Lecithin / neuroprotective

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doe - 04 Jan 2004 15:49 GMT

Braz J Med Biol Res. 2003 Dec;36(12):1613-20. Epub 2003 Nov 17. Related
Articles, Links

Neuroprotection by flavonoids.

Dajas F, Rivera-Megret F, Blasina F, Arredondo F, Abin-Carriquiry JA, Costa G,
Echeverry C, Lafon L, Heizen H, Ferreira M, Morquio A.

Departamento de Neuroquimica, Instituto de Investigaciones Biol gicas Clemente
Estable, Universidade da Republica.

The high morbidity, high socioeconomic costs and lack of specific treatments
are key factors that define the relevance of brain pathology for human health
and the importance of research on neuronal protective agents. Epidemiological
studies have shown beneficial effects of flavonoids on arteriosclerosis-related
pathology in general and neurodegeneration in particular. Flavonoids can
protect the brain by their ability to modulate intracellular signals promoting
cellular survival. Quercetin and structurally related flavonoids (myricetin,
fisetin, luteolin) showed a marked cytoprotective capacity in in vitro
experimental conditions in models of predominantly apoptotic death such as that
induced by medium concentrations (200 M) of H2O2 added to PC12 cells in
culture. Nevertheless, quercetin did not protect substantia nigra neurons in
vivo from an oxidative insult (6-hydroxydopamine), probably due to difficulties
in crossing the blood-brain barrier. On the other hand, treatment of permanent
focal ischemia with a lecithin/quercetin preparation decreased lesion volume,
showing that preparations that help to cross the blood-brain barrier may be
critical for the expression of the effects of flavonoids on the brain. The
hypothesis is advanced that a group of quercetin-related flavonoids could
become lead molecules for the development of neuroprotective compounds with
multitarget anti-ischemic effects.

PMID: 14666245 [PubMed - in process]

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Alf Christophersen - 04 Jan 2004 22:09 GMT

>cellular survival. Quercetin and structurally related flavonoids (myricetin,
>fisetin, luteolin) showed a marked cytoprotective capacity in in vitro
>experimental conditions in models of predominantly apoptotic death such as that

A study presented lately on a meeting (abstract presentation) by a
group in my institute found significant differences in uptake of
quercetin and the other compounds mentioned here in people eating "5 a
day" compared to those eating very litte vegetables and fruits. So it
is a good idea to eat "5 a day".

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John - 18 Jan 2004 22:19 GMT

> >cellular survival. Quercetin and structurally related flavonoids (myricetin,
> >fisetin, luteolin) showed a marked cytoprotective capacity in in vitro
[quoted text clipped - 5 lines]
> day" compared to those eating very litte vegetables and fruits. So it
> is a good idea to eat "5 a day".

But will quercetin taken orally pass the Blood Brain Barrier?. The
study seems to suggest this is difficult.

Thanks

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Alf Christophersen - 20 Jan 2004 15:37 GMT

>But will quercetin taken orally pass the Blood Brain Barrier?. The
>study seems to suggest this is difficult.

Have not checked out that, but anyway, prooxidants may do harm many
other places than in brain where quercetin may prevent the harm done.

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