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Medical Forum / General / Nutrition / January 2006

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New mega-3 review study shows no anticancer benefit  :-(

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Knack - 26 Jan 2006 04:03 GMT
I'm not a JAMA subscriber. Does the conclusion covers all forms of omega-3,
including alpha-linolenic PUFA? The Associated Press interview of Doyle
(American Cancer Society) reported only her remark about fish oil.

What about Dr. Budwig's protocol? She insisted that the conjugate of
alpha-linolenic PUFA with casein produced great results.

References :

Catherine H. MacLean, MD, PhD; Sydne J. Newberry, PhD; Walter A. Mojica, MD,
MPH; Puja Khanna, MD; Amalia M. Issa, MPH, PhD; Marika J. Suttorp, MS;
Yee-Wee Lim, MD, PhD; Shana B. Traina, MA; Lara Hilton, BA; Rena Garland,
BA; Sally C. Morton, PhD
Effects of Omega-3 Fatty Acids on Cancer Risk; A Systematic Review
JAMA. 2006;295:403-415

http://jama.ama-assn.org/cgi/content/short/295/4/403

Associated Press release
http://news.yahoo.com/s/ap/20060125/ap_on_he_me/diet_fish_cancer_8
montygram - 26 Jan 2006 04:55 GMT
No results for omega 3 supplementation are valid unless the person or
animal is already overloaded with omega 6s to begin with.  Such studies
do not control for the possibility that Mead acid, an omega 9 PUFA that
human cells can make on their own, is optimal.  Such studies either
used a mixed fat control versus a fat free diet, or, as is more often
the case recently, a high omega 6 diet versus a mixture of omega 3s and
6s.  Omega 3s are ineffectual: blood doesn't clot, proper skin barriers
can't form, etc., so when you have a mixture in your body, some have
concluded, there is a "balance" that is optimal.  The problem is that
there are very unstable molecules that do great harm when lipid
peroxidation occurs, which it will unless your diet is very high in
antioxidants.  Nobody knoww what the correct amounts would be, so it is
really a kind of Russian roulette.  Note that even the omega 9 PUFA,
Mead acid, can be dangerous if it were eaten in large amounts in the
diet without enough antioxidants.  The point is to let your body make
it's own PUFA and don't eat more than trace amounts in the diet.  Fats
like coconut oil and butter have all kinds of beneficial effects, with
no problematic qualities.  The studies that show that "saturated fat"
is bad usually use lard, which is indeed not healthy, but it is because
it is about 60% unsaturated, and with no antioxidants, and thus causes
free radical damage and molecular dysfunction (inhibiting enzymes,
turning on the genetic machinery - NF-bK, etc.).
Knack - 26 Jan 2006 05:24 GMT
When alpha-linolenic acid is conjugated with casein, it should be more
stable, less easily oxidized... correct?

Typically when the subject of antioxidants in foods comes up, one may hear
mention of blueberry, raspberry, red grape skins, billberry, brocolli,
strawberry, undutched cocoa, etc.. But coconut has no such well known
reputation. I've searched and haven't found any ORAC ratings for coconut
oil. If coconut oil has such good antioxidant properties, then why hasn't
that been researched and why isn't that commonly known? After all, millions
of people consume it.
MMu - 26 Jan 2006 09:20 GMT
> No results for omega 3 supplementation are valid unless the person or
> animal is already overloaded with omega 6s to begin with.  Such studies
> do not control for the possibility that Mead acid, an omega 9 PUFA that
> human cells can make on their own, is optimal.

Because it has been shown, repeatedly, that at the time mead acid is built
in the body (which only happens in case of w3/w6 deficiency) a lot of very
bad things start to happen.

> Note that even the omega 9 PUFA,
> Mead acid, can be dangerous if it were eaten in large amounts in the
> diet without enough antioxidants.

Tell me a single food that contains large ammounts of mead acid please.

And if there is none: why is that so?
If mead acid is so much better than w3 / w6 fatty acids there should have
been a selection against animals that consume w3 / w6 fatty acids towards
animals that build only their own mead acid during evolution.
This does not seem to be the case.

>The point is to let your body make
> it's own PUFA and don't eat more than trace amounts in the diet.  Fats
[quoted text clipped - 4 lines]
> free radical damage and molecular dysfunction (inhibiting enzymes,
> turning on the genetic machinery - NF-bK, etc.).

(its NF-kB; and the "genetic machinery" is hopefully *always* turned on..
otherwise we would be dead very soon- protein synthesis, cell cycle,
metabolism.. they all depend on the "genetic machinery")

The bad properties of saturated fats have, in contrast to your theory, not
ever been asociated with any kind of free radical damage- but if you have
literature that indicates otherwise please be kind enough to post a
citation.
 
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