http://tinyurl.com/f274p

The above is a link to a discussion of various .. natural substances
which seem to show some efficacy in reducing iron induced oxidation.

The studies below speak to phytic acid .. a natural substance .. which
is used by researchers as a comparison FOR .. 'synthetic'  iron
chelators.

Lipids. 2000 Dec;35(12):1411-3. Related Articles, Links

Protective effect of phytic acid hydrolysis products on iron-induced
lipid peroxidation of liposomal membranes.

Miyamoto S, Kuwata G, Imai M, Nagao A, Terao J.

Department of Nutrition, School of Medicine, The University of
Tokushima, Japan.

Beneficial effects of dietary phytic acid (myo-inositol hexaphosphate;
IP6) have often been explained by its strong iron ion-chelating
ability, which possibly suppresses iron ion-induced oxidative damage in

the gastrointestinal tract. Because phytic acid is hydrolyzed during
digestion, this work aimed to know whether its hydrolysis products
(IP2, IP3, IP4, and IP5) could still prevent iron ion-induced lipid
peroxidation. Studies using liposomal membranes demonstrated that
hydrolysis products containing three or more phosphate groups are able
to inhibit iron ion-induced lipid peroxidation although their
effectiveness decreased with dephosphorylation. Similarly, they also
prevented iron ion-induced decomposition of phosphatidylcholine
hydroperoxide. These results demonstrate that intermediate products of
phytic acid hydrolysis still possess iron ion-chelating ability, and
thus they can probably prevent iron ion-induced lipid peroxidation in
biological systems.

PMID: 11202004 [PubMed - indexed for MEDLINE]

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Title: Phytic acid suppresses 1-methyl-4-phenylpyridinium ion-induced
hydroxyl radical generation in rat striatum
Author(s): T. Obata1
Source: Brain Research Volume: 978 Number: 1 Page: 241 -- 244
Publisher: Elsevier Science
Abstract:
The present study examined the antioxidant effect of phytic acid on
iron (II)-enhanced hydroxyl radical (*OH) generation induced by
1-methyl-4-phenylpyridinium ion (MPP+) in the extracellular fluid of
rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's

solution (0.5 nmol/?l/min) was infused through a microdialysis probe to

detect the generation of *OH as reflected by the non-enzymatic
formation of 2,3-dihydroxybenzoic acid (DHBA) in the striatum. Phytic
acid (100 ?M) did not significantly decrease the levels of MPP+-induced

*OH formation trapped as 2,3-DHBA. To confirm the generation of *OH by
the Fenton-type reaction, iron (II) was infused through a microdialysis

probe. Introduction of iron (II) (10 ?M) enhanced MPP+ induced *OH
generation. However, phytic acid significantly suppressed iron
(II)-enhanced *OH formation after MPP+ treatment (n=6, P<0.05). These
results suggest that the antiradical effect of phytic acid occurs by
chelating iron required for the MPP+-enhanced *OH generation via the
Fenton-type reaction.
? 2003 Elsevier Science B.V., Amsterdam. All rights reserved.
Keywords: [neuroscience society topics] Degenerative disease:
Parkinson's; [neuroscience society topics] Disorders of the nervous
system; Phytic acid; Fenton-type reaction; 1-Methyl-4-phenylpyridinium
ion (MPP+); Hydroxyl radical; Parkinson's disease
Affiliations: 1: Department of Pharmacology and Therapeutics, Oita
Medical University, 1-1 Idaigaoka, Hasama, 879-5593, Oita, Japan

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Tom

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