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Medical Forum / General / Nutrition / October 2006

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Cabernet sauvignon reduces the risk of Alzheimer's disease in mice

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Matti Narkia - 05 Oct 2006 00:31 GMT
A new study directed by Mount Sinai School of Medicine has found that
moderate red wine consumption in a form of Cabernet Sauvignon may help
reduce the incidence of Alzheimer's Disease (AD). The study entitled
"Moderate Consumption of Cabernet Sauvignon Attenuates â-amyloid
Neuropathology in a Mouse Model of Alzheimer's Disease" is in press,
and will be published in the November 2006 issue of The FASEB Journal.
The breakthrough study will also be presented at the "Society for
Neuroscience Meeting" held in Atlanta, Georgia, October 14-18, 2006.

More about this study in the news article

Cabernet sauvignon red wine reduces the risk of Alzheimer's disease
<http://www.eurekalert.org/pub_releases/2006-09/tmsh-csr091806.php>

Related earlier studies:

Luo L, Huang YM.
[Effect of resveratrol on the cognitive ability of Alzheimeros mice]
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Aug;31(4):566-9. Chinese.
PMID: 16951520 [PubMed - in process]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=16951520
>

Anekonda TS.
Resveratrol-A boon for treating Alzheimer's disease?
Brain Res Brain Res Rev. 2006 Jun 9; [Epub ahead of print]
PMID: 16766037 [PubMed - as supplied by publisher]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=16766037
>

Marambaud P, Zhao H, Davies P.
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta
peptides.
J Biol Chem. 2005 Nov 11;280(45):37377-82. Epub 2005 Sep 14.
PMID: 16162502 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=16162502
>

Savaskan E, Olivieri G, Meier F, Seifritz E, Wirz-Justice A,
Muller-Spahn F.
Red wine ingredient resveratrol protects from beta-amyloid
neurotoxicity.
Gerontology. 2003 Nov-Dec;49(6):380-3.
PMID: 14624067 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=14624067
>

Russo A, Palumbo M, Aliano C, Lempereur L, Scoto G, Renis M.
Red wine micronutrients as protective agents in Alzheimer-like induced
insult.
Life Sci. 2003 Apr 11;72(21):2369-79.
PMID: 12639702 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=12639702
>

Bastianetto S, Zheng WH, Quirion R.
Neuroprotective abilities of resveratrol and other red wine
constituents against nitric oxide-related toxicity in cultured
hippocampal neurons.
Br J Pharmacol. 2000 Oct;131(4):711-20.
PMID: 11030720 [PubMed - indexed for MEDLIN
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=11030720
>

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Matti Narkia

Matti Narkia - 05 Oct 2006 01:00 GMT
>A new study directed by Mount Sinai School of Medicine has found that
>moderate red wine consumption in a form of Cabernet Sauvignon may help
[quoted text clipped - 9 lines]
>Cabernet sauvignon red wine reduces the risk of Alzheimer's disease
><http://www.eurekalert.org/pub_releases/2006-09/tmsh-csr091806.php>

Chilean Cabernet Sauvignon and other red wines may have an edge over
the similar wines from other countries:

McDonald MS, Hughes M, Burns J, Lean ME, Matthews D, Crozier A.
Survey of the Free and Conjugated Myricetin and Quercetin Content of
Red Wines of Different Geographical Origins.
J Agric Food Chem. 1998 Feb 16;46(2):368-375.
PMID: 10554248 [PubMed - as supplied by publisher]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=10554248
>

   "... High total flavonol levels appear to be associated with
   the use of thick-skinned grape varieties, such as Cabernet
   Sauvignon, with a high skin:volume ratio, which were left to
   ripen fully in sunny conditions before harvest and which were
   extracted efficiently by modern methods of vinification. Some
   Chilean Cabernet Sauvignon wines contained up to 40 mg of total
   flavonols L(-1), which was higher than the levels detected in
   Cabernet Sauvignon from France, California, and Australia. The
   flavonol content of 1989 and 1990 Cabernet Sauvignon from
   Bulgaria was <6 mg L(-1). Chilean Cabernet Sauvignon, Merlot,
   and Pinot Noir all contained consistently higher concentrations
   of flavonols than their counterparts from different
   geographical regions."

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