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Medical Forum / General / Nutrition / October 2006

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Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure

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Matti Narkia - 03 Oct 2006 22:03 GMT
Vitamin D may help in congestive heart failure:

Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P,
Koerfer R.
Vitamin D supplementation improves cytokine profiles in patients with
congestive heart failure: a double-blind, randomized,
placebo-controlled trial.
Am J Clin Nutr. 2006 Apr;83(4):754-9.
PMID: 16600924 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/abstract/83/4/754

   "... Conclusions:Vitamin D3 reduces the inflammatory milieu in CHF
    patients and might serve as a new antiinflammatory agent for the
    future treatment of the disease. Our data provide evidence for
    the involvement of an impaired vitamin D–parathyroid hormone axis
    in the progression of CHF."

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Matti Narkia

monty1945@lycos.com - 03 Oct 2006 22:59 GMT
The "cyokine profile" can also be "improved" by avoiding all major
sources of polyunsaturated fatty acids and oxidized lipids.
Matti Narkia - 05 Oct 2006 09:58 GMT
>The "cyokine profile" can also be "improved" by avoiding all major
>sources of polyunsaturated fatty acids and oxidized lipids.

Not true, see

Mehra MR, Lavie CJ, Ventura HO, Milani RV.
Fish oils produce anti-inflammatory effects and improve body weight in
severe heart failure.
J Heart Lung Transplant. 2006 Jul;25(7):834-8. Epub 2006 May 24.
PMID: 16818127 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=16818127
>

   "... CONCLUSIONS: Fish oils decrease TNF-alpha production in heart
   failure and improve body weight. Fish oil therapy may represent a
   novel therapeutic approach in late-stage heart failure
   characterized by cardiac cachexia."

Lennie TA, Chung ML, Habash DL, Moser DK.
Dietary fat intake and proinflammatory cytokine levels in patients
with heart failure.
J Card Fail. 2005 Oct;11(8):613-8.
PMID: 16230265 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=16230265
>

   "... TNF-alpha levels were elevated in patients with diets
   higher versus lower in saturated (6.9 +/- 5 versus 4.2 +/- 2
   pg/mL) and trans fats (6.8 +/- 4.5 versus 4.5 +/- 2.8 pg/mL).
   Patients consuming diets higher in polyunsaturated fats had
   lower sTNF-R1 (2391 +/- 1010 versus 3373 +/- 2098 pg/mL) and
   sTNF-R2 (3803 +/- 1187 versus 5974 +/- 3275 pg/mL) levels.
   Higher omega-3 intake produced similar results: sTNF-R1 (2323
   +/- 1304 versus 3307 +/- 1973) and sTNF-R2 (4117 +/- 2646
   versus 5409 +/- 2801). Event-free survival was decreased in
   patients with higher TNF-alpha and sTNF-R1 levels. ..."

Witte KK, Clark AL.
Fish oils--adjuvant therapy in chronic heart failure?
Eur J Cardiovasc Prev Rehabil. 2004 Aug;11(4):267-74. Review.
PMID: 15292759 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=15292759
<

   "Despite advances in medical management and device therapy,
   chronic heart failure (CHF) remains a condition of high
   mortality and poor quality of life. Patients with CHF endure
   frequent admissions to hospital, with exacerbations of
   breathlessness or recurrent acute myocardial infarction and
   have a high incidence of sudden death. A high intake of marine
   polyunsaturated fatty acids (PUFAs) is associated with lower
   cardiovascular mortality in the general population, and
   diabetics, and can reduce cardiovascular deaths post-
   infarction. Many of the effects of PUFAs could be of benefit in
   CHF patients. They can improve endothelial function, reduce
   vascular tone, reduce platelet aggregability, improve
   myocardial relaxation, stabilize myocardial cells by prolonging
   the refractory period, and lead to increased appetite and
   weight gain. They also have potentially important immune-
   modulating effects, reducing cytokine production and release
   and altering prostaglandin metabolism. In this review article
   we discuss the potential benefits of PUFA supplementation in
   CHF patients using data from clinical trials and in vitro
   experiments."

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Matti Narkia

Matti Narkia - 05 Oct 2006 11:51 GMT
>Vitamin D may help in congestive heart failure:
>
[quoted text clipped - 12 lines]
>     the involvement of an impaired vitamin D–parathyroid hormone axis
>     in the progression of CHF."

Related references:

Vieth R, Kimball S.
Vitamin D in congestive heart failure.
Am J Clin Nutr. 2006 Apr;83(4):731-2..
PMID: 16600920 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/full/83/4/731>

Zittermann A, Schleithoff SS, Koerfer R.
Vitamin D insufficiency in congestive heart failure: why and what to
do about it?
Heart Fail Rev. 2006 Mar;11(1):25-33.
PMID: 16819575 [PubMed - in process]
<http://www.springerlink.com/content/q33842r675130057/>

Khouzam RN, Dishmon DA, Farah V, Flax SD, Carbone LD, Weber KT.
Secondary hyperparathyroidism in patients with untreated and treated
congestive heart failure.
Am J Med Sci. 2006 Jan;331(1):30-4.
PMID: 16415661 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=16415661
>

Nishio K, Mukae S, Aoki S, Itoh S, Konno N, Ozawa K, Satoh R, Katagiri
T.
Congestive heart failure is associated with the rate of bone loss.
J Intern Med. 2003 Apr;253(4):439-46.
PMID: 12653873 [PubMed - indexed for MEDLINE]
<http://www.springerlink.com/content/q33842r675130057/>

Olgun H, Ceviz N, Ozkan B.
A case of dilated cardiomyopathy due to nutritional vitamin D
deficiency rickets.
Turk J Pediatr. 2003 Apr-Jun;45(2):152-4.
PMID: 12921304 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=12921304
>

Zittermann A, Schleithoff SS, Tenderich G, Berthold HK, Korfer R,
Stehle P.
Low vitamin D status: a contributing factor in the pathogenesis of
congestive heart failure?
J Am Coll Cardiol. 2003 Jan 1;41(1):105-12.
PMID: 12570952 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=12570952
>
<http://tinyurl.com/fmlen> (full text)

Uysal S, Kalayci AG, Baysal K.
Cardiac functions in children with vitamin D deficiency rickets.
Pediatr Cardiol. 1999 Jul-Aug;20(4):283-6.
PMID: 10368454 [PubMed - indexed for MEDLINE]
<http://www.springerlink.com/content/c7gj6yf22a81430m/>

Abdullah M, Bigras JL, McCrindle BW.
Dilated cardiomyopathy as a first sign of nutritional vitamin D
deficiency rickets in infancy.
Can J Cardiol. 1999 Jun;15(6):699-701. Erratum in: Can J Cardiol 1999
Nov;15(11):1304. Mustafa A [corrected to Abdullah M].
PMID: 10375722 [PubMed - indexed for MEDLINE
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=R
etrieve&dopt=abstractplus&list_uids=10375722
>

Shane E, Mancini D, Aaronson K, Silverberg SJ, Seibel MJ, Addesso V,
McMahon DJ.
Bone mass, vitamin D deficiency, and hyperparathyroidism in congestive
heart failure.
Am J Med. 1997 Sep;103(3):197-207.
PMID: 9316552 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=9316552
>

Brunvand L, Haga P, Tangsrud SE, Haug E.
Congestive heart failure caused by vitamin D deficiency?
Acta Paediatr. 1995 Jan;84(1):106-8.
PMID: 7734890 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=7734890
>

Yaseen H, Maragnes P, Gandon-Laloum S, Bensaid P, N'Guyen B, Ricaud D,
Lecacheux C.
[A severe form of vitamin D deficiency with hypocalcemic
cardiomyopathy]
Pediatrie. 1993;48(7-8):547-9. French.
PMID: 8165115 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=8165115
>

Gillor A, Groneck P, Kaiser J, Schmitz-Stolbrink A.
[Congestive heart failure in rickets caused by vitamin D deficiency]
Monatsschr Kinderheilkd. 1989 Feb;137(2):108-10. German.
PMID: 2716737 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=2716737
>

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Matti Narkia

 
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