review. CONCLUSION: There is some clinical evidence for protection of AMD from omega-3 fatty acids. However, the results are not consistent. Hence, our conclusion is that this issue is neither clearly supported nor refuted by the present world literature. This is an intriguing and extremely important question but needs further study first with prospective cohort designs and, if positive, randomized clinical trials. 4) Although, there were articles that concluded that the fish oils were helpful in the treatment of AMD... and notice the periodical is specific to Ophthamology: Arch Ophthalmol. 2006 Jul;124(7):995-1001.Click here to read CONCLUSIONS: This study of twins provides further evidence that cigarette smoking increases risk while fish consumption and omega-3 fatty acid intake reduce risk of AMD. 5) check this one out... maybe your fish friends would have benefited: Am J Clin Nutr. 2006 Jun;83(6 Suppl):1494S-1498S. Our own unpublished observations from the Framingham Heart Study suggest that > or =180 mg/d of dietary DHA (approximately 2.7 fish servings/wk) is associated with an approximately 50% reduction in dementia risk. ...and that only took about five minutes... - Jason snip >Nutritional theories never cease to amaze me. I'm sure there are >arguments that can be found about the health risks of distilled water. There are!! See below. Under the Monty-world view, that means you should NEVER drink water! Monty also thinks HIV doesn't cause AiDS. Monty is an idiot. George M. Carter *** Gardner JW. Death by water intoxication. Mil Med. 2002 May;167(5):432-4. Comment in: Mil Med. 2003 Mar;168(3):iii; author reply iii-iv. Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Rockville, MD 20850, USA. With recent emphasis on increased water intake during exercise for the prevention of dehydration and exertional heat illness, there has been an increase in cases of hyponatremia related to excessive water intake. This article reviews several recent military cases and three deaths that have occurred as a result of overhydration, with resultant hyponatremia and cerebral edema. All of these cases are associated with more than 5 L (usually 10-20 L) of water intake during a period of a few hours. The importance of maintaining adequate hydration in exertional heat illness prevention cannot be overemphasized, but excessive fluid intake may lead to life-threatening hyponatremia. Current guidelines provide safety by limiting fluid intake during times of heavy sweating to 1 to 1.5 L per hour. *** Garigan TP, Ristedt DE. Death from hyponatremia as a result of acute water intoxication in an Army basic trainee. Mil Med. 1999 Mar;164(3):234-8. Winn Army Community Hospital, Fort Stewart, GA 31314, USA. Several reports during the past 15 years have described hyponatremia as a result of excessive water intake by athletes during endurance races. The high rates of fluid consumption have been attributed to the desire of athletes to prevent heat injury. The military has adopted guidelines for programmed drinking to maintain performance and minimize the risk of heat casualties. As military personnel increase their fluid intake, their risk of hyponatremia as a result of water overload increases. A potentially life-threatening complication is acute water intoxication. We report the first known death of an Army basic trainee as a result of acute water intoxication. The misinterpretation of his symptoms as those of dehydration and heat injury led to continued efforts at oral hydration until catastrophic cerebral and pulmonary edema developed. I really like Astaxanthin a lot. I take a daily 4 mg supplement - either Twin Labs or Vitamin Shoppe. It's anti-inflammatory properties make it very good for me. The fact it suppresses Gamma Interferon makes it very appropriate for my Multiple Sclerosis condition. Gamma Interferon related inflammation has been shown to greatly worsen the MS symptoms. It will not CURE the disease but will lessen the symptoms. Of course lowering IL-12, IL-1,NOS enzyme activity and Tnf-a a tad is also a good idea. A little turmeric does that well. Astaxanthin also lowers Tnf-a and NOS. I have gotten great relief from my hand and knee arthritis from these two supplements. jack n dalton Anti-Inflammatory Properties of Astaxanthin White Paper #4 January, 2001 Astaxanthin has been shown to be a potent anti-inflammatory and may be an effective modality for the management of acute and chronic inflammation associated with certain diseases and conditions - useful for exercise-induced muscle damage, arthritis, and peptic ulcer disease as well as eczema and psoriasis. Kurashige, et al., showed that carrageenan-induced inflammation and subsequent edema in a rat paw caused by reactive oxygens was clearly and efficiently inhibited by astaxanthin, but not by Vitamin E.1 When there is injury to tissue in the human body, a series of events at the vascular and cellular levels occurs, known as the inflammatory response.2 These include injury from bacteria or viruses and the associated-secreted toxins, excessive heat or cold, mechanical (such as a cut by glass or a crushing injury), excessive acids or alkalis or irradiation, or exercise-induced muscle damage.3,4 As a result of excretions of free radical-generating enzymes called cytokines5 from the injured cells and surrounding vascular cells, the arterioles (small vessels that connect to the capillaries) constrict for a fleeting moment (ischemia) and then dilate (reperfusion), bringing an increase in the blood flow to the entire injured area. Reperfusion following ischemia generates considerable reactive oxygen species and free radicals, causing significant increased oxidative stress.2,8 White blood cells migrate from the bloodstream and adhere to the vessel walls for a moment. They then pass through the vessel walls to reside in the injured tissue. This movement of the white blood cells through the vessel walls is the hallmark of the inflammatory response known as exudate. The injured cells release histamine and leukotaxine which cause the vessel walls to let proteins through - not a normal occurrence. These proteins take up and hold water in the injured tissue and the accumulation of this fluid at the site of injury is called swelling (edema). This leaking blood plasma also delivers food and oxygen to the damaged tissue and may also dilute or wash away toxins at the site of injury. With the infusion of more oxygen to the damaged tissue, astaxanthin's potent antioxidant properties will protect the injured cells from further oxidative stress.1 The inflammatory response is inextricably tied to the body's immune system. Any of the above-listed situations causing injury to the body also stimulates the immune system. This system is regulated by the T cells of which there are three types: helper, suppressor and cytotoxic (killer). T helper cells are further differentiated into Th1 and Th2. Th1 cells release Interferon-gamma which activates phagocytes (killer cells), who then produce damage to the body's mucosa. Th2 cells stimulate the production of antibodies by the B cells. When there is no invading antigen, the action of the Th1 cells is considered harmful to the body. We know that astaxanthin suppresses the production of Interferon-gamma in the Th1 clone.6 Astaxanthin suppresses the overproduction of Th1 cells and therefore enhances the production of Th2 (antibody-secreting) cells because these cells cross-regulate one another.7 In the study by Jyonouchi et al6, astaxanthin was tested and compared to beta-carotene, canthaxanthin, zeaxanthin, lutein and lycopene. Astaxanthin's anti-inflammatory and immune-regulating activities were the most potent of the carotenoids tested. Because of its anti-inflammatory and immune-regulating properties as well as its powerful antioxidant capabilities, astaxanthin may well have the potential to become the center of dietary supplement treatment strategies against exercise-induced inflammation and subsequent oxidative stress. Bibliography 1. Kurashige, et al., "Inhibition of Oxidative Injury of Biological Membranes by Astaxanthin, Physiological Chemistry and Physics and Medical NMR, 1990: 22(1), pp. 27-38. 2. "Inflammatory Response in Human Disease," Encyclopaedia Britannica Online. 3. Lane, N., "The effects of different models of exercise on indices of oxidative stress and free radical formation," Proceedings of the 1st Annual Post-Graduate Research Day, School of Physical Education, Sport & Leisure, June 15, 1999. 4. Evans, W., Ph.D., "Exercise and Oxidative Stress: Effect of Vitamin E and Aging," Abstract from NIH Workshop: the Role of Dietary Supplements for Physically Active People, June 1996. 5. "The Inflammatory Response: When the Body is First Invaded," http://www.iol.ie/~alank/CROHNS/PRIMER/inflresp.htm. 6. Jyonouchi, H., et al., "Effects of Various Carotenoids on Cloned, Effector-stage T-helper Cell Activity," Nutrition of Cancer, 1996: 26(3) pp. 313-324. 7. "The Path to a New Medicin," www.astacarotene.se/eng/humanforskning.html (human research), July 2000. 8. Tso, Mark O. M., Lam, Tim-Tak, "Method of Retarding and Ameliorating Central Nervous System and Eye Damage, Patent No. 5,527,533. Washington, D.C., U.S. Patent and Trademark Office, June 18, 1996. Home - Contact Us - Site Map (c) 2002 by US Nutraceuticals. All rights reserved. NOS enzyme activity >> Is it wrong of me to assume >> that DHA is DHA is DHA and same for EPA? Or is there a difference [quoted text clipped - 11 lines] > Regards > Curious Don't forget the phospholipids. The astaxanthin is naturally occurring btw..as are the phospholipids. > > Is it wrong of me to assume > > that DHA is DHA is DHA and same for EPA? Or is there a difference [quoted text clipped - 11 lines] > Regards > Curious : Hello. I recently purchased a different type of fish oil called : "Krill" and noticed a huge difference in the amount of EPA and DHA. Krill oil is not fish oil but an oil of its own. It is made of krills which are small shrimp-like crustaceans. SignatureJuhana > : Hello. I recently purchased a different type of fish oil called > : "Krill" and noticed a huge difference in the amount of EPA and DHA. [quoted text clipped - 4 lines] > -- > Juhana the small crustaceans are the food which fish eat and thus produce EPA and DHA--use of krill oil just removes that step in the production line---i do not know if it is enviromentally sound to use Krill oil...anybody else know? >the small crustaceans are the food >which fish eat and thus produce EPA and DHA--use of krill oil just >removes that step in the production line---i do not know if it is >enviromentally sound to use Krill oil...anybody else know? As for overfishing in general, there may be some enviromental concerns also for krill overfishing, see Krill Oil : by Ray Sahelian, M.D. <http://www.raysahelian.com/krilloil.html> "Environmental concerns regarding krill oil Krill is a tiny crustacean that lives in cold bodies of water. It is comparable in EPA and DHA levels to fish but also has some potent antioxidants like astaxanthin. Sounds good right? Well there is one huge problem. They are whale food, and they are a declining species. Reports beginning in the late 90's didn't look good, and they are no better now. In 1997, Earth Observatory noted that as ice cover becomes less prominent, krill suffer. Not only that, but as noted in the journal Nature in November of 2004, licenses to fish for Krill commercially are likely to go bust since in some areas, populations of krill have fallen by 80% in the past 30 years. For a different perspective, see a letter we received by Neptune Krill Oil company. ..." Krill fight for survival as sea ice melts Eart Obesrvatory DAAC stydy: Upper Crust <http://earthobservatory.nasa.gov/Study/UpperCrust/> and Ecological concerns <http://www.lighthouse-foundation.org/index.php?id=185&L=1> SignatureMatti Narkia > Hello. I recently purchased a different type of fish oil called "Krill" > and noticed a huge difference in the amount of EPA and DHA. Although > the amount was significantly less than in other fish oil formulations, > they still claimed it to be "high potency". Is it wrong of me to assume > that DHA is DHA is DHA and same for EPA? Or is there a difference > depending on source? Yes, DHA and EPA don't differ depening on the source. The body converts DHA to EPA, if needed, and there is some conversion of EPA to DHA, there is also conversion of ALA (found in flax, canola oil, and walnuts) to EPA. Since the omega 3 fatty acids are expensive, use molecularly distilled fish oil and consume foods with a high content of ALA (an ounce of walnuts a day is sufficient). SignatureRon > Hello. I recently purchased a different type of fish oil called "Krill" > and noticed a huge difference in the amount of EPA and DHA. Although [quoted text clipped - 33 lines] > "I would never do crack... I would never do a drug named > after a part of my own a.s, okay?" - Denis Leary. According to .. science .. the little snip below means .. by using / supplementing fish oil .. increases .. oxidative stress. Oxidative stress is a bad thing. Did you know that .. ? http://tinyurl.com/yn9l4u <<snip>> Urinary excretion of thiobarbituric acid reactive substances (TBARS) and malondialdehyde, measured as the thiobarbituric-malondialdehyde adduct (TRA-MDA adduct), and the plasma concentration of the adduct were significantly greater after the fish oil supplement <<snip>> Alpha-Tocopherol influences in vivo indices of lipid peroxidation in postmenopausal women given fish oil. Author Wander RC; Du SH; Ketchum SO; Rowe KE Address Department of Nutrition and Food Management, Oregon State University, Corvallis, 97331-5103, USA. Source J Nutr, 126: 3, 1996 Mar, 643-52 Abstract Although diets containing fish have been shown to be therapeutically valuable, the vitamin E requirement when large quantities of (n-3) fatty acids are consumed is not known. Additionally, as estrogens may function as an antioxidant, the requirement may be modified in postmenopausal women using hormone replacement therapy (HRT). Consequently, the purpose of this study was to measure the impact of graduated doses of RRR-alpha-tocopheryl acetate (TA) on in vivo indices of lipid peroxidation in postmenopausal women with and without hormone replacement therapy when given a supplement of fish oil. Forty-eight postmenopausal women, half receiving (+HRT) and half not receiving (-HRT) hormone replacement therapy, participated in a four-period, double-blind crossover trial. Each period lasted 5 wk followed by a 4-wk washout interval. During each period, the subjects consumed a 15-g supplement of fish oil and either 0, 100, 200, or 400 mg TA/d in a balanced, single square dosing order. Plasma levels of (n-3) fatty acids were significantly higher after fish oil supplementation; alpha-tocopherol concentration of plasma was significantly higher at each level of supplementation compared with the level without supplementation. Urinary excretion of thiobarbituric acid reactive substances (TBARS) and malondialdehyde, measured as the thiobarbituric-malondialdehyde adduct (TRA-MDA adduct), and the plasma concentration of the adduct were significantly greater after the fish oil supplement. Although urinary TBARS decreased linearly as the dose of TA increases (P < or = 0.05), urinary and plasma concentrations of TBA-MDA adduct did not. This study suggests that the evaluation of highly unsaturated fatty acids as oxidative stressors requires several measures of assessment. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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